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T Cell Receptors Targeting KRAS Mutants for Cancer Immunotherapy/Adoptive Cell Therapy

Abstract: Mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene are among the most common oncogenic drivers in human cancers, affecting nearly a third of all solid tumors. Point mutations in the KRAS gene most frequently affect amino acid position 12, resulting in the substitution of the native glycine (G) residue for other amino...

Published: 4/22/2025 | Inventor(s): Eric Tran, Yong-Chen Lu, Paul Robbins, Steven Rosenberg, Anna Pasetto, Zhili Zheng

Keywords(s): CANCER, Immunotherapy, Mutated KRAS, Rosenberg, T-cell Receptors

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

A Rapid Method of Isolating Neoantigen-specific T Cell Receptor Sequences

Abstract: Tumors can develop unique genetic mutations which are specific to an individual patient. Some of these mutations are immunogenic; giving rise to autologous T cells which are tumor-reactive. Once isolated and sequenced, these neoantigen-specific TCRs can form the basis of effective adoptive cell therapy cancer treatment regimens; however, current...

Published: 4/22/2025 | Inventor(s): Yong-Chen Lu, Zhili Zheng, Peter Fitzgerald, Steven Rosenberg

Keywords(s): CANCER, Immunotherapy, Single Cell, T-cell Receptors, TCR, tumor

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology