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Reducing Bloodstream Neutrophils as a Treatment for Lung Infection and Inflammation

During lung infection, bloodstream neutrophils (PMNs) responding to infection travel to the airspace lumen. Although successful arrival of microbicidal PMNs to the airspace is essential for host defense against inhaled pathogens, excessive accumulation of PMNs in the lung contributes to the pathogenesis of several prevalent lung disorders, including...

Published: 10/28/2024 | Inventor(s): Carmen Williams, Wan-Chi Lin, Michael Fessler

Keywords(s): 2, BARRIER, DA1XXX, DA3XXX, DA4XXX, DAXXXX, DBXXXX, During, DXXXXX, Epithelial, Infection, Inflammation, INTEGRITY, LUNG, MEMBRANE, PROTECT, Protein, respiratory, Targeting, VJXXXX, VKXXXX, VLXXXX, VPXXXX, WBXXXX, WJXXXX, WKXXXX, XAXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, ResearchProducts > Antibodies, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Dental, TherapeuticArea > Immunology, TherapeuticArea > Oncology

Rapid Method for the Detection of Antigen-Specific Antibodies in Any Species

Currently available identification methods for antigen-specific antibodies require live pathogens, antisera (that are only available for a limited number of species), and species-specific secondary antibodies (also a limited resource). Thus, detection or surveillance of pathogens in wild avian species or zoo animals, for example, is complex and cumbersome. Researchers...

Published: 4/24/2025 | Inventor(s): Alison Basile

Keywords(s): antibodies, ANTIGEN-SPECIFIC, Biological, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DA3XXX, DA4XXX, DAXXXX, DDXXXX, Detection, Listed LPM Houze as of 4/15/2015, Method, OID-NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SAMPLES, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WBXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Research Equipment, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials

Small Molecule Imaging of Fungi by Positron Emission Tomography Scanning

This technology relates to the field of radioactive, isotopically-labeled calcofluor derivatives and uses of such compounds to detect a broad spectrum of filamentous fungi including pathogenic species such as Aspergillus and Mucorales, by diagnostic imaging methods such as positron emission tomography (PET) scanning. Aspergillosis and other filamentous...

Published: 10/28/2024 | Inventor(s): Dale Kiesewetter, John Panepinto, Jin Qiu, Peter Williamson

Keywords(s): DA1XXX, FUNGI, IMAGING, Listed LPM Fenn as of 4/15/2015, MOLECULE, PET, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SCANNING, Small, VKXXXX, WBXXXX, XFXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Medical Devices, Application > Software / Apps, Application > Diagnostics, Application > Non-Medical Devices

Methods for the Simultaneous Detection of Multiple Analytes

CDC researchers have developed a method of simultaneously detecting and distinguishing multiple antigens within a biological sample. Epidemiological and vaccine studies require species serotype identification. Current methods of serotyping are labor intensive and can easily give subjective, errant results. This technology utilizes serotype specific...

Published: 10/28/2024 | Inventor(s): George Carlone, Joseph Martinez

Keywords(s): AA5XXX, AAXXXX, ANALYTES, AXXXXX, Bead, Beads, CA1BXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA1XXX, DA2XXX, DA3XXX, DA4AXX, DA4BXX, DA4XXX, DA5XXX, DAXXXX, Detection, flow cytometer, flow cytometry, IAXXXX, IMMUNOASSAY, Methods, MULTIPLE, SIMULTANEOUS, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Consumer Products, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, ResearchProducts > Antibodies, Application > Occupational Safety and Health

Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling System

This invention provides a rapid, sensitive and specific diagnostic tool for the detection of pathogenic fungi and subsequent species-specific discrimination. CDC scientists have developed nucleic acid probes to identify the six most medically important Candida species and endemic mycoses, and to differentiate them from other medically important fungi...

Published: 4/24/2025 | Inventor(s): Sanchita Das, Teresa Brown, Brian Holloway, Christine Morrison

Keywords(s): Bead, Beads, CANDIDA, CDC Docket Import, CDC Docket Import CDC Prosecuting, Clinical, Clinical SAMPLE, Compositions, DA1XXX, DAXXXX, Detection, Diagnose, Diagnosis, diagnostic, Diagnostic assay, Discriminate, discrimination, DXXXXX, FUNGAL, FUNGI, fungus, Methods, microarray, Nucleic, nucleic acid, OID-NCEZID-DFWED, PATHOGEN, PATHOGENIC, Probe, Species, VKXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XEXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Occupational Safety and Health, Application > Diagnostics, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment

Nucleic Acid-based Compositions and Methods for the Species-Specific Detection of Pathogenic Candida Fungi

This invention pertains to the development of oligonucleotides for the rapid nucleic acid-based identification of the Candida fungi species C. haemulonii, C. kefyr, C. lambica, C. lusitaniae, C. norvegensis, C. norvegica, C. rugosa, C. utilis, C. viswanathii, C. zeylanoides, C. dubliniensis, and C. pelliculosa within biological samples. This identification...

Published: 4/24/2025 | Inventor(s): Cheryl Elie, Christine Morrison, Errol Reiss, Timonthy Lott

Keywords(s): Acid, CANDIDA, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, DXXXXX, Nucleic, OID-NCEZID-DFWED, Probes, Species, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, TherapeuticArea > Dental, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology

Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Species

This invention pertains to the development of oligonucleotides for the rapid nucleic acid-based identification of Candida or Aspergillus fungi species in biological samples. This identification is accomplished by the targeting the internally transcribed spacer-2 (ITS2) region that are unique to various Candida species. The assay is sensitive, specific...

Published: 4/24/2025 | Inventor(s): Errol Reiss, Brian Holloway, Jong Shin, Christine Morrison

Keywords(s): AIDS, Aspergilli, Aspergillus, assay, CANDIDA, CANDIDA ALBICANS, candidiasis, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA1XXX, DAXXXX, Detection, diagnostic, DXXXXX, FUNGAL, FUNGI, FUNGI COMPONENTS, fungus, HIV, Immuno-comprimised, IMMUNOCOMPROMISED, Methods, Spp, thrush, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, Application > Occupational Safety and Health, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology

Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples

This invention relates to detecting Histoplasma capsulatum by PCR using oligonucleotide probes specific for the fungus. Histoplasmosis is a mycotic infection of varying severity, usually localized in the lungs. Caused by H. capsulatum, infections are usually symptomatic but can develop into chronic disease, especially in immunocompromised individuals. Test...

Published: 4/18/2025 | Inventor(s): Thomas Reid, Millie Schafer

Keywords(s): AA5XXX, AAXXXX, AIDS, assay, Avian, AXXXXX, CAPSULATUM, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, Detection, diagnostic, DXXXXX, FUNGAL, FUNGI, fungus, HISTOPLASMA, Histoplasmosis, HIV, Method, NESTED, NIOSH-DART, Nucleic, nucleic acid, NUCLEIC ACID DETECTION, PATHOGEN, PATHOGENIC, PATHOGENS, PCR, PCR ASSAY, RAPID, SENSITIVE, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, Application > Therapeutics

Species-specific Nucleic Acid Detection Assay for Fungi

This invention pertains to nucleic acid-based assays for the detection of Aspergillus and other filamentous fungi. Assays cover the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizomucor, Absidia, Cunninghamella, Pseudallescheria or Sporthrix in a subject. This can reduce identification time from...

Published: 4/24/2025 | Inventor(s): Errol Reiss, Lilianna Aidorevich, Jong Soo Choi, Christine Morrison

Keywords(s): Acids, Aspergillus, CANDIDA, CANDIDA ALBICANS, candidiasis, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, Detection, diagnostic, discrimination, DXXXXX, FUNGAL, FUNGI, fungus, I-016-96, I-016-96/0, Mold, Molds, Nucleic, nucleic acid, NUCLEIC ACID DETECTION, OID-NCEZID-DFWED, PCR, PCR ASSAY, PRIMERS, Species, VKXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology

Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis

CDC researchers developed a simple target-specific isothermal nucleic acid amplification technique, termed Genome Exponential Amplification Reaction (GEAR). The method employs a set of four primers (two inner and two outer). The outer primer pair targets three specific nucleic acid sequences at a constant 60°C, while the inner pair of primers accelerates...

Published: 4/24/2025 | Inventor(s): Prithiviraj Jothikumar, Vincent Hill, Jothikumar Narayanan

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC4XXX, AC5XXX, Acids, ACXXXX, amplification, AMPLIFYING, AXXXXX, DA1XXX, DA2XXX, DA3XXX, DA4XXX, DA5XXX, DAXXXX, DXXXXX, Exponential, Gear, Genome, Isothermal, Methods, Nucleic, REACTION, REAGENTS, UBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics, TherapeuticArea > Rare/Neglected Diseases

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