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Monoclonal Antibodies that Neutralize Norovirus

Vaccines and therapies to prevent and treat Norovirus infections do not exist, despite the worldwide prevalence of Norovirus infections. Outbreaks of human gastroenteritis attributable to Norovirus commonly occur in group setting, such as hospitals, nursing homes, schools, dormitories, cruise ships and military barracks. This technology relates to...

Published: 7/25/2024 | Inventor(s): Karin Bok, Stanislav Sosnovtsev, Lisbeth Kim Green, Robert Purcell, Zhaochun Chen

Keywords(s): antibodies, chimeric, Chimpanzee/Human, DB4BXX, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DXXXXX, Listed LPM Fenn as of 4/15/2015, monoclonal, Neutralize, NORWALK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, That, virus, VLXXXX, WJXXXX, WNXXXX, XAXXXX, XKXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Immunology, ResearchProducts > Antibodies

Humanized Monoclonal Antibodies Efficient for Neutralization of Tick-Borne Encephalitis Virus (TBEV)

TBEV causes serious illnesses from meningitis to meningo-encephalitis, totaling 3,000 cases of hospitalization in Europe and between 5,000-10,000 cases in Russia reported every year. The Far Eastern hemorrhagic TBEV strains are associated with a mortality rate (between 1-2%), higher than other strains isolated in the Siberia or Western Europe. There...

Published: 7/25/2024 | Inventor(s): Alexander Pletnev, Ching-juh Lai, Robert Purcell

Keywords(s): antibodies, ANTIBODY, Binding/Neutralization, Chimpanzee, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DDXXXX, DERIVED, DXXXXX, Efficient, ENCEPHALITIS, FAB, Fragments, HUMANIZED, monoclonal, TBEV, TICK-BORNE, virus

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Infectious Disease

Monoclonal Antibodies Against Poliovirus

Early work by Hammond at al. showed gamma globulin to be effective for the prevention of poliomyelitis. Therefore, passive immunotherapy could be another way to treat chronic excretors. Even though prior attempts to use intravenous immunoglobulin (IVIG) and breast milk were unsuccessful, there is reason to think that higher doses of antipoliovirus antibodies...

Published: 7/25/2024 | Inventor(s): Konstantin Chumakov, Robert Purcell, Zhaochun Chen

Keywords(s): antibodies, chimeric, Chimpanzee/Human, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DDXXXX, DEXXXX, DXXXXX, monoclonal, Neutralize, POLIOVIRUS, Serotypes, That, THREE

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Diagnostics, Application > Research Materials

Monoclonal Antibodies That React With the Capsule of Bacillus anthracis

Bacillus anthracis is the causative agent of anthrax and is surrounded by a polypeptide capsule of poly-gamma-D-glutamic acid (gammaDPGA). gammaDPGA is poorly immunogenic and has antiphagocytic properties. The bacterial capsule is essential for virulence. Antibodies to the capsule have been shown to enhance phagocytosis and killing of encapsulated...

Published: 7/25/2024 | Inventor(s): Robert Purcell, Rachel Schneerson, Joanna Kubler-kielb, Lily Zhongdong Dai, Zhaochun Chen

Keywords(s): Anthracis, Anthrax, antibodies, Autoimmune polyendocrinopathy syndrome, type 1, Bacillus, Capsule, chimeric, Chimpanzee/Human, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DDXXXX, DXXXXX, KILL, monoclonal, Opsonophagocytosis, ORGANISM, Patent Category - Biotechnology, PGA 1, PGA 2, REACT, Schmidt syndrome, That

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease

Humanized Monoclonal Antibodies that Specifically Bind Japanese Encephalitis Virus (JEV) and Their Use

Japanese encephalitis virus (JEV) is the prototype virus of the Japanese encephalitis (JE) group belonging to the Flavivirus genus of the Flaviviridae family. Other members of the group include Kunjin virus, St. Louis encephalitis virus, and West Nile encephalitis virus (WNV). JEV is widely distributed in South Asia, Southeast Asia, and the Asian Pacific...

Published: 7/25/2024 | Inventor(s): Robert Purcell, Ching-juh Lai, Ana Goncalvez

Keywords(s): Against, antibodies, BBXXXX, Chimpanezee, DA4BXX, DA4XXX, DAXXXX, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DDXXXX, DERIVED, DXXXXX, Efficient, Fabs, HUMANIZED, Infection, JAPANESE, Japanese encephalitis, JEV, Mice, monoclonal, Neutralization, Patent Category - Biotechnology, Protection, virus, Vitro

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Diagnostics, Application > Vaccines

Hepatitis C Virus Cell Culture System

Hepatitis C virus (HCV) infection causes chronic liver disease and is a major global health problem with an estimated 170 million people affected worldwide and 3-4 million new cases every year. Therapeutic advances will be greatly aided by the ability of researchers to successfully replicate and characterize the virus in vitro. The study of HCV replication...

Published: 7/25/2024 | Inventor(s): Rodney Russell, Robert Purcell, Suzanne Emerson

Keywords(s): Cells, CULTURE, DDXXXX, DXXXXX, Hepatitis A, HEPATITIS C, Hepatitis D, Hepatitis E, Hepatocellular carcinoma, adult, HEPATOMA, Huh-7, Huh-7.5, Subclone

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Research Materials

Monoclonal Antibodies Against Dengue and Other Viruses With Deletion in Fc Region

The four dengue virus (DENV) serotypes (DENV-1 to DENV-4) are the most important arthropod-borne flaviviruses in terms of morbidity and geographic distribution. Up to 100 million DENV infections occur every year, mostly in tropical and subtropical areas where vector mosquitoes are abundant. Infection with any of the DENV serotypes may be asymptomatic...

Published: 7/25/2024 | Inventor(s): Robert Purcell, Ching-juh Lai, Ana Goncalvez

Keywords(s): (4)r syndrome, Against, antibodies, C syndrome, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, Chromosome 7, monosomy, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DDXXXX, Deletion, Deletion 7, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, DXXXXX, FC, G syndrome, Hemorrhagic fever, Hypertelorism with esophageal abnormality and hypospadias, monoclonal, N syndrome, Q fever, R(6) syndrome, R(7) syndrome, Region, Syndrome X, UAXXXX, UBXXXX, Viruses, W syndrome, W syndrome; Syndrome W

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Vaccines, Application > Therapeutics

Monoclonal Antibodies Against Orthopoxviruses

Concerns that variola (smallpox) virus might be used as a biological weapon have led to the recommendation of widespread vaccination with vaccinia virus. While vaccination is generally safe and effective for prevention of smallpox, it is well documented that various adverse reactions in individuals have been caused by vaccination with existing licensed...

Published: 7/25/2024 | Inventor(s): Bernard Moss, Suzanne Emerson, Robert Purcell, Patricia Earl, Zhaochun Chen

Keywords(s): Against, antibodies, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, monoclonal, ORTHOPOXVIRUSES

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease

Monoclonal Antibodies that Neutralize B. anthracis Protective Antigen (PA), Lethal Factor (LF) and Edema Factor (EF)

Anthrax, whether resulting from natural or bioterrorist-associated exposure, is a constant threat to human health. The lethality of anthrax is primarily the result of the effects of anthrax toxin, which has 3 components: a receptor-binding protein known as "protective antigen" (PA) and 2 catalytic proteins known as "lethal factor" (LF) and "edema factor"...

Published: 7/25/2024 | Inventor(s): Stephen Leppla, Suzanne Emerson, Robert Purcell, Mahtab Moayeri, Zhaochun Chen

Keywords(s): Anthrax, antibodies, ANTIBODY, ANTIGEN, Chimpaneze, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DDXXXX, DXXXXX, Edema, FACTORS, Lethal, monoclonal, Neutralize, Neutralizes, PA, Protective, That, toxin, UAXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, Application > Therapeutics, TherapeuticArea > Infectious Disease

Swine Hepatitis E Virus Available For Use in Diagnosis, Prevention and Treatment of Hepatitis E

Hepatitis E virus (HEV) is the cause of Hepatitis E, a liver disease that occurs primarily in developing countries due to fecal contaminated drinking water. Outbreaks of HEV infection have caused epidemics in Africa, Central and Southeast Asia and Mexico and cases of the disease have also been reported sporadically in more developed countries. Hepatitis...

Published: 7/25/2024 | Inventor(s): Suzanne Emerson, Robert Purcell, Xiang-jin Meng

Keywords(s): DC5BXX, DC5XXX, DCXXXX, Duke DNA Project, DXXXXX, e, Hepatitis, Hepatitis A, Hepatitis D, Hepatitis E, HEV, PCT/US98/14665, Swine, THEREOF, UAXXXX, USES, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Vaccines

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