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High Efficacy Vaccine and Microbicide Combination For Use Against HIV

Abstract: Human immunodeficiency virus (HIV) remains a major global health challenge despite the advancement made in development of effective antiretrovirals (ARVs). ARVs are effective at limiting replication and spread of the virus, and progression to acquired immuno-deficiency syndrome (AIDS). However, ARVs often lead to emergence of drug-resistant...

Published: 4/22/2025 | Inventor(s): Genoveffa Franchini, Marjorie Robert-Guroff, Daniel Appella, Sabrina Helmold Hait, Mohammed Rahman, Massimiliano Bissa, Ettore Appella, Lisa Marie Jenkins, Isabela Silva De Castro

Keywords(s): Acquired Immuno-Deficiency Syndrome, ADCC, AIDS, Antibody-dependent Cellular Cytotoxicity, Efferocytosis, Envelope Glycoprotein 120, Envelope Variable Region, Franchini, gp120, HIV, Human Immunodeficiency Virus, Microbicide, SAMT-247, V1, Vaccine

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Application > Vaccines

Anti-Viral Compounds that Inhibit HIV Activity

Abstract: Several novel tropolone derivatives have been identified that inhibit HIV-1 RNase H function and have potential for anti-viral activity due to reduced cellular toxicity. Inhibiting RNase H function is a potential treatment for many viral infections, since RNase H function is essential for viral replication for many pathogenic retroviruses...

Published: 4/22/2025 | Inventor(s): John Beutler, Jiankang Jiang, Suhman Chung, Craig Thomas, Stuart LeGrice, Jennifer Wilson

Keywords(s): AIDS, HIV, ribonuclease H, RNase H, tropolone derivative, viral replication

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease

Immunogens for Use in a High Efficacy HIV Vaccine

Abstract: Human immunodeficiency virus (HIV) infections remain a pandemic, most prevalent in Africa and the Americas. Anti-retroviral treatments have been effective in preventing spread of the virus and active outbreaks of acquired immune deficiency syndrome (AIDS). However, the development and deployment of an effective vaccine would provide long-lasting...

Published: 4/22/2025 | Inventor(s): Genoveffa Franchini, Timothy Cardozo, Isabela Silva De Castro, Giacomo Gorini, Massimiliano Bissa, Manuel Becerra-Flores

Keywords(s): AIDS, Franchini, GLYCOPROTEIN, gp120, HIV, Human Immunodeficiency Virus, V1, V2, Vaccine, Variable Envelope Region

Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines

Real-Time PCR Assay for HIV-1 Subtype Diagnosis and Global Surveillance of Drug Resistance

CDC researchers have developed a patented set of RT-PCR and sequencing primers based on HIV-1 group M sequences. Evaluation of the primers using samples collected around the world demonstrated broad detection capacity for multiple HIV-1 group subtypes and predominant circulating recombinant forms. Commercially available HIV-1 drug resistance (HIVDR)...

Published: 5/9/2025 | Inventor(s): Joshua Devos, Nicholas Wagar, Zhiyong Zhou, Chunfu Yang

Keywords(s): AIDS, assay, blood-borne, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DGHA, DA4AXX, DA4XXX, DAXXXX, DEVELOPING, Diagnosis, diagnostic, DRUG, drug resistance, drug resistant, DXXXXX, EMERGING, EPIDEMIOLOGIC, Genotype, Genotyping, Global, HIV, HIV-1, Listed LPM Houze as of 4/15/2015, PCR, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resistance, RESISTANT, RT-PCR, Surveillance, therapeutic, tropical, viral, virus

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics

On-site in vitro Diagnostic: Real-time Loop-Mediated Isothermal Amplification Detection of HIV-2 Groups A and B

This CDC-developed technology entails a nucleic acid-based HIV-2 in vitro diagnostic assay that is well-suited for use in mobile testing units/vehicles or resource-limited settings, for example, many areas of West Africa. Because HIV-2 requires unique treatment regimens, accurate, early diagnosis is crucial for effective care and directing treatment....

Published: 5/9/2025 | Inventor(s): Sherry Owen, Donna Rudolph, Timothy Granade, Ae Saekhou Youngpairoj, Chou-Pong Pau, Kelly Curtis, Philip Niedzwiedz

Keywords(s): AIDS, amplification, B, DA4AXX, DA4XXX, DAXXXX, Detection, diagnostic, Diagnostic assay, diagnostic in vitro, Diagnostic System, DXXXXX, Field-usable, GCXXXX, Groups, HIV-2, Isothermal, LAMP, Loop-Mediated, LOW INPUT, OID-NCHHSTP-DHPSE, Reverse-Transcription, RT-LAMP, VLXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XEXXXX, YBXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease

Multivalent, Multiple-Antigenic-Peptides for Serological Detection of HIV-1 Groups -M, -N, -O, and HIV-2

This CDC-developed invention pertains to multivalent antigenic peptides (MAPs) that can be used in a variety of HIV/AIDS diagnostics. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is subdivided into groups M, N, and O, while HIV-2 is subdivided into subtypes A and B. Within HIV -1 group M, several different subtypes and numerous forms of recombinant...

Published: 5/9/2025 | Inventor(s): Chou-Pong Pau

Keywords(s): 0, AAXXXX, AIDS, antibodies, ANTIGEN, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4XXX, DAXXXX, Detection, DEVELOPING, DXXXXX, GROUP, HIV-1, HIV-2., LATERAL, M, MAPS, Multiple-antigenic-peptides, MULTIVALENT, N, RESEARCH MATERIAL, virus, VLXXXX, WBXXXX, WFXXXX, WIXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Occupational Safety and Health, Application > Therapeutics, Application > Consumer Products

Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Species

This invention pertains to the development of oligonucleotides for the rapid nucleic acid-based identification of Candida or Aspergillus fungi species in biological samples. This identification is accomplished by the targeting the internally transcribed spacer-2 (ITS2) region that are unique to various Candida species. The assay is sensitive, specific...

Published: 4/24/2025 | Inventor(s): Errol Reiss, Brian Holloway, Jong Shin, Christine Morrison

Keywords(s): AIDS, Aspergilli, Aspergillus, assay, CANDIDA, CANDIDA ALBICANS, candidiasis, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA1XXX, DAXXXX, Detection, diagnostic, DXXXXX, FUNGAL, FUNGI, FUNGI COMPONENTS, fungus, HIV, Immuno-comprimised, IMMUNOCOMPROMISED, Methods, Spp, thrush, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, Application > Occupational Safety and Health, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology

Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples

This invention relates to detecting Histoplasma capsulatum by PCR using oligonucleotide probes specific for the fungus. Histoplasmosis is a mycotic infection of varying severity, usually localized in the lungs. Caused by H. capsulatum, infections are usually symptomatic but can develop into chronic disease, especially in immunocompromised individuals. Test...

Published: 4/18/2025 | Inventor(s): Thomas Reid, Millie Schafer

Keywords(s): AA5XXX, AAXXXX, AIDS, assay, Avian, AXXXXX, CAPSULATUM, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, Detection, diagnostic, DXXXXX, FUNGAL, FUNGI, fungus, HISTOPLASMA, Histoplasmosis, HIV, Method, NESTED, NIOSH-DART, Nucleic, nucleic acid, NUCLEIC ACID DETECTION, PATHOGEN, PATHOGENIC, PATHOGENS, PCR, PCR ASSAY, RAPID, SENSITIVE, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX, Zoo, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, Application > Therapeutics

Simple and Rapid Assay to Detect Acute Subtype B and Group M HIV-1 Infections

Within recent years, point-of-care (POC) testing has allowed for many individuals to be screened for and provided with HIV test results. It is critical to be able to accurately detect acute HIV infections as this is a stage where the risk of transmission is great. Additionally, early HIV detection could lead to less high-risk behavior, thereby reducing...

Published: 5/9/2025 | Inventor(s): Sherry Owen, Donna Rudolph, Kelly Curtis, Philip Niedzwiedz

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC3XXX, AC4XXX, ACXXXX, AIDS, amplification, AXXXXX, B, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA4AXX, DA4XXX, DAXXXX, Detection, diagnostic, DXXXXX, Field, Field-diagnostic, Field-usable, GROUP, HIV, HIV-1, HIV-2, IN-SITU, Isothermal, LAMP, LIMITED-RESOURCE, Listed LPM Houze as of 4/15/2015, Loop-Mediated, LOW INPUT, M, Methods, NCHHSTP, OID-NCHHSTP-DHPSE, On-demand, PCR, PCR ALTERNATIVE, Portable, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RAPID, Reverse-Transcription, RT-LAMP, Subtype, viral, VIRAL DIAGNOSTIC, virus, VLXXXX, WBXXXX, WIXXXX, XCXXXX, XEXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment

CC Chemokine Receptor 5 DNA, New Animal Models and Therapeutic Agents for HIV Infection

Chemokine receptors are expressed by many cells, including lymphoid cells, and function to mediate cell trafficking and localization. CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor (GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes, macrophages, and immature dendritic cells....

Published: 5/12/2025 | Inventor(s): Christopher Broder, Philip Murphy, Ghalib Alkhatib, Edward Berger, Yu Feng, Paul Kennedy, Christophe Combadiere

Keywords(s): 5, Agents, AIDS, also designated as CKR5, ANIMAL, antiretroviral, ANTIVIRAL, cc, CC-CKR5 chemokine receptor, CCR5 and CMKBR5, Chemokine, DB4AXX, DB4XXX, DBXXXX, DDXXXX, DNA, DXXXXX, HIV, Hyper IgM syndrome, Immunodeficiency 2, Immunodeficiency 4, Immunodeficiency-3, Infection, MIP-1a & MIP-1b, Models, Patent Category - Biotechnology, Patent Category - Contested Proceedings, RECEPTOR, receptor for RANTES, Severe combined immunodeficiency, x-linked, therapeutic, Wiskott Aldrich syndrome

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics