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Development of a Transferrable Norwalk Virus Epitope and Detector Monoclonal Antibody

Noroviruses are now recognized as the major cause of non-bacterial gastroenteritis in all age groups, and efforts are underway to develop an effective vaccine. The lack of a robust cell culture system for human noroviruses has complicated vaccine development. Hence, norovirus virus like particles (VLPs) have played an important role in the understanding...

Published: 7/25/2024 | Inventor(s): Stanislav Sosnovtsev, Karin Bok, Carlos Sandoval-Jaime, Eugenio Abente, Gabriel Parra Gonzalez, Lisbeth Kim Green

Keywords(s): ANTIBODY, DA4BXX, DA4XXX, DAXXXX, DDXXXX, DETECTOR, DetectorMonoclonal, Development, DEXXXX, DXXXXX, Epitope, Listed LPM Fenn as of 4/15/2015, monoclonal, NORWALK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Transferrable, virus, VLXXXX, WBXXXX, WIXXXX, XAXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials, TherapeuticArea > Infectious Disease

Monoclonal Antibodies that Neutralize Norovirus

Vaccines and therapies to prevent and treat Norovirus infections do not exist, despite the worldwide prevalence of Norovirus infections. Outbreaks of human gastroenteritis attributable to Norovirus commonly occur in group setting, such as hospitals, nursing homes, schools, dormitories, cruise ships and military barracks. This technology relates to...

Published: 7/25/2024 | Inventor(s): Karin Bok, Stanislav Sosnovtsev, Lisbeth Kim Green, Robert Purcell, Zhaochun Chen

Keywords(s): antibodies, chimeric, Chimpanzee/Human, DB4BXX, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DXXXXX, Listed LPM Fenn as of 4/15/2015, monoclonal, Neutralize, NORWALK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, That, virus, VLXXXX, WJXXXX, WNXXXX, XAXXXX, XKXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Immunology, ResearchProducts > Antibodies

Single-Chain Antibodies Directed to Norovirus GI.1 and GII.4 and Their Use

Vaccines and therapies to prevent and treat Norovirus infections are not available, despite the worldwide prevalence of Norovirus infections. Outbreaks of human gastroenteritis attributable to Norovirus commonly occur in group settings, such as hospitals, nursing homes, schools, dormitories, cruise ships and military barracks. This application claims...

Published: 7/25/2024 | Inventor(s): Karin Bok, Stanislav Sosnovtsev, Lisbeth Kim Green, Gladys Parreno, Andrea Aguilar, Marina Bok, Lorena Garaicoechea

Keywords(s): DA4BXX, DA4XXX, DAXXXX, DB4BXX, DBXXXX, DD1XXX, DDXXXX, DEXXXX, diagnostic, Listed LPM Fenn as of 4/15/2015, Nanobodies, Norovirus, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Specific, therapeutic

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Diagnostics

Construction of Recombinant Baculoviruses Carrying the Gene Encoding the Major Capsid Protein, VP1, From Calicivirus Strains (Including Norovirus Strains Toronto, Hawaii, Desert Shield, Snow Mountain, and MD145-12)

The noroviruses (known as "Norwalk-like viruses") are associated with an estimated 23,000,000 cases of acute gastroenteritis in the United States each year. Norovirus illness often occurs in outbreaks, affecting large numbers of individuals, illustrated recently by well-publicized reports of gastroenteritis outbreaks on several recreational cruise...

Published: 7/25/2024 | Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green

Keywords(s): Baculoviruses, CALICIVIRUS, CAPSID, Construction, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, Hawaii, MD145-12, Mountain, Norovirus, SHIELD, Snow, STRAINS, TORONTO, VP1

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Diagnostics, Application > Vaccines, Application > Therapeutics

Construction of an Infectious Full-Length cDNA Clone of the Porcine Enteric Calicivirus RNA Genome

Porcine enteric calicivirus (PEC) is a member of the genus Sapovirus in the family Caliciviridae. This virus causes diarrheal illness in pigs, and is presently the only enteric calicivirus that can be grown in cell culture. In addition to its relevance to veterinary medicine as a diarrheal agent in pigs, PEC serves as an important model for the study...

Published: 7/25/2024 | Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot, Kyeong-Ok Chang

Keywords(s): CALICIVIRUS, cDNA, CLONE, Construction, DA4BXX, DAXXXX, DB4BXX, DBXXXX, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENTERIC, FULL-LENGTH, Genome, INFECTIOUS, PORCINE, RNA

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials

Enzymatically-Active RNA-Dependent RNA Polymerase From a Human Norovirus (Calicivirus)

The noroviruses (formerly known as “Norwalk-like viruses”) are associated with gastroenteritis outbreaks, affecting large numbers of individuals each year. Emerging data are supporting their increasing recognition as important agents of diarrhea-related morbidity and mortality. The frequency with which noroviruses are associated with gastroenteritis...

Published: 7/25/2024 | Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Kyeong-Ok Chang, Gael Belliot

Keywords(s): CALICIVIRUS, DA4BXX, DAXXXX, DB4BXX, DBXXXX, DC5BXX, DCXXXX, DDXXXX, DXXXXX, Enzymatically-active, Human, Norovirus, polymerase, RNA, RNA-Dependent

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease

Full-Length cDNA Clone Representing the Consensus Sequence of the RNA Genome of a Human Norovirus (strain MD145-12) That Encodes Biologically Active Proteins

The invention provides for a full-length cloned cDNA copy of the RNA genome of a predominant norovirus strain (Genogroup II.4) designated MD145-12 that was associated with human gastrointestinal illness. The noroviruses, which were formerly known as "Norwalk-like" viruses are estimated to cause 23 million cases of acute gastroenteritis in the USA each...

Published: 4/8/2024 | Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot

Keywords(s): Active, Biological, cDNA, CLONE, CONSENSUS, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENCODES, FULL-LENGTH, Genome, Human, MD145-12, Norovirus, proteins, Respresenting, RNA, sequence, Strain, That

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials