Search Results - monoclonal

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High-Affinity Mouse Monoclonal Antibodies to GPC-3 for Liver Cancer Research

Abstract: The National Cancer Institute Laboratory of Molecular Biology seeks parties for collaborative research to co-develop and commercialize antibody drug/toxin conjugates as liver cancer therapy and diagnostics. There is great interest and value in developing more sensitive and efficient agents for earlier detection of hepatocellular cancer (HCC). ...

Published: 5/21/2024 | Inventor(s): Mitchell Ho, Yen Phung, Wei Gao, Yifan Zhang

Keywords(s): ANTIBODY, GLYCOPROTEIN, Glypican-3, GPC3, HCC, hepatocellular carcinoma, liver, monoclonal

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing

Human and Improved Murine Monoclonal Antibodies Against CD22

Abstract: CD22 is a common cell surface glycoprotein expressed in B-cells and present in B-cell lymphomas; e.g., hairy cell leukemia (HCL), non-Hodgkins lymphoma (NHL), chronic lymphoblastic leukemia (CLL), and other cancers. It is therefore a target for cancer immunotherapy. Conjugation of anti-CD22 monoclonal antibodies with toxins or drugs has shown...

Published: 8/14/2024 | Inventor(s): Dimiter Dimitrov, Xiaodong Xiao, Ira Pastan

Keywords(s): antibodies, ANTIGEN, B-CELL, B-Cell Lymphoma, Bcl, CANCER, CD22, Chronic Lymphoblastic Leukemia, CLL, Dimitrov, Hairy cell leukemia, HCL, Human, monoclonal, NHL, non-Hodgkins lymphoma, Oncology

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

A Rabbit Anti-pT1989 ATR Monoclonal Antibody for Use in Immunoassays

Abstract: Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is essential for regulating DNA damage checkpoints during the cell cycle. ATR, is phosphorylated at threonine 1989 site (T1989) in response to DNA damage and ATR activation leads to activation of downstream substrates, signaling cascades and cell cycle arrest. ATR is a potential...

Published: 4/8/2024 | Inventor(s): Thomas Pfister, Allison Marrero, Ralph Parchment, James Doroshow, Robert Kinders

Keywords(s): ANTIBODY, assay, Ataxia telangiectasia mutated and Rad3-related kinase, CANCER, diagnostic, DNA checkpoint, monoclonal

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics

Monoclonal Antibody Fragments for Targeting Therapeutics to Growth Plate Cartilage

Abstract: A child's growth is dependent on the proper functioning of the growth plate, a specialized cartilage structure located at the ends of long bones and within the vertebrae. The primary function of the growth plate is to generate new cartilage, which is then converted into bone tissue and results in the lengthening of bones. Failure of the growth...

Published: 4/8/2024 | Inventor(s): Jeffrey Baron, Sao Fong (Crystal) Cheung, Chun Lui, Dimiter Dimitrov, Zhongyu Zhu

Keywords(s): Anti-mantrilin-3 Antibody, ARTHRITIS, Baron, Cartilage, Dimitrov, Eunice Kennedy Shriver National Institute on Child Health an, Growth plate, Human Growth Hormone, monoclonal, NICHD, OSTEOARTHRITIS, Short Stature, Skeletal Dysplasia

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Monoclonal Antibody Against Human Alpha-5 Integrin that Does Not Disrupt Adhesive Function

This technology includes a rat monoclonal antibody termed mAb11 was generated against the human alpha-5 integrin subunit and can provide immunological characterizations without disrupting integrin adhesive function. It permits characterization of its localization even if the receptor is bound to its fibronectin ligand. The antibody is commercially available...

Published: 7/25/2024 | Inventor(s): Steven Akiyama, Susan Yamada, Kenneth Yamada

Keywords(s): Against, Alpha-5, ANTIBODY, DISRUPT, DOES, FUNCTION, Human, INTEGRIN, monoclonal, That, WIXXXX, XAXXXX

Category(s): Application > Research Materials, ResearchProducts > Antibodies, TherapeuticArea > Immunology

Monoclonal Antibodies To Prevent or Treat SARS-CoV-2 Infection

The ongoing COVID-19 pandemic, caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2), has created an immense public health, social, and economic burden. Variants of concern continue to emerge that have increased transmissibility, pathogenicity, or both and that reduce the effectiveness of current therapeutics and vaccines. Thus, there is...

Published: 7/25/2024 | Inventor(s): Patrizia Farci, Kamille West, Peng Zhang, Paolo Lusso, Zhaochun Chen

Keywords(s): antibodies, Cure, Disease, monoclonal, Prevent, SARS-CoV-2

Category(s): Collaboration Sought > Collaboration

Human Monoclonal and Bispecific Antibodies Targeting SARS-CoV-2 Coronavirus

SARS-CoV-2 is a virus of the Coronavirus family that has emerged as a major public health concern. The first cases of SARS-CoV-2 were reported in China and rapidly spread worldwide leading to a global pandemic. The highest morbidity and mortality have been reported in the elderly and immunocompromised. Antibody therapeutics have great importance for...

Published: 7/25/2024 | Inventor(s): Peter Crompton, Hyeseon Cho, Kristina Gonzales-Wartz, Mary Peter, Joshua Tan

Keywords(s): antibodies, Human, monoclonal, SARS-CoV-2, Targeting

Category(s): Collaboration Sought > Collaboration

Monoclonal Antibodies for Specific Detection of Dengue Virus Sub-type 4 in Human Serum

Dengue Virus (DENV) non-structural protein 1 (NS1) is secreted in blood during the acute phase of viremic DENV infection. While there are commercially available ELISA assays for DENV NS1 detection, these tests have limited sensitivity (50-70%), do not determine the serotype of the infecting DENV, do not detect all four serotypes equally, or are less...

Published: 7/25/2024 | Inventor(s): Tesfaye Taye, Elizabeth Hunsperger

Keywords(s): 1, 4, antibodies, DENGUE, DENV, monoclonal, NCEZID, NCEZID-DVBD, Non-structural, NS1, Protein, Serotype, Specific, virus, VLXXXX, WBXXXX, WHXXXX, WIXXXX, XAXXXX, XEXXXX, YBXXXX, YDXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Antibodies, Application > Diagnostics

Zika Virus NS1 Protein Monoclonal Antibodies for Research, Development, and Novel Diagnostics

Zika virus is a flavivirus that is spread by the bite of infected Aedes mosquitoes. The current outbreak and swift dissemination/spread of Zika virus (ZIKV) and its linkage to birth defects and neurological syndromes has prompted the development of novel diagnostic tests. Because ZIKV is serologically similar to other flaviviruses such as dengue virus...

Published: 7/25/2024 | Inventor(s): Dennis Bagarozzi, Jason Goldstein

Keywords(s): antibodies, Development, Diagnostics, monoclonal, NCEZID, NCEZID-DSR, Novel, virus, VLXXXX, WBXXXX, WIXXXX, XAXXXX, YBXXXX, Zika

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Antibodies

Heartland Virus Humanized Monoclonal Antibodies for Diagnostic and Therapeutic Development

Heartland virus (HRTV) is a novel tick-borne virus first discovered in 2009 that causes flu-like symptoms such as fever, headaches, fatigue, muscle aches, and diarrhea. Patients with HRTV often have low white blood cell counts, low platelet counts, and abnormal liver function tests which can become severe. Cases of Heartland virus disease have been...

Published: 7/25/2024 | Inventor(s): Aaron Brault, Amanda Calvert

Keywords(s): antibodies, Diagnostics, heartland, Listed LPM Houze as of 4/15/2015, monoclonal, NCEZID, NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Specific, therapeutics, virus, WBXXXX, WFXXXX, WJXXXX, XAXXXX, YAXXXX, YBXXXX, YCXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Antibodies, Application > Occupational Safety and Health, Application > Therapeutics, Application > Consumer Products, Application > Diagnostics

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