Search Results - immunogenic

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T-Cell Therapy Against Patient-Specific Cancer Mutations

Abstract: Human cancers contain genetic mutations that are unique to each patient. Some of the mutated peptides are immunogenic, can be recognized by T cells, and therefore, may serve as therapeutic targets. Scientists at the National Cancer Institute's Surgery Branch developed a method to identify T cells that specifically recognize immunogenic mutations...

Published: 4/8/2024 | Inventor(s): Eric Tran, Yong-Chen Lu, Paul Robbins, Steven Rosenberg

Keywords(s): Cholangiocarcinoma, Immunogenic, Rosenberg, T-cell, Tran

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

T-Cell Therapy Against Patient-Specific Cancer Mutations

Published: 4/8/2024 | Inventor(s): Eric Tran, Paul Robbins, Yong-Chen Lu, Steven Rosenberg

Keywords(s): Cholangiocarcinoma, Immunogenic, T cell, T-cell

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Novel Inactivated Zika Vaccine Candidate Based on Purified Wild-type Zika Virus — for Zika Vaccine and Diagnostic Assay Development

Zika virus (ZIKV) spreads to people primarily through bite by infected Aedes mosquitoes. ZIKV infection during pregnancy can cause stillbirths or affect the fetus by causing serious birth defects, such as microcephaly and other brain defects. Although uncommon, adults with ZIKV can also develop Guillain-Barre syndrome and other neurological disorders....

Published: 4/8/2024 | Inventor(s): Holli Giebler, Windy Baldwin, Claire Kinney, Jill Livengood

Keywords(s): Compositions, Immunogenic, Methods, SAME, vaccines, YBXXXX, YCXXXX, YDXXXX, YXXXXX, Zika

Category(s):

Mononegavirales Vectors Expressing Chimeric Antigens

Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide, and also is an important cause of morbidity and mortality in the elderly. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use...

Published: 7/25/2024 | Inventor(s): Linda Brock, Ursula Buchholz, Peter Collins, Shirin Munir

Keywords(s): Added, Attenuated, DA4BXX, DA4XXX, DC5BXX, DC5XXX, DCXXXX, DD1XXX, DDXXXX, DEXXXX, DXXXXX, Expressing, F, Fusion, Gene, Highly, Human, Immunogenic, Macaques, MPV, Murine, PNEUMONIA, Protein, respiratory, RHESUS, RSV, Syncytial, virus

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease

Mononegavirales Vectors expressing Chimeric Antigens

Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use of murine pneumonia virus (MPV), a virus to which humans normally are not...

Published: 7/25/2024 | Inventor(s): Peter Collins, Ursula Buchholz, Linda Brock, Shirin Munir

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Vaccines, TherapeuticArea > Infectious Disease

Multi-Antigenic Peptide(s) Vaccine and Immunogen for Conferring Streptococcus pneumoniae Immunity

Disease caused by Streptococcus pneumoniae (pneumococcus) is an important cause of morbidity and mortality in the United States and developing countries. Pneumococcal disease is prevalent among the very young, the elderly and immunocompromised individuals. This invention is an improved, immunogenic peptide construct consisting of a combination of...

Published: 7/25/2024 | Inventor(s): George Carlone, Jacquelyn Sampson, Scott Johnson, Danny Jue, Edwin Ades

Keywords(s): Against, ANTIGENIC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DC4XXX, DCXXXX, DXXXXX, Epitope, Immunogenic, MULTIPLE, OID-NCIRD-DBD, Peptides, PNEUMONIA, PNEUMONIAE, Streptococcus, VJXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, WJXXXX, XAXXXX, XCXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Ophthalmology, Application > Diagnostics, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Consumer Products, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics, Application > Occupational Safety and Health, ResearchProducts > Antibodies, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease

Immunogenic Hepatitis E Virus Polypeptides for Vaccine and Diagnostics Development

This technology comprises specific hepatitis E virus (HEV) antigenic polypeptides. HEV causes epidemic and sporadic cases of hepatitis outbreaks with a mortality rate as high as 20% for pregnant women. In order to address this problem, CDC scientists carried out thorough HEV antigen screenings and subsequently developed recombinant proteins that efficiently...

Published: 4/8/2024 | Inventor(s): Yury Khudyakov, Jihong Meng, Howard Fields

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DXXXXX, HEV, Immunogenic, Neutralizing, OID-NCHHSTP-DVH, POLYPEPTIDES, VLXXXX, VPXXXX, WBXXXX, WFXXXX, WHXXXX, WIXXXX, WJXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials, ResearchProducts > Antibodies, TherapeuticArea > Cardiology, Application > Occupational Safety and Health, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology

HIV-1 Multi-Clade, Multivalent Recombinant Vaccine Construct

CDC scientists developed immunogenic multi-clade, multivalent (HIV1MCMV) recombinant constructs for use as HIV-1 vaccines. These polypeptides include immunogenic CTL, T- and/or B-cell determinants that are capable of eliciting broad and effective immune responses against diverse subtypes of HIV-1. It is believed that these HIV-1 constructs provide universal...

Published: 7/25/2024 | Inventor(s): Sherry Owen, Renu Lal

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Constructs, DB4AXX, DB4XXX, DBXXXX, DC1XXX, DC5AXX, DC5XXX, DCXXXX, HIV-1, Immunogenic, Methods, Multi-clade, MULTIVALENT, OID-NCHHSTP-DHPSE, Their

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Therapeutics

PSM Peptides as Vaccine Targets Against Methicillin-Resistant Staphylococcus aureus

Available for licensing and commercial development are compositions and methods for the treatment and inhibition of Methicillin-resistant Staphylococcus aureus (MRSA), a dangerous human pathogen. The invention concerns immunogenic peptides that can be used to induce protective immunity against MRSA, including phenol-soluble modulin (PSM) peptides. In...

Published: 7/25/2024 | Inventor(s): Rong Wang, Michael Otto

Keywords(s): Against, ANTIBIOTIC, AUREUS, CA-MRSA, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DXXXXX, fasciitis, Gene, GenePeptides, Immunity, Immunogenic, Methicillin-resistant, MRSA, necrotizing, necrotizing fasciitis, Peptides, PMS, PSM, Staphloccus, STAPHYLOCOCCAL, Staphylococcus, Targets, Vaccine

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease