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Novel Inactivated Zika Vaccine Candidate Based on Purified Wild-type Zika Virus — for Zika Vaccine and Diagnostic Assay Development

Zika virus (ZIKV) spreads to people primarily through bite by infected Aedes mosquitoes. ZIKV infection during pregnancy can cause stillbirths or affect the fetus by causing serious birth defects, such as microcephaly and other brain defects. Although uncommon, adults with ZIKV can also develop Guillain-Barre syndrome and other neurological disorders....

Published: 4/8/2024 | Inventor(s): Holli Giebler, Windy Baldwin, Claire Kinney, Jill Livengood

Keywords(s): Compositions, Immunogenic, Methods, SAME, vaccines, YBXXXX, YCXXXX, YDXXXX, YXXXXX, Zika

Category(s):

A Group of Compounds that Activate AMP-activated protein kinase (AMPK) that may Treat Niemann-Pick Disease Type C (NPC)

This technology relates to the identification and use of a group of compounds that activate the AMP-activated protein kinase (AMPK) and also effectively reduce lysosomal cholesterol accumulation in patients with Niemann-Pick disease Type C (NPC). Clinical trials are currently underway to determine the efficacy of beta-cyclodextrin in treating patients...

Published: 7/25/2024 | Inventor(s): Zachery Caffall, Joseph Rittiner, Nicole Calakos

Keywords(s): AMPK, C, Compositions, Disease, DISORDERS, Dystonia, Identifying, Methods, MODULATORS, Niemann, Pick, TREATING, treatment, TYPE, VEXXXX, WIXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Neurology, Application > Therapeutics, Application > Research Materials

A Novel High-Throughput Assay for Identifying Zike Virus NS2B-NS3 Protease Inhibitors

This invention includes a novel high-throughput assay to identify orthosteric inhibitors blocking the Zika virus NS2B-NS3 protease. Pathogenic flaviviruses, including Zika, require the NS2B-NS3 protease for viral replication. There is currently an unmet need for specific antiviral therapeutics against the Zika virus. Preliminary screening using the...

Published: 7/25/2024 | Inventor(s): Menghang Xia, Ruili Huang, Laura Kramer, Zhong Li, Hongmin Li

Keywords(s): Activity, Antiflaviviral, Compositions, PHARMACEUTICAL, VLXXXX, WIXXXX, WKXXXX, XHXXXX

Category(s): TherapeuticArea > Infectious Disease, Application > Therapeutics, ResearchProducts > Research Equipment, Application > Research Materials

Compositions for Modification of Genomic DNA and Exogenous Gene Expression

A novel method of targeted insertion of transgenes at CLYBL locus directly in human cells is disclosed. Also, methods and compositions for increasing targeted insertion of a transgene into a specific location within the cell or increasing the frequency of gene modification in a targeted locus are disclosed. Genome modification by precise gene targeting...

Published: 7/30/2024 | Inventor(s): Mahendra Rao, Jizhong Zou

Keywords(s): Cl, Compositions, GB2BXX, GB2CXX, Genome, Harbor, LOCUS, Methods, MODIFICATION, SAFE, Targeted, VEXXXX, WIXXXX, WJXXXX, XEXXXX, YAXXXX, YBL, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Neurology

Compositions and Methods for Improved Lyme Disease Diagnosis

This CDC-developed technology entails novel compositions and methods related to the diagnosis of Lyme disease. Lyme disease, caused by the Borrelia burgdorferi bacterium, is the most common tick-borne infectious disease in the US and Europe. Diagnosis of Lyme disease is particularly challenging as symptoms often appear long after exposure. At present,...

Published: 7/25/2024 | Inventor(s): Theresa Russell, Barbara Johnson

Keywords(s): BACTERIA, BORRELIA BURGDORFERI, BORRELLIA, BURGDORFERI, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA3XXX, DAXXXX, diagnostic, Diagnostic assay, diagnostic in vitro, Disease, DXXXXX, ivd, LYME, Methods, Relating, TICK, TICK-BORNE, TICKS, Vector-borne, Vector-borne diseases, VETERINARY, VJXXXX, VOXXXX, WBXXXX, WCXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, YBXXXX, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Occupational Safety and Health, Application > Consumer Products, TherapeuticArea > Infectious Disease

Recombinant Polypeptides for Clinical Detection of Taenia solium and Diagnosis of Cysticercosis

CDC scientists have developed synthetic/recombinant polypeptides that can be used for the creation of inexpensive, high-quality cysticercosis diagnostic assays. Taenia solium is a species of pathogenic tapeworm. Intestinal infection with this parasite is referred to as taeniasis and it is acquired by ingestion of T. solium cysticerci found in raw...

Published: 7/25/2024 | Inventor(s): Ryan Greene, Patricia Wilkins, Kathy Hancock, Victor Tsang

Keywords(s): ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, Cloned, Compositions, DA2XXX, DAXXXX, DETECTING, diagnostic, DXXXXX, I-031-98, I-031-99, Larval, Methods, SOLIUM, TAENIA, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WBXXXX, WFXXXX, WJXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Oncology

Methods for the Simultaneous Detection of Multiple Analytes

CDC researchers have developed a method of simultaneously detecting and distinguishing multiple antigens within a biological sample. Epidemiological and vaccine studies require species serotype identification. Current methods of serotyping are labor intensive and can easily give subjective, errant results. This technology utilizes serotype specific...

Published: 7/25/2024 | Inventor(s): George Carlone, Joseph Martinez

Keywords(s): AA5XXX, AAXXXX, ANALYTES, AXXXXX, Bead, Beads, CA1BXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA1XXX, DA2XXX, DA3XXX, DA4AXX, DA4BXX, DA4XXX, DA5XXX, DAXXXX, Detection, flow cytometer, flow cytometry, IAXXXX, IMMUNOASSAY, Methods, MULTIPLE, SIMULTANEOUS, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Consumer Products, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, ResearchProducts > Antibodies, Application > Occupational Safety and Health

Real-time PCR Assays for Human Bocavirus Detection and Diagnosis

CDC researchers have developed a real-time PCR assay for the detection and viral-load quantitative estimations of human bocavirus (HBoV) from clinical specimens. At present, there have been few reports on the epidemiology, geographic distribution or clinical features of HBoV infection. Additionally, symptoms affiliated with bocavirus infections overlap...

Published: 4/8/2024 | Inventor(s): Teresa Peret, Dean Erdman

Keywords(s): Bocavirus, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA4XXX, DAXXXX, DXXXXX, Human, NAT, Nucleic, nucleic acid, NUCLEIC ACID DETECTION, OID-NCIRD-DVD, Processes, QUANTITATIVE, real time, Realtime, REAL-TIME, Relating, respiratory, Respiratory Diseases, respiratory INFECTION, viral, VIRAL DIAGNOSTIC, VLXXXX, VPXXXX, WBXXXX, WFXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Dental, Application > Diagnostics, Application > Therapeutics, Application > Occupational Safety and Health, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Infectious Disease, Application > Consumer Products, TherapeuticArea > Oncology

Real-time RT-PCR Assay for the Detection of Rift Valley Fever Virus in Humans and Livestock

A quantitative RT-PCR-based assay has been developed to rapidly detect all known strains of Rift Valley fever virus (RVFV). RVFV infections occur in both humans and livestock animals resulting in significant mortality and economic loss. Upon outbreak, RVFV has been known to cause devastating loss among livestock (primarily sheep and cattle) with outbreaks...

Published: 7/25/2024 | Inventor(s): Stuart Nichol, Brian Bird

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DDXXXX, Diagnosis, DXXXXX, FEVER, Kits, Methods, Pan-Rift, QUANTITATIVE, REAL-TIME, RT-PCR, Valley, VBXXXX, virus, VLXXXX, VOXXXX, WAXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Occupational Safety and Health, Application > Research Materials, Application > Diagnostics, Application > Vaccines, Application > Therapeutics

Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling System

This invention provides a rapid, sensitive and specific diagnostic tool for the detection of pathogenic fungi and subsequent species-specific discrimination. CDC scientists have developed nucleic acid probes to identify the six most medically important Candida species and endemic mycoses, and to differentiate them from other medically important fungi...

Published: 7/25/2024 | Inventor(s): Sanchita Das, Teresa Brown, Brian Holloway, Christine Morrison

Keywords(s): Bead, Beads, CANDIDA, CDC Docket Import, CDC Docket Import CDC Prosecuting, Clinical, Clinical SAMPLE, Compositions, DA1XXX, DAXXXX, Detection, Diagnose, Diagnosis, diagnostic, Diagnostic assay, Discriminate, discrimination, DXXXXX, FUNGAL, FUNGI, fungus, Methods, microarray, Nucleic, nucleic acid, OID-NCEZID-DFWED, PATHOGEN, PATHOGENIC, Probe, Species, VKXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XEXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Occupational Safety and Health, Application > Diagnostics, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment

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