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Mouse Model of STAT5 for the Drug Screen and the Research of Cancer and Autoimmunity

The invention is a STAT5 mutant mouse that can be used in research related to cancer, autoimmunity and infectious diseases as well as drug screening. The mouse model itself has multiple immunological defects resulting in formation of STAT5 dimers but not tetramers. It reports that only a minority of IL-2-modulated genes is regulated by STAT5 tetramers....

Published: 7/25/2024 | Inventor(s): Jian-xin Lin, Warren Leonard

Keywords(s): BINDING, CONSENSUS, Critical, DDXXXX, DXXXXX, FUNCTION, Identification, IMMUNE, motifs, Roles, STAT5, Tetramer, Tetramerization

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials

Full-Length cDNA Clone Representing the Consensus Sequence of the RNA Genome of a Human Norovirus (strain MD145-12) That Encodes Biologically Active Proteins

The invention provides for a full-length cloned cDNA copy of the RNA genome of a predominant norovirus strain (Genogroup II.4) designated MD145-12 that was associated with human gastrointestinal illness. The noroviruses, which were formerly known as "Norwalk-like" viruses are estimated to cause 23 million cases of acute gastroenteritis in the USA each...

Published: 4/8/2024 | Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot

Keywords(s): Active, Biological, cDNA, CLONE, CONSENSUS, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENCODES, FULL-LENGTH, Genome, Human, MD145-12, Norovirus, proteins, Respresenting, RNA, sequence, Strain, That

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials