Search Results - eric+tran

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T Cell Receptors Targeting KRAS Mutants for Cancer Immunotherapy/Adoptive Cell Therapy

Abstract: Mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene are among the most common oncogenic drivers in human cancers, affecting nearly a third of all solid tumors. Point mutations in the KRAS gene most frequently affect amino acid position 12, resulting in the substitution of the native glycine (G) residue for other amino...

Published: 4/8/2024 | Inventor(s): Eric Tran, Yong-Chen Lu, Paul Robbins, Steven Rosenberg, Anna Pasetto, Zhili Zheng

Keywords(s): CANCER, Immunotherapy, Mutated KRAS, Rosenberg, T-cell Receptors

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

T-Cell Therapy Against Patient-Specific Cancer Mutations

Abstract: Human cancers contain genetic mutations that are unique to each patient. Some of the mutated peptides are immunogenic, can be recognized by T cells, and therefore, may serve as therapeutic targets. Scientists at the National Cancer Institute's Surgery Branch developed a method to identify T cells that specifically recognize immunogenic mutations...

Published: 4/8/2024 | Inventor(s): Eric Tran, Yong-Chen Lu, Paul Robbins, Steven Rosenberg

Keywords(s): Cholangiocarcinoma, Immunogenic, Rosenberg, T-cell, Tran

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

T-Cell Therapy Against Patient-Specific Cancer Mutations

Published: 4/8/2024 | Inventor(s): Eric Tran, Paul Robbins, Yong-Chen Lu, Steven Rosenberg

Keywords(s): Cholangiocarcinoma, Immunogenic, T cell, T-cell

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology