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Nucleic Acid Primers and Probes for Detecting Ebola Virus (species Zaire ebolavirus)

The 2014-2016 Ebola Virus Disease (EVD) outbreak in West Africa was the largest in history, causing more than 28,000 suspected, probable, and confirmed infections and more than 11,000 deaths across nine countries. CDC scientists designed nucleic acid primers and probes which can be used in a sensitive test for detecting all known strains of Ebola virus...

Published: 7/25/2024 | Inventor(s): Tara Sealy, Ute Stroeher, Stuart Nichol, Jonathan Towner

Keywords(s): 7, Acid, antibodies, ANTIGENS, assay, DETECTING, Detection, Ebola, Ebolavirus, ELISA, Enzyme, Identification, immunosorbent, LINKED, Listed LPM Kirby as of 4/15/2015, Mab, monoclonal, Mouse, NCEZID, NCEZID-DHCPP, Nucleic, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PRIMERS, Probes, Species, Used, virus, Viruses, Zaire

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling System

This invention provides a rapid, sensitive and specific diagnostic tool for the detection of pathogenic fungi and subsequent species-specific discrimination. CDC scientists have developed nucleic acid probes to identify the six most medically important Candida species and endemic mycoses, and to differentiate them from other medically important fungi...

Published: 7/25/2024 | Inventor(s): Sanchita Das, Teresa Brown, Brian Holloway, Christine Morrison

Keywords(s): Bead, Beads, CANDIDA, CDC Docket Import, CDC Docket Import CDC Prosecuting, Clinical, Clinical SAMPLE, Compositions, DA1XXX, DAXXXX, Detection, Diagnose, Diagnosis, diagnostic, Diagnostic assay, Discriminate, discrimination, DXXXXX, FUNGAL, FUNGI, fungus, Methods, microarray, Nucleic, nucleic acid, OID-NCEZID-DFWED, PATHOGEN, PATHOGENIC, Probe, Species, VKXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XEXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Occupational Safety and Health, Application > Diagnostics, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment

Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungi

This invention pertains to the development of oligonucleotides for the rapid nucleic acid-based identification of the Candida fungi species C. haemulonii, C. kefyr, C. lambica, C. lusitaniae, C. norvegensis, C. norvegica, C. rugosa, C. utilis, C. viswanathii, C. zeylanoides, C. dubliniensis, and C. pelliculosa within biological samples. This identification...

Published: 7/25/2024 | Inventor(s): Cheryl Elie, Christine Morrison, Errol Reiss, Timonthy Lott

Keywords(s): Acid, CANDIDA, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, DXXXXX, Nucleic, OID-NCEZID-DFWED, Probes, Species, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, TherapeuticArea > Dental, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology

Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samples

This invention relates to assays for the detection and species-specific identification of Aspergillus fungi. Accurate clinical diagnosis of Aspergillus species has become increasingly important as certain species, such as A. terreus and A. fumigatus, are resistant to specific commonly employed antifungal compounds. Most contemporary fungal diagnostic...

Published: 7/25/2024 | Inventor(s): Hans Hinrikson, Christine Morrison

Keywords(s): Aspergillus, CDC Docket Import, CDC Docket Import CDC Prosecuting, DAXXXX, DXXXXX, Identification, Molecular, OID-NCEZID-DFWED, Species, VKXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XCXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Occupational Safety and Health, ResearchProducts > Research Equipment, Application > Research Materials, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, TherapeuticArea > Dental, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease

Species-specific Nucleic Acid Detection Assay for Fungi

This invention pertains to nucleic acid-based assays for the detection of Aspergillus and other filamentous fungi. Assays cover the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizomucor, Absidia, Cunninghamella, Pseudallescheria or Sporthrix in a subject. This can reduce identification time from...

Published: 7/25/2024 | Inventor(s): Errol Reiss, Lilianna Aidorevich, Jong Soo Choi, Christine Morrison

Keywords(s): Acids, Aspergillus, CANDIDA, CANDIDA ALBICANS, candidiasis, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, Detection, diagnostic, discrimination, DXXXXX, FUNGAL, FUNGI, fungus, I-016-96, I-016-96/0, Mold, Molds, Nucleic, nucleic acid, NUCLEIC ACID DETECTION, OID-NCEZID-DFWED, PCR, PCR ASSAY, PRIMERS, Species, VKXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology

Real-time PCR Assays for Selective Detection and Differentiation of B. pertussis, B. parapertussis and B. homesii

CDC researchers developed a real-time PCR assay targeting insertion sequence (IS481) and pertussis toxin subunit 1 (ptxS1) of Bordetella pertussis. This real-time nucleic acid assay offers rapid, sensitive, and quantitative results. The employed primers have been validated through extensive diagnostic testing of 41 Bordetella and 64 non-Bordetella...

Published: 7/25/2024 | Inventor(s): Kansas Sparks, Maria-Lucia Tondella, Kathleen Tatti

Keywords(s): BORDETELLA, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, Detection, DXXXXX, SELECTIVE, Species

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics

Signatures of Genetic Control in Digestive and Liver Disorders

Our technology describes unique genetic signatures in patients with digestive diseases and liver disorders. Using comprehensive analysis of 735 microRNAs and 19,000 mRNAs, we have identified a unique set of microRNAs and/or mRNAs which predict disease phenotypes in patients with digestive and liver disorders. The identification of such point-of- care...

Published: 7/25/2024 | Inventor(s): Ralph Peace, Nicolaas Fourie, Sarah Abey, Wendy Henderson

Keywords(s): Acid, Altered, CAXXXX, CXXXXX, Digestive, DISORDERS, Expressions, IA3XXX, IAXXXX, IB3XXX, IBXXXX, Identification, IXXXXX, Listed LPM Vepa as of 4/15/2015, liver, MESSENGER, MICRO, miRNA, PHENOTYPE, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Ribonucleic, RNA, Species, THERAPY

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology