HOME
SEARCH
RSS FEED
SUBSCRIBE
A Group of Compounds that Activate AMP-activated protein kinase (AMPK) that may Treat Niemann-Pick Disease Type C (NPC)
Case ID:
TAB-3590
Web Published:
12/6/2022
Description:
This technology relates to the identification and use of a group of compounds that activate the AMP-activated protein kinase (AMPK) and also effectively reduce lysosomal cholesterol accumulation in patients with Niemann-Pick disease Type C (NPC). Clinical trials are currently underway to determine the efficacy of beta-cyclodextrin in treating patients with NPC. A potential mechanism has been proposed indicating that beta-cyclodextrin activated AMP-activated protein kinase, leading to restoration of autophagy in cells from NPC patients. A computer modeling was used to identify the group of compounds that bind and activate AMPK. Eight of the compounds were found to effectively reduce cholesterol accumulation in lysosomes of cells from NPC patients.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Patent Status
Direct Link:
https://nih.technologypublisher.com/tech/A_Group_of_Compounds_that_Activate_A MP-activated_protein_kinase_(AMPK)_that_may_Treat_Niemann-Pick_Disease_Type_C_(NPC)
Category(s):
Neurology
Therapeutics
Research Materials
Bookmark this page
Download as PDF
For Information, Contact:
Suryanarayana Vepa
Technology Licensing Specialist
NIH Technology Transfer
301-827-7181
sury.vepa@nih.gov
Inventors:
Zachery Caffall
Joseph Rittiner
Nicole Calakos
Keywords:
AMPK
C
Compositions
Disease
DISORDERS
Dystonia
Identifying
Methods
MODULATORS
Niemann
Pick
TREATING
treatment
TYPE
VEXXXX
WIXXXX
WKXXXX
XEXXXX
Home
|
Search
|
RSS
|
Subscribe
© 2024. All Rights Reserved. Powered by
Inteum