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Compositions for Modification of Genomic DNA and Exogenous Gene Expression

A novel method of targeted insertion of transgenes at CLYBL locus directly in human cells is disclosed. Also, methods and compositions for increasing targeted insertion of a transgene into a specific location within the cell or increasing the frequency of gene modification in a targeted locus are disclosed. Genome modification by precise gene targeting...

Published: 7/30/2024 | Inventor(s): Mahendra Rao, Jizhong Zou

Keywords(s): Cl, Compositions, GB2BXX, GB2CXX, Genome, Harbor, LOCUS, Methods, MODIFICATION, SAFE, Targeted, VEXXXX, WIXXXX, WJXXXX, XEXXXX, YAXXXX, YBL, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Neurology

Novel Live-Attenuated Rabies Vaccine

The critical feature of this technology is the Evelyn-Rokitnicki-Abelseth (ERA) rabies whole genome DNA sequence. With the availability of the entire rabies genome, a recombinant vaccine can be developed using reverse genetics. Using this technology, CDC researchers have developed a recombinant, live-attenuated vaccine shown to confer protection against...

Published: 7/25/2024 | Inventor(s): Xianfu Wu, Charles Rupprecht

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Genome, Genomes, Method, OID-NCEZID-DHCPP, RELATED, Sequences, sequencing, viral, Whole

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines

Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis

CDC researchers developed a simple target-specific isothermal nucleic acid amplification technique, termed Genome Exponential Amplification Reaction (GEAR). The method employs a set of four primers (two inner and two outer). The outer primer pair targets three specific nucleic acid sequences at a constant 60°C, while the inner pair of primers accelerates...

Published: 7/25/2024 | Inventor(s): Prithiviraj Jothikumar, Vincent Hill, Jothikumar Narayanan

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC4XXX, AC5XXX, Acids, ACXXXX, amplification, AMPLIFYING, AXXXXX, DA1XXX, DA2XXX, DA3XXX, DA4XXX, DA5XXX, DAXXXX, DXXXXX, Exponential, Gear, Genome, Isothermal, Methods, Nucleic, REACTION, REAGENTS, UBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Diagnostics

Development of Dengue Virus Type 3 Vaccine Candidates

The disease burden associated with dengue virus infection has increased over the past several decades in the tropical and semi-tropical regions of the world, where over 2 billion people live at risk of dengue infection. Annually, there are an estimated fifty (50) to one hundred (100) million cases of dengue fever, making development of an effective...

Published: 7/25/2024 | Inventor(s): Joseph Blaney, Brian Murphy, Stephen Whitehead

Keywords(s): 1, 2, 3, 30, 3'-UTR, CANDIDATES, CONSISTING, Containing, Contiguous, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion, DELETIONS, Delta30, DEN4, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, Dervived, Development, DXXXXX, Either, Genome, Hepatitis A, Hepatitis D, Hepatitis E, Iin, MULTIPLE, Nucleotdies, Nucleotide, ONE, Q fever, Regions, THAN, TYPE, UAXXXX, UBXXXX, Vaccine, virus

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Construction of an Infectious Full-Length cDNA Clone of the Porcine Enteric Calicivirus RNA Genome

Porcine enteric calicivirus (PEC) is a member of the genus Sapovirus in the family Caliciviridae. This virus causes diarrheal illness in pigs, and is presently the only enteric calicivirus that can be grown in cell culture. In addition to its relevance to veterinary medicine as a diarrheal agent in pigs, PEC serves as an important model for the study...

Published: 7/25/2024 | Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot, Kyeong-Ok Chang

Keywords(s): CALICIVIRUS, cDNA, CLONE, Construction, DA4BXX, DAXXXX, DB4BXX, DBXXXX, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENTERIC, FULL-LENGTH, Genome, INFECTIOUS, PORCINE, RNA

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials

Full-Length cDNA Clone Representing the Consensus Sequence of the RNA Genome of a Human Norovirus (strain MD145-12) That Encodes Biologically Active Proteins

The invention provides for a full-length cloned cDNA copy of the RNA genome of a predominant norovirus strain (Genogroup II.4) designated MD145-12 that was associated with human gastrointestinal illness. The noroviruses, which were formerly known as "Norwalk-like" viruses are estimated to cause 23 million cases of acute gastroenteritis in the USA each...

Published: 4/8/2024 | Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot

Keywords(s): Active, Biological, cDNA, CLONE, CONSENSUS, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENCODES, FULL-LENGTH, Genome, Human, MD145-12, Norovirus, proteins, Respresenting, RNA, sequence, Strain, That

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials