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A Rapid Method of Isolating Neoantigen-specific T Cell Receptor Sequences

Abstract: Tumors can develop unique genetic mutations which are specific to an individual patient. Some of these mutations are immunogenic; giving rise to autologous T cells which are tumor-reactive. Once isolated and sequenced, these neoantigen-specific TCRs can form the basis of effective adoptive cell therapy cancer treatment regimens; however, current...

Published: 4/8/2024 | Inventor(s): Yong-Chen Lu, Zhili Zheng, Peter Fitzgerald, Steven Rosenberg

Keywords(s): CANCER, Immunotherapy, Single Cell, T-cell Receptors, TCR, tumor

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology