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Novel Epitopes of Bacillus anthracis Lethal Factor for Development of Diagnostics and Therapeutics

CDC researchers have characterized epitopes of Bacillus anthracis Lethal Factor (LF), a critical component of the B. anthracis lethal toxin. These epitopes may allow for development of therapeutics for the treatment or prevention of B. anthracis infection. They may also allow screening for B. anthracis LF in a sample and development of a peptide anthrax...

Published: 7/25/2024 | Inventor(s): Dennis Bagarozzi, Anne Boyer, Conrad Quinn, Jason Goldstein

Keywords(s): Activiating, Activity, Anthracis, Anthrax, AnthraxToxins, Bacillus, Biodefense, biosecurity, bioterrorism, Bioterrorist, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DA5XXX, DAXXXX, DB3XXX, DB5XXX, DBXXXX, DC4XXX, DCXXXX, DXXXXX, Epitope, factor, INFECTIOUS, Lethal, MONITOR, MONITORING, Neutralize, Neutralizing, Region, REGULATING, SCREEN, screening, SERODIAGNOSIS, SERODIAGNOSTIC, Serologic, SEROLOGICAL, therapeutic, Therapeutic/Diagnostic, THERAPY, toxin, TOXIN-BINDING, Vaccine, VBXXXX, VETERINARY, Via, VJXXXX, VOXXXX, WAXXXX, WBXXXX, WFXXXX, WJXXXX, WKXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YAXXXX, YBXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, ResearchProducts > Research Equipment, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Antibodies, Application > Diagnostics

Full-Length Infectious cDNA Clones of Tick Borne Flavivirus

The tick-borne encephalitis virus complex of flavivirus family includes tick-borne encephalitis (TBEV), Kyasanur forest disease, Langat, Louping ill, Negishi, Omsk hemorrhagic fever and Povassan viruses. These viruses are endemic throughout most of the Northern Hemisphere and except for Langat, cause human disease of varying severity that can have...

Published: 7/25/2024 | Inventor(s): Robert Chanock (Estate), Alexander Pletnev

Keywords(s): Borne, cDNA, CLONES, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Flavivirus, FULL-LENGTH, Hemorrhagic fever, INFECTIOUS, Omsk hemorrhagic fever, Patent Category - Biotechnology, Q fever, SACGHS DNA Patent Initial Set, TICK, Tick-borne encephalitis, UAXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases

A Full-Length Infectious cDNA Clone of Zika Virus from the 2015 Epidemic in Brazil as a Genetic Platform for Studies of Virus-Host Interactions and Vaccine Development

An arthropod-borne virus, Zika virus (ZIKV), has recently emerged as a major human pathogen. Associated with complications during perinatal development and Guillain-Barré syndrome in adults, ZIKV raises new challenges for understanding the molecular determinants of flavivirus pathogenesis. This underscores the necessity for the development of a reverse...

Published: 7/25/2024 | Inventor(s): Konstantin Tsetsarkin, Alexander Pletnev

Keywords(s): 2015, Brazil, cDNA, CLONE, DAXXXX, DBXXXX, DC5BXX, DC5XXX, DC6XXX, DCXXXX, DD1XXX, DDXXXX, Development, DXXXXX, Epidemic, FULL-LENGTH, Genetic, INFECTIOUS, INTERACTIONS, PLATFORM, STUDIES, Vaccine, virus, Virus-Host, Zika

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Research Materials, Application > Diagnostics

Construction of an Infectious Full-Length cDNA Clone of the Porcine Enteric Calicivirus RNA Genome

Porcine enteric calicivirus (PEC) is a member of the genus Sapovirus in the family Caliciviridae. This virus causes diarrheal illness in pigs, and is presently the only enteric calicivirus that can be grown in cell culture. In addition to its relevance to veterinary medicine as a diarrheal agent in pigs, PEC serves as an important model for the study...

Published: 7/25/2024 | Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot, Kyeong-Ok Chang

Keywords(s): CALICIVIRUS, cDNA, CLONE, Construction, DA4BXX, DAXXXX, DB4BXX, DBXXXX, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENTERIC, FULL-LENGTH, Genome, INFECTIOUS, PORCINE, RNA

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials

A Novel Rapid Point-of Care Diagnostic Method for Infectious and Autoimmune Diseases

Rapid point-of-care, antibody-based testing is not available for the diagnosis of autoimmune and most infectious diseases. For detecting autoantibodies associated with most autoimmune conditions, fluid-phase immunoprecipitation assays are required. However, these assays usually involve radioactivity and are not feasible for point-of-care applications....

Published: 7/25/2024 | Inventor(s): Peter Burbelo

Keywords(s): Autoimmune, Diagnosis, DISEASES, INFECTIOUS, Magnet, Methods, Neodymium, RAPID, VAXXXX, VFXXXX, VJXXXX, VKXXXX, VLXXXX, VQXXXX, WBXXXX, XAXXXX, XDXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX

Category(s): TherapeuticArea > Endocrinology, TherapeuticArea > Immunology, Application > Non-Medical Devices, Application > Medical Devices, TherapeuticArea > Geriatrics, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Diagnostics, ResearchProducts > Antibodies

Plasmid pNL4-3, HIV Clone For Easy Mutational Changes

Plasmid DNA (clone pNL4-3) that produces infectious HIV-1 virus particles in a wide variety of cells as described in the J Virol. 1986 Aug;59(2):284-91 and developed in the laboratory of Dr. Malcolm Martin at the National Institute of Allergy and Infectious Diseases.

Published: 7/25/2024 | Inventor(s): John Leonard, Malcolm Martin, Rosamond Rutledge-Burns, Theodore Theodore, Ronald Willey, Thomas Folks, Akio Adachi, Arnold Rabson

Keywords(s): 114, AIDS Research & Reference Reagent Program, CHANGES, CLONES, DDXXXX, DNA, EASY, HIV, INFECTIOUS, Listed LPM Ano as of 4/15/2015, MUTATIONAL, Novel, PLASMID, pNL4-3, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, VLXXXX, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease