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Novel Human Rotavirus Vaccine CDC-6 Strain for Impacted Subgroup, the Lewis Negative Population
Rotaviral infection is the most common gastrointestinal illness of children in the world, affecting both developed and developing economies. There is no specific drug treatment for rotavirus infection. Vaccination and good hygiene are key to prevention. Approximately 5-10% of the world's population are Lewis histoblood group antigen negative, that percentage...
Published: 7/25/2024   |   Inventor(s): Yuhuan Wang, Baoming Jiang
Keywords(s): Candidate, CHARACTERIZATION, G9P[6], Human, Isolation, NCIRD, NCIRD-DVD, rotavirus, Strain, Vaccine, VLXXXX, WBXXXX, WFXXXX, WGXXXX, WHXXXX, WIXXXX, WNXXXX, XKXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Consumer Products, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health
West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Development
Zika virus (ZIKV) is a flavivirus primarily transmitted by infected Aedes mosquitoes. Infection with ZIKV during pregnancy can affect the fetus causing microcephaly, neurological complications, and other birth defects. Adults are also at risk of developing Guillain-Barre syndrome and other neurological disorders from ZIKV infection. In response to the...
Published: 7/25/2024   |   Inventor(s): Claire Kinney
Keywords(s): assay, Chimera, Development, INACTIVATED, NCEZID, NCEZID-DVBD, Neutralization, Nile/Zika, Vaccine, VLXXXX, WBXXXX, West, WIXXXX, WNXXXX, XEXXXX, XHXXXX, XKXXXX, YBXXXX, Zika
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials, ResearchProducts > Research Equipment
Chimeric Dengue/Zika Viruses for Live-Attenuated Zika Vaccine Development
Zika virus (ZIKV) can be passed from a pregnant woman to her fetus. Infection during pregnancy can cause microcephaly and other severe birth defects. Currently, there are no vaccines to prevent or medications to treat Zika infections. CDC engineered chimeric Zika viruses on the dengue virus (DENV) sub-type 2 (D2) PDK-53 vaccine backbone (D2 PDK-53)...
Published: 7/25/2024   |   Inventor(s): Claire Kinney
Keywords(s): chimeric, Dengue/Zika, Development, Live-Attenuated, NCEZID-DVBD, Vaccine, Viruses, VLXXXX, WBXXXX, WIXXXX, WNXXXX, XEXXXX, XKXXXX, YAXXXX, YBXXXX, Zika
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Vaccines, Application > Research Materials
Neutralizing Antibodies to Influenza HA and Their Use and Identification
The effectiveness of current influenza vaccines varies by strain and season, in part because influenza viruses continuously evolve to evade human immune responses. While the majority of seasonal influenza infections cause relatively mild symptoms, each year influenza virus infections result in over 500,000 hospitalizations in the United States and Europe....
Published: 7/25/2024   |   Inventor(s): Robert Bailer, Michael Joyce, John Mascola, Peter Kwong, Sarah Andrews, Paul Thomas, Gwo-Yu Chuang, Adam Wheatley, Yi Zhang, James Whittle, Adrian McDermott
Keywords(s): 1, 2, antibodies, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DXXXXX, GROUP, INFLUENZA, Neutralize, That, Their, Viruses, VLXXXX, WJXXXX, WNXXXX, XAXXXX, XKXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, ResearchProducts > Antibodies, TherapeuticArea > Immunology
Prevention or Treatment of Viral Infections by Inhibition of the Histone Methyltransferases EZH1/2
Herpes simplex viral infections, including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), are exceptionally common worldwide. These viruses establish lifelong persistent infections with cycles of lytic reactivation to produce recurrent diseases including oral and genital lesions, herpetic keratitis/blindness, congenital-developmental syndromes,...
Published: 7/25/2024   |   Inventor(s): Jesse Arbuckle, Thomas Kristie
Keywords(s): DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DEXXXX, DXXXXX, EZH1/2, HERPESVIRUS, Infection, Inhibitors, Latency, Listed LPM Fenn as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Reactivation, Suppresses, VLXXXX, WKXXXX, WNXXXX, XKXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease
A Novel Virus-Based Expression System
The present invention is related to a recombinant viral vector for vaccines. Currently available poxvirus vectors for humans and other animals exhibit suboptimal expression of recombinant gene(s) and high expression of vector proteins which causes weak immunogenicity and high anti-vector immune response. The present novel virus-based expression vectors...
Published: 7/25/2024   |   Inventor(s): Linda Wyatt, Bernard Moss
Keywords(s): Expression, Gene, GENES, High, LOW, Non-Replicating, System, TARGET, vaccinia, Vector, virus, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WIXXXX, WNXXXX, XEXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics
Monoclonal Antibodies that Neutralize Norovirus
Vaccines and therapies to prevent and treat Norovirus infections do not exist, despite the worldwide prevalence of Norovirus infections. Outbreaks of human gastroenteritis attributable to Norovirus commonly occur in group setting, such as hospitals, nursing homes, schools, dormitories, cruise ships and military barracks. This technology relates to...
Published: 7/25/2024   |   Inventor(s): Karin Bok, Stanislav Sosnovtsev, Lisbeth Kim Green, Robert Purcell, Zhaochun Chen
Keywords(s): antibodies, chimeric, Chimpanzee/Human, DB4BXX, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DXXXXX, Listed LPM Fenn as of 4/15/2015, monoclonal, Neutralize, NORWALK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, That, virus, VLXXXX, WJXXXX, WNXXXX, XAXXXX, XKXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Immunology, ResearchProducts > Antibodies
Recombinant Vaccines Based on Poxvirus Vectors
The technology offered for licensing is foundational in the area of recombinant DNA vaccines. In the last several years, facilitated through a licensing program of the NIH, the technology has been broadly applied in the development and commercialization of several novel human and veterinary vaccines in the areas of infectious disease as well as cancer...
Published: 7/25/2024   |   Inventor(s): Bernard Moss
Keywords(s): B, BBXXXX, BCXXXX, DC5BXX, DC5XXX, DCXXXX, Duke DNA Project, Hepatitis, INFLUENZA, POX VIRUS, rabies, recombinant, vaccines, vaccinia, virus, VLXXXX, VOXXXX, WNXXXX, XKXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Consumer Products, TherapeuticArea > Infectious Disease
Live Attenuated Vaccine to Prevent Disease Caused by West Nile Virus
West Nile virus (WNV) has recently emerged in the U.S. and is considered a significant emerging disease that has embedded itself over a considerable region of the U.S. WNV infections have been recorded in humans as well as in different animals. From 1999-2014, WNV killed 1,765 people in the U.S. and caused severe disease in more than 41,762 others....
Published: 7/25/2024   |   Inventor(s): Robert Chanock (Estate), Joseph Putnak, Brian Murphy, Joseph Blaney, Stephen Whitehead, Alexander Pletnev
Keywords(s): Chimeras, DC5BXX, DC5XXX, DCXXXX, DENGUE, Dengue (Flaviviridae), DXXXXX, Live, Nile, Vaccine, virus, VLXXXX, VOXXXX, WAXXXX, WBXXXX, West, WEST NILE VIRUS, WMXXXX, WNXXXX, XKXXXX, YCXXXX, YDXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Diagnostics
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