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Mononegavirales Vectors Expressing Chimeric Antigens

Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide, and also is an important cause of morbidity and mortality in the elderly. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use...

Published: 7/25/2024 | Inventor(s): Linda Brock, Ursula Buchholz, Peter Collins, Shirin Munir

Keywords(s): Added, Attenuated, DA4BXX, DA4XXX, DC5BXX, DC5XXX, DCXXXX, DD1XXX, DDXXXX, DEXXXX, DXXXXX, Expressing, F, Fusion, Gene, Highly, Human, Immunogenic, Macaques, MPV, Murine, PNEUMONIA, Protein, respiratory, RHESUS, RSV, Syncytial, virus

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Recombinant Chimeric Bovine/Human Parainfluenza Virus 3 Expressing SARS-CoV-2 Spike Protein and Its Use

Vaccines for SARS-CoV-2 are increasingly available under emergency use authorizations; however, indications are currently limited to individuals twelve (12) years or older. They also involve intramuscular immunization, which does not directly stimulate local immunity in the respiratory tract, the primary site of SARS-CoV-2 infection, shedding and spread....

Published: 7/25/2024 | Inventor(s): Shirin Munir, Cindy Luongo, Peter Collins, Cyril Le Nouen, Xueqiao Liu, Ursula Buchholz

Keywords(s): 2, ACUTE, Attenuated, B/HPIV3, BOVINE/HUMAN, chimeric, CORONAVIRUS, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DEXXXX, DXXXXX, Expression, GLYCOPROTEIN, PIV3, respiratory, S, SARS-CoV-2, SEVERE, spike, Syndrome

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Research Materials

Mononegavirales Vectors expressing Chimeric Antigens

Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use of murine pneumonia virus (MPV), a virus to which humans normally are not...

Published: 7/25/2024 | Inventor(s): Peter Collins, Ursula Buchholz, Linda Brock, Shirin Munir

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Vaccines, TherapeuticArea > Infectious Disease

Real-time RT-PCR assay for Detection of Live Attenuated Influenza Vaccine for A and B Viruses

Upon intranasal vaccination, live attenuated influenza vaccine (LAIV) viruses may replicate within the nose for several days. Current clinical diagnostic tests cannot distinguish between LAIV viruses and multiple influenza viruses in recently inoculated patients that present with respiratory symptoms. This poses a problem for the diagnosis and treatment...

Published: 7/25/2024 | Inventor(s): Stephen Lindstrom, Kai-Hui Wu, LaShondra Berman, Christine Warnes, Bo Shu

Keywords(s): assay, Assays., Attenuated, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DA4XXX, Detection, Human, Including, INFLUENZA, LAIV, LAIV-A, LAIV-B, Listed LPM Surabian as of 4/15/2015, Live, NCIRD-ID, PCR, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, REAL-TIME, respiratory, RT-PCR, SPECIMENS, States., United, Vaccine, Viruses, VLXXXX, WBXXXX, WIXXXX, XEXXXX, XHXXXX, YDXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Diagnostics, Application > Research Materials, ResearchProducts > Research Equipment

Biological/Research Material for H1N1 Influenza Virus Vaccine Research

Offered for licensing is a recombinant attenuated vaccinia virus, MVA, that expresses the haemagglutinin (HA) and nucleoprotein (NP) of influenza virus A/PR/8/34 (H1N1). The virus has been shown to stimulate protective immunity to influenza virus in mice. The materials can be used for research purposes and in particular in the area of influenza virus...

Published: 7/25/2024 | Inventor(s): Linda Wyatt, Bernard Moss

Keywords(s): A/PR/8/34, Attenuated, AXXXXX, DCXXXX, DDXXXX, DXXXXX, EXPRESSES, H1N1, Ha, Haemagglutinin, INFLUENZA, MVA, Np, NUCLEOPROTEIN, RESEARCH MATERIAL, That, vaccinia, virus

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Vaccines, TherapeuticArea > Infectious Disease

Respiratory Syncytial Virus (RSV) Vaccines Based on Promoter-Proximate Attenuation

Available for licensing and commercial development is a patent estate and related biological materials for producing therapeutic or prophylactic vaccines against Respiratory Syncytial Virus (RSV). The claimed vaccine strategy relates to the engineering and creation of live-attenuated RSV vaccine candidates by shifting the position of one or more viral...

Published: 7/25/2024 | Inventor(s): Peter Collins, Brian Murphy, Ursula Buchholz, Stephen Whitehead, Christine Krempl

Keywords(s): ATTENUATE, Attenuated, ATTENUATING, ATTENUATION, Chromosome 7, monosomy, DC5BXX, DC5XXX, DCXXXX, Deletion 7, DXXXXX, GENES, Noonan syndrome, NS1, Promoter-proximal, RSV, RSV virus, RSV/PIV, Syncytial, Vaccine, Vaccine Design, VACCINE DEVELOPMENT, VACCINE VECTORS, vaccines, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines

Live Attenuated Zika Virus Vaccine

This application claims live attenuated Zika viruses and vaccines, attenuated chimeric Zika viruses and vaccines, and multivalent immunogenic compositions comprising Zika vaccines and vaccines for other flaviviruses. The chimeric Zika viruses claimed include a first nucleotide sequence encoding at least one structural protein from a Zika virus (ZIKV),...

Published: 7/25/2024 | Inventor(s): Sara Woodson, Anna Durbin, Alexander Pletnev, Konstantin Tsetsarkin, Stephen Whitehead

Keywords(s): Attenuated, CANDIDATES, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, Live, Vaccine, virus, Zika

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Vaccines, Application > Research Materials, TherapeuticArea > Infectious Disease