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Novel Inactivated Zika Vaccine Candidate Based on Purified Wild-type Zika Virus — for Zika Vaccine and Diagnostic Assay Development

Zika virus (ZIKV) spreads to people primarily through bite by infected Aedes mosquitoes. ZIKV infection during pregnancy can cause stillbirths or affect the fetus by causing serious birth defects, such as microcephaly and other brain defects. Although uncommon, adults with ZIKV can also develop Guillain-Barre syndrome and other neurological disorders....

Published: 4/8/2024 | Inventor(s): Holli Giebler, Windy Baldwin, Claire Kinney, Jill Livengood

Keywords(s): Compositions, Immunogenic, Methods, SAME, vaccines, YBXXXX, YCXXXX, YDXXXX, YXXXXX, Zika

Category(s):

Novel ACRV1/ALK2 Inhibitors and Methods for Inhibiting BMP Signaling for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

This technology includes the identification and use of novel ACRV1/ALK2 inhibitors for the treatment of fibrodysplasia ossificans progressiva (FOP), an autosomal-dominant rare disease that affects one person in every 1-2 million. FOP is characterized by malformation of the great (big) toes during embryonic development and by progressive heterotopic...

Published: 7/25/2024 | Inventor(s): Jian-kang Jiang, Khalida Shamim, Philip Sanderson, Wei Zheng, Xiuli Huang, Gregory Tawa, Asaf Alimardanov, Arthur Lee, Junfeng Huang, Wenwei Huang

Keywords(s): ALK2, BMP, INHIBITING, Inhibitors, Methods, Novel, SIGNALING, VGXXXX, WIXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Endocrinology, Application > Therapeutics, Application > Research Materials

A Group of Compounds that Activate AMP-activated protein kinase (AMPK) that may Treat Niemann-Pick Disease Type C (NPC)

This technology relates to the identification and use of a group of compounds that activate the AMP-activated protein kinase (AMPK) and also effectively reduce lysosomal cholesterol accumulation in patients with Niemann-Pick disease Type C (NPC). Clinical trials are currently underway to determine the efficacy of beta-cyclodextrin in treating patients...

Published: 7/25/2024 | Inventor(s): Zachery Caffall, Joseph Rittiner, Nicole Calakos

Keywords(s): AMPK, C, Compositions, Disease, DISORDERS, Dystonia, Identifying, Methods, MODULATORS, Niemann, Pick, TREATING, treatment, TYPE, VEXXXX, WIXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Neurology, Application > Therapeutics, Application > Research Materials

Plasmids Encoding and Producing Anthrax Toxin Proteins

Plasmid pSJ136-EF-A — A plasmid encoding mutant anthrax toxin proteins such as lethal factor (LF) or edema factor (EF). Anthrax toxin and anthrax toxin fusion proteins may be used as therapeutic agents for cancer. Plasmid PSJ115-LFOS — A plasmid expressing anthrax toxin proteins such as lethal factor (LF) or edema factor (EF) which has the original...

Published: 7/25/2024 | Inventor(s): Pradeep Gupta, Yiu Cheung, Haijing Hu, Mahtab Moayeri, Stephen Leppla

Keywords(s): Anthrax, Improved, Listed LPM Soukas as of 4/15/2015, Methods, PLASMID, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, production, proteins, RM, TOXINS, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Discrete Cross-Reactive Epitopes for Flavivirus Serological Diagnostics and Vaccines

CDC researchers have identified and characterized discrete flavivirus cross-reactive epitopes useful for improving serodiagnosis and vaccination of flaviviruses, such as dengue virus, yellow fever virus, Japanese encephalitis virus, West Nile virus and the tick-borne encephalitis viruses. The flavivirus envelope glycoprotein is one of the primary antigens...

Published: 7/25/2024 | Inventor(s): Wayne Crill, Gwong-Jen Chang

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, CHARACTERIZATION, Cross-Reactive, Envelope, Epitopes, Flavivirus, GLYCOPROTEIN, LOCALIZATION, Methods, OID-NCEZID-DVBD, Their, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WIXXXX, WJXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Application > Occupational Safety and Health, ResearchProducts > Antibodies, Application > Research Materials, Application > Therapeutics, Application > Diagnostics

Compositions for Modification of Genomic DNA and Exogenous Gene Expression

A novel method of targeted insertion of transgenes at CLYBL locus directly in human cells is disclosed. Also, methods and compositions for increasing targeted insertion of a transgene into a specific location within the cell or increasing the frequency of gene modification in a targeted locus are disclosed. Genome modification by precise gene targeting...

Published: 7/30/2024 | Inventor(s): Mahendra Rao, Jizhong Zou

Keywords(s): Cl, Compositions, GB2BXX, GB2CXX, Genome, Harbor, LOCUS, Methods, MODIFICATION, SAFE, Targeted, VEXXXX, WIXXXX, WJXXXX, XEXXXX, YAXXXX, YBL, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Neurology

Compositions and Methods for Improved Lyme Disease Diagnosis

This CDC-developed technology entails novel compositions and methods related to the diagnosis of Lyme disease. Lyme disease, caused by the Borrelia burgdorferi bacterium, is the most common tick-borne infectious disease in the US and Europe. Diagnosis of Lyme disease is particularly challenging as symptoms often appear long after exposure. At present,...

Published: 7/25/2024 | Inventor(s): Theresa Russell, Barbara Johnson

Keywords(s): BACTERIA, BORRELIA BURGDORFERI, BORRELLIA, BURGDORFERI, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA3XXX, DAXXXX, diagnostic, Diagnostic assay, diagnostic in vitro, Disease, DXXXXX, ivd, LYME, Methods, Relating, TICK, TICK-BORNE, TICKS, Vector-borne, Vector-borne diseases, VETERINARY, VJXXXX, VOXXXX, WBXXXX, WCXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, YBXXXX, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Occupational Safety and Health, Application > Consumer Products, TherapeuticArea > Infectious Disease

Silica Exposure Safety: Mini-baghouse Systems and Methods for Controlling Particulate Release from Large Sand Transfer Equipment

CDC/NIOSH scientists have developed an effective point-source control for silica-containing dusts that can be generated from machinery on sites where hydraulic fracturing is occurring. The CDC/NIOSH mini-baghouse retrofit assembly is a bolt-on control designed to contain silica-containing respirable dusts generated during refill operations of sand...

Published: 7/25/2024 | Inventor(s): Michael Breitenstein, John Snawder

Keywords(s): AE1XXX, AE2XXX, AE3XXX, AEXXXX, AGXXXX, apparatus, AXXXXX, Baghouse, CDC Docket Import, CDC Docket Import CDC Prosecuting, CONTROL, CONTROLING, Crystalline, DEVICE, DUST, Dust collector, ENVIRONMENT, ENVIRONMENTAL, environmental health, Equipment, Fracturing, HYDRAULIC, LARGE, Methods, MINE, MINER, Mini, MINING, Movers, MULTIPLE, NIOSH, NIOSH-DSHEFS, Occupational health, PARTICULATE, Release, RESPIRABLE, Respiration, Respirator, Retrofit, SAND, SILICA, SILICOSIS, SYSTEMS, VPXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WMXXXX, XDXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Dental, Application > Consumer Products, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Medical Devices, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health

Mining Safety: Personal Dust Monitor Filters for Accurate, Quantifiable Spectrometric Analysis and Assessment of Worker Exposure Levels

This CDC-developed invention pertains to a novel dust monitor filter that is specially constructed of organic materials for spectrometric analysis, ultimately allowing for detection and accurate quantification of a particular chosen analyte (e.g., crystalline silica/quartz dust that may lead to silicosis). For miners, the risk of lung disease increases...

Published: 7/25/2024 | Inventor(s): Donald Tuchman

Keywords(s): AAXXXX, AC1XXX, AC3XXX, ACXXXX, AE1XXX, AE2XXX, AE3XXX, AE4XXX, AEXXXX, AIRBORNE, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CHARACTERIZING, COAL, DUST, Dust collector, Methods, MINE, MINER, MINING, MONITOR, NIOSH, NIOSH-PRL, PARTICULATES, VPXXXX, WBXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WMXXXX, XDXXXX, XIXXXX, YAXXXX, YBXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Occupational Safety and Health, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, Application > Diagnostics, Application > Consumer Products, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Medical Devices, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease

Air Quality Assurance: A Monitor for Continuous, Simultaneous Analysis of Atmospheric or Aerosolized Particulate Mixtures

This technology pertains to monitors for measuring the mass concentration of ambient particulate matter in an atmosphere containing both larger/coarser (e.g., respirable dust) and smaller/finer (sub-micrometer particles such as diesel particulate matter - DPM) particulate mixtures. The monitoring device can be configured for operation with a controller...

Published: 7/25/2024 | Inventor(s): Jon Volkwein, William Schiffbauer, Charles Litton

Keywords(s): AE1BXX, AE2BXX, AE2XXX, AE3XXX, AEXXXX, ANALYZING, apparatus, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Ionization, Light-scattering, Methods, NIOSH-PRL, PARTICLES, SENSORS, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WMXXXX, XDXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Medical Devices, Application > Occupational Safety and Health, Application > Non-Medical Devices, Application > Consumer Products

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