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Novel HPPK (Bacterial Protein) Inhibitors for Use as Antibacterial Agents

Abstract: Research and development leading to the discovery of novel antibiotics has waned in recent years. At the same time, the emergence and spread of antimicrobial resistance has compounded the global danger to human health from bacterial infections. The bacterial protein 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is a key enzyme...

Published: 4/8/2024 | Inventor(s): Xinhua Ji, Genbin Shi, Gary Shaw

Keywords(s): ANTIBIOTIC, Bacterial Protein, BACTERICIDAL, Biodefense, Broad Spectrum, Folate Biosynthesis, HPPK, Ji, small molecule

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics

PSM Peptides as Vaccine Targets Against Methicillin-Resistant Staphylococcus aureus

Available for licensing and commercial development are compositions and methods for the treatment and inhibition of Methicillin-resistant Staphylococcus aureus (MRSA), a dangerous human pathogen. The invention concerns immunogenic peptides that can be used to induce protective immunity against MRSA, including phenol-soluble modulin (PSM) peptides. In...

Published: 10/28/2024 | Inventor(s): Rong Wang, Michael Otto

Keywords(s): Against, ANTIBIOTIC, AUREUS, CA-MRSA, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DXXXXX, fasciitis, Gene, GenePeptides, Immunity, Immunogenic, Methicillin-resistant, MRSA, necrotizing, necrotizing fasciitis, Peptides, PMS, PSM, Staphloccus, STAPHYLOCOCCAL, Staphylococcus, Targets, Vaccine

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease