Search Results - production

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Generation of mutant mouse alleles that functionally disrupt production of BDNF from its ndividual promoters

This technology relates to a mouse model that improves an existing method of disrupting the production of the BDNF protein in specific parts of the brain. A current avenue of research seeks to examine how gene expression may effect long-lasting changes in the nervous system. Previous work has resulted in a mouse line in which the production of BDNF...

Published: 7/25/2024 | Inventor(s): Keri Martinowich

Keywords(s): ALLELES, AXXXXX, BDNF, DISRUPT, FUNCTIONALLY, Generation, Indiividual, Mouse, MUTANT, NC4XXX, NCXXXX, production, PROMOTERS, That, VEXXXX, WIXXXX, XEXXXX

Category(s): TherapeuticArea > Neurology, Application > Research Materials, Application > Therapeutics

Plasmids Encoding and Producing Anthrax Toxin Proteins

Plasmid pSJ136-EF-A — A plasmid encoding mutant anthrax toxin proteins such as lethal factor (LF) or edema factor (EF). Anthrax toxin and anthrax toxin fusion proteins may be used as therapeutic agents for cancer. Plasmid PSJ115-LFOS — A plasmid expressing anthrax toxin proteins such as lethal factor (LF) or edema factor (EF) which has the original...

Published: 7/25/2024 | Inventor(s): Pradeep Gupta, Yiu Cheung, Haijing Hu, Mahtab Moayeri, Stephen Leppla

Keywords(s): Anthrax, Improved, Listed LPM Soukas as of 4/15/2015, Methods, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, production, proteins, RM, TOXINS, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Viral Like Particles Based Chikungunya Vaccines

Chikungunya virus (CHIKV) is mosquito-borne alphavirus endemic in Africa, India, and Southeast Asia. In 2013 CHIKV infection has also emerged in the Caribbean and a pandemic of CHIKV has re-emerged in the Philippines following Typhoon Haiyan. Currently, there is no vaccine available for the prevention of CHIKV infection and no specific therapy exists...

Published: 7/25/2024 | Inventor(s): Wataru Akahata, Srinivas Rao, Gary Nabel

Keywords(s): Against, ALPHA, ALPHAVIRUS, CAPSID, Chikungunya, CHIKV, DC5BXX, Development, DNA vaccine, E1, E1-E2, E2, Envelope, Generation, Method, MODIFICATION, Modifications, PARTICLES, Patent Category - Biotechnology, PLASMID, PREVENTIVE, production, Protein, proteins, Vaccine, VBXXXX, viral, virus, VIRUS-LIKE, VLPs, VLXXXX, XHXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Diagnostics, ResearchProducts > Research Equipment

Protease Deficient Bacillus anthracis with Improved Recombinant Protein Yield Capabilities

Species of Bacillus, such as Bacillus anthracis, Bacillus cereus, and Bacillus subtilis, are attractive microorganisms for recombinant protein production in view of their fast growth rate, high yield, and ability to secrete produced products directly into the medium. Bacillus anthracis is also attractive in view of its ability to produce anthrax toxin...

Published: 7/25/2024 | Inventor(s): Stephen Leppla, Andrei Pomerantsev

Keywords(s): Anthracis, Anthrax, ATCC, Bacillus, Bacterial, BH460, DB3XXX, DBXXXX, DC4XXX, DC6XXX, DCXXXX, DDXXXX, DEXXXX, DXXXXX, HOST, Improved, production, proteins, toxin, vaccines

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, Application > Therapeutics, Application > Research Materials, TherapeuticArea > Infectious Disease

A Computer Program to Predict Optimal Sites on Protein Sequences for Production of Peptide-Directed Antibodies (NHLBI AbDesigner)

The invention offered for licensing is a computer program called "NHLBI AbDesigner" that allows the user to input a unique identifier for an individual mammalian protein to be analyzed in order to find out what short peptides in its amino sequence would most likely result in a strong immunogenic response when injected into a research animal. The software...

Published: 7/25/2024 | Inventor(s): Mark Knepper

Keywords(s): AbDesigner, ACXXXX, Along, antibodies, AXXXXX, CALLED, computer, INDIVIDUAL, NHLBI, OPTIMAL, Peptide-directed, PREDICTS, Primary, production, Program, proteins, sequence, Sites, That

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

System and Method for Producing Nondiffracting Light Sheets that Improves the Performance of Selective Plane Illumination Microscopy (SPIM)

The technology offered for licensing relates to a system and method of producing nondiffracting beams of light that spatially overlap, but do not interfere with each other when intersecting the detection plane of an optical arrangement. The system includes an illumination source (i.e. ultrafast laser) for transmitting a beam of light through the optical...

Published: 7/25/2024 | Inventor(s): Hari Shroff, Andrew York

Keywords(s): AC3XXX, ACXXXX, AXXXXX, BEAMS, ILLUMINATION, LIGHT, MICROSCOPE, Multiplicity, Nondiffracting, optical, PLANE, production, SELECTIVE, Sheets, SpatiallyOverlapping, Subsequent

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Device and Method for Direct Measurement of Isotopes of Expired Gases: Application in Research of Metabolism and Metabolic Disorders, and in Medical Screening and Diagnostics

The technology offered for licensing and for further development concerns a novel device for intervallic collection of expired gas from subjects and subsequent measurement of the isotopic content of such expired gases. The device is specifically designed for medical research and clinical applications, and in particular in the area of metabolic disorders....

Published: 7/25/2024 | Inventor(s): Randy Chandler, Charles Venditti

Keywords(s): (4)r syndrome, 3-@hydroxyacyl-coa dehydrogenase deficiency, AC3XXX, Acid, Acidemia, isovaleric, ACXXXX, AMINO, AXXXXX, C syndrome, C13CO2, Chamber, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, CO2, Detection, Direct, FATTY, G syndrome, HAD deficiency, HIS deficiency, Histidinemia, Hypertelorism with esophageal abnormality and hypospadias, Isotope, Isovaleric acidemia, Maple syrup urine disease, Mass, MEASURE, Measureirent, MEASUREMENT, metabolic disorder, Method, Methylmalonic acidemia, Mice, N syndrome, Non-alcoholic steatohepatitis (NASH), ORGANIC, OXIDATION, Patent Category - Mech/Elect/Soft, Phenylketonuria, production, QUANTITATION, R(6) syndrome, R(7) syndrome, RATES, RATIO, respiratory, SPECTROMETRY, SUBSTRATES, Syndrome X, Vivo, W syndrome, W syndrome; Syndrome W

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Methods for Expression and Purification of Immunotoxins

The invention concerns immunotoxins and methods of making the immunotoxins. Targeting of the immunotoxins occurs via an antibody that is specific to T cells. This allows the specific ablation of malignant T cells and resting T cells. The transient ablation of resting T cells can "reset" the immune system by accentuating tolerizing responses. As...

Published: 7/25/2024 | Inventor(s): David Neville

Keywords(s): Aplastic anemia, Are, Bivalent, CB6XXX, CBXXXX, COMPLEX, CXXXXX, ESSENTIAL, Graft versus host disease, IB3XXX, IBXXXX, Immunotoxin, IXXXXX, LOW, lymphoma, Media, PASTORIS, PICHIA, production, temperature

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Immunology, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Oncology

Vaccines Comprising Sand Fly Salivary Proteins for Control of Leishmania Infection

This invention relates to the use of several peptides from the salivary glands of various sand fly species for the control of leishmania infection. Many of these peptides were shown to be effective in eliciting potent immune responses in animal models and are excellent candidates for the development of vaccines against the disease. A vaccine comprising...

Published: 7/25/2024 | Inventor(s): Jesus Valenzuela

Keywords(s): Adn, America, ARIASI, Cellular, Chagase, DA2XXX, DAXXXX, DB2XXX, DBXXXX, DC2XXX, DCXXXX, DDXXXX, Dogs, DXXXXX, Efficient, ELICIT, Fly, Identification, IFN-gamma, Immunity, Infantum, KILLING, Latin, LEISHMANIA, LEISHMANIASIS, Leishmaniasis (Leishmania sp.), Listed LPM Stansberry as of 4/15/2015, LJL143, LJM17, Longipalpis, Lutzomyiz, Method, P., Patent Category - Biotechnology, PERNICIOSUS, POLYPEPTIDES, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, production, proteins, RESULTING, Salivary, SAND, That, Vector, Visceral, WIPO Re:search

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease

Production of Adeno-Associated Viruses in Insect Cells

Adeno-associated virus (AAV) is being developed for gene therapy applications. This virus type presents several advantages over alternate vectors for therapeutic gene delivery. AAV is not considered pathogenic and transduces stably dividing and non-dividing cells. AAV also shows good serotype specificity to various cell types for targeted gene delivery. The...

Published: 7/25/2024 | Inventor(s): Robert Kotin

Keywords(s): AAV, AAV1, AAV2, AAV5, Adeno-associated, CB2AXX, CB2XXX, CBXXXX, Cells, CXXXXX, Duke DNA Project, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GENE THERAPY, GXXXXX, insect, production, virus

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

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