Search Results - ncezid

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Monoclonal Antibodies for Specific Detection of Dengue Virus Sub-type 4 in Human Serum

Dengue Virus (DENV) non-structural protein 1 (NS1) is secreted in blood during the acute phase of viremic DENV infection. While there are commercially available ELISA assays for DENV NS1 detection, these tests have limited sensitivity (50-70%), do not determine the serotype of the infecting DENV, do not detect all four serotypes equally, or are less...

Published: 7/25/2024 | Inventor(s): Tesfaye Taye, Elizabeth Hunsperger

Keywords(s): 1, 4, antibodies, DENGUE, DENV, monoclonal, NCEZID, NCEZID-DVBD, Non-structural, NS1, Protein, Serotype, Specific, virus, VLXXXX, WBXXXX, WHXXXX, WIXXXX, XAXXXX, XEXXXX, YBXXXX, YDXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Antibodies, Application > Diagnostics

Zika Virus NS1 Protein Monoclonal Antibodies for Research, Development, and Novel Diagnostics

Zika virus is a flavivirus that is spread by the bite of infected Aedes mosquitoes. The current outbreak and swift dissemination/spread of Zika virus (ZIKV) and its linkage to birth defects and neurological syndromes has prompted the development of novel diagnostic tests. Because ZIKV is serologically similar to other flaviviruses such as dengue virus...

Published: 7/25/2024 | Inventor(s): Dennis Bagarozzi, Jason Goldstein

Keywords(s): antibodies, Development, Diagnostics, monoclonal, NCEZID, NCEZID-DSR, Novel, virus, VLXXXX, WBXXXX, WIXXXX, XAXXXX, YBXXXX, Zika

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Antibodies

Heartland Virus Humanized Monoclonal Antibodies for Diagnostic and Therapeutic Development

Heartland virus (HRTV) is a novel tick-borne virus first discovered in 2009 that causes flu-like symptoms such as fever, headaches, fatigue, muscle aches, and diarrhea. Patients with HRTV often have low white blood cell counts, low platelet counts, and abnormal liver function tests which can become severe. Cases of Heartland virus disease have been...

Published: 7/25/2024 | Inventor(s): Aaron Brault, Amanda Calvert

Keywords(s): antibodies, Diagnostics, heartland, Listed LPM Houze as of 4/15/2015, monoclonal, NCEZID, NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Specific, therapeutics, virus, WBXXXX, WFXXXX, WJXXXX, XAXXXX, YAXXXX, YBXXXX, YCXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Antibodies, Application > Occupational Safety and Health, Application > Therapeutics, Application > Consumer Products, Application > Diagnostics

West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Development

Zika virus (ZIKV) is a flavivirus primarily transmitted by infected Aedes mosquitoes. Infection with ZIKV during pregnancy can affect the fetus causing microcephaly, neurological complications, and other birth defects. Adults are also at risk of developing Guillain-Barre syndrome and other neurological disorders from ZIKV infection. In response to the...

Published: 7/25/2024 | Inventor(s): Claire Kinney

Keywords(s): assay, Chimera, Development, INACTIVATED, NCEZID, NCEZID-DVBD, Neutralization, Nile/Zika, Vaccine, VLXXXX, WBXXXX, West, WIXXXX, WNXXXX, XEXXXX, XHXXXX, XKXXXX, YBXXXX, Zika

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials, ResearchProducts > Research Equipment

Real-Time RT-PCR Assay for the Rapid Detection of Rabies and Other Lyssaviruses

Rabies occurs in more than 150 countries and territories, resulting in at least 55,000 human deaths per year worldwide according to World Health Organization estimates. Rabies is a vaccine-preventable viral disease caused by numerous lyssaviruses that are found in a variety of animal species throughout the world. Rabies virus infects the central nervous...

Published: 7/25/2024 | Inventor(s): Yu Li

Keywords(s): assay, DA4XXX, DDXXXX, Diagnostics, LYSSAVIRUSES, Modified, NCEZID, NCEZID-DHCPP, Non-rabies, Probe, rabies, REAL-TIME, RT-PCR, VLXXXX, VOXXXX, WBXXXX, WGXXXX, WHXXXX, WIXXXX, XEXXXX, YBXXXX, YGXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Nucleic Acid Primers and Probes for Detecting Ebola Virus (species Zaire ebolavirus)

The 2014-2016 Ebola Virus Disease (EVD) outbreak in West Africa was the largest in history, causing more than 28,000 suspected, probable, and confirmed infections and more than 11,000 deaths across nine countries. CDC scientists designed nucleic acid primers and probes which can be used in a sensitive test for detecting all known strains of Ebola virus...

Published: 7/25/2024 | Inventor(s): Tara Sealy, Ute Stroeher, Stuart Nichol, Jonathan Towner

Keywords(s): 7, Acid, antibodies, ANTIGENS, assay, DETECTING, Detection, Ebola, Ebolavirus, ELISA, Enzyme, Identification, immunosorbent, LINKED, Listed LPM Kirby as of 4/15/2015, Mab, monoclonal, Mouse, NCEZID, NCEZID-DHCPP, Nucleic, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PRIMERS, Probes, Species, Used, virus, Viruses, Zaire

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

CDC Trioplex – A Real-Time RT-PCR Assay for the Diagnosis of Zika, and Differentiation from Dengue & Chikungunya Virus Infections

As of March 2017, 64 countries and territories had travel notices for active Zika virus transmissions. CDC developed the Trioplex rRT-PCR test to detect evidence of Zika virus infection and aid in differentiating this infection from dengue and chikungunya virus infections, all of which are spread by the same types of Aedes species mosquitoes and cause...

Published: 7/25/2024 | Inventor(s): Robert Lanciotti, Gilberto Santiago, Jorge Munoz-Jordan

Keywords(s): assay, NCEZID, NCEZID-DVBD, REAL-TIME, RT-PCR, Trioplex

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing