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West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Development

Zika virus (ZIKV) is a flavivirus primarily transmitted by infected Aedes mosquitoes. Infection with ZIKV during pregnancy can affect the fetus causing microcephaly, neurological complications, and other birth defects. Adults are also at risk of developing Guillain-Barre syndrome and other neurological disorders from ZIKV infection. In response to the...

Published: 7/25/2024 | Inventor(s): Claire Kinney

Keywords(s): assay, Chimera, Development, INACTIVATED, NCEZID, NCEZID-DVBD, Neutralization, Nile/Zika, Vaccine, VLXXXX, WBXXXX, West, WIXXXX, WNXXXX, XEXXXX, XHXXXX, XKXXXX, YBXXXX, Zika

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials, ResearchProducts > Research Equipment

Zika Virus Vaccines

Zika virus (ZIKV) is a flavivirus transmitted by mosquitos that is strongly linked to neurological complications including Guillain-Barré syndrome, meningoencephalitis, and microcephaly. The association between active ZIKV infection during pregnancy and microcephaly and intrauterine growth retardation in the fetus has been confirmed in murine models...

Published: 7/25/2024 | Inventor(s): John Mascola, Wing-pui Kong, Eun Yang, Wei Shi, Theodore Pierson, Leda Castilho, Kimberly Dowd, Lingshu Wang, Christina Demaso, Rebecca Pelc, Adrian Creanga, Julie Ledgerwood, Sebastian Ramesch, Barney Graham

Keywords(s): Chimera, DC5BXX, GENE-BASED, JAPANESE ENCEPHALITIS VIRUS, vaccines, virus-like particles, VLP, Zika

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease