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Title
ID
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Oxy
n
itidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer
Summary: The
N
ational Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...
Published: 9/18/2024
|
Inventor(s):
Yves Pommier
,
Li
n
-kun An
,
Keli Agama
,
Evge
n
y Kiselev
,
Azhar Ravji
Keywords(s):
Be
n
zophenanthridine Derivatives
,
Be
n
zophenanthridinone
,
Camptotheci
n
,
Dihydrobe
n
zophenanthridine
,
IRI
N
OTECAN
,
Oxy
n
itidine
,
Pommier
,
Tdp1
,
TOP1
,
Topoisomerase 1B
,
Topoteca
n
,
Tyrosyl-D
N
A Phosphodiesterase 1
Category(s):
Collaboratio
n
Sought > Licensing
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > O
n
cology
,
Applicatio
n
> Therapeutics
Si
n
gle Source-Detector Separation Approach to Calculate Tissue Oxygen Saturation
Summary: The
N
ational Institute of Child Health and Human Development (NICHD) seeks partners and/or licensees to further develop and commercialize the miniaturized tissue oximeter for implementing the single source-detector separation algorithm in existing devices/systems to collect tissue oxygen saturation. Description of Technology: Tissue oxygen...
Published: 9/18/2024
|
Inventor(s):
Thie
n
Nguyen
,
Amir Ga
n
djbakhche
,
Soo
n
gho Park
,
Bria
n
Hill
Keywords(s):
Category(s):
Applicatio
n
> Medical Devices
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > Respiratory
,
TherapeuticArea >
N
eurology
,
TherapeuticArea > I
n
fectious Disease
Methods of Detecti
n
g Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies
Summary: The
N
ational Cancer Institute (NCI) seeks co-development partners and/or licensees for a liquid biopsy diagnostic assay capable of detecting loss of heterozygosity (LOH) and somatic mutations in genes important for antigen processing and presentation and interferon-γ response pathways. Description of Technology: Immunotherapy is...
Published: 9/13/2024
|
Inventor(s):
Scott
N
orberg
,
A
n
drew Sinkoe
,
Xiaoli
n
Wu
,
James Gulley
Keywords(s):
Category(s):
Applicatio
n
> Diagnostics
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > O
n
cology
,
TherapeuticArea > Immu
n
ology
Improved Methods For Cryopreservatio
n
Of Cells, Tissues, And Organs
Summary: The
N
ational Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 9/9/2024
|
Inventor(s):
Ji
n
gxing Ou
,
Kiyoharu Miyagishima
,
Gua
n
ghui Jin
,
Wei Li
,
Lihao Ge
Keywords(s):
Category(s):
Applicatio
n
,
Applicatio
n
> Research Materials
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > Eye / Ear /
N
ose / Throat
Usi
n
g Artificial Intelligence To Diagnose Uveitis
Summary: The
N
ational Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can identify retinal vasculitis using color fundus images. Description of Technology: Uveitis is caused by inflammation in the eye that can cause pain and reduce vision. The rate of uveitis in the United States is 1 in every...
Published: 8/14/2024
|
Inventor(s):
Shilpa Kodati
,
Jo
n
gwoo Kim
,
N
am Nguyen
Keywords(s):
Category(s):
Applicatio
n
> Diagnostics
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > Eye / Ear /
N
ose / Throat
Usi
n
g Artificial Intelligence To Predict The Risk Of Age-Related Macular Degeneration
Summary: The
N
ational Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can predict the probability of progression to late age-related macular degeneration. Description of Technology: In 2024, an estimated 200 million people worldwide suffer from age-related macular degeneration (AMD); projected...
Published: 8/14/2024
|
Inventor(s):
Emily Chew
,
Zhiyo
n
g Lu
,
Tiar
n
an Keenan
,
Wai Wo
n
g
,
Qi
n
gyu Chen
,
Elvira Agro
n
Keywords(s):
Category(s):
Applicatio
n
> Diagnostics
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > Eye / Ear /
N
ose / Throat
TYROSI
N
ASE Gene Therapy for Oculocutaneous Albinism type 1A
Summary: The
N
ational Eye Institute seeks research co-development partners and/or licensees for an adeno-associated viral gene therapy for Oculocutaneous Albinism type 1A. Description of Technology: Oculocutaneous albinism (OCA) is a genetically heterogeneous congenital disorder characterized by decreased or absent pigmentation in the hair,...
Published: 8/14/2024
|
Inventor(s):
Bria
n
Brooks
,
Ama
n
George
Keywords(s):
Category(s):
Applicatio
n
,
Applicatio
n
> Therapeutics
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > Eye / Ear /
N
ose / Throat
,
TherapeuticArea > Rare /
N
eglected Diseases
,
TherapeuticArea > Ophthalmology
I
n
terleukin-27 Producing B-Cell Population and Uses Thereof
Summary: The
N
ational Eye Institute (NEI) seeks research co-development partners and/or licensees to advance the production and uses of interleukin-27 (IL-27) producing B-regulatory cell (i27-Breg) therapy for immune related autoimmune disorders. These disorders include but are not limited, to age-related macular degeneration (AMD), graft-versus-host...
Published: 8/14/2024
|
Inventor(s):
Charles Egwuagu
,
Ji
n
Choi
Keywords(s):
Category(s):
Applicatio
n
> Therapeutics
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > Eye / Ear /
N
ose / Throat
,
TherapeuticArea >
N
eurology
,
TherapeuticArea > Immu
n
ology
Usi
n
g FDA-approved Small Molecule Drug Reserpine and related compounds (especially Halofantrine) To Protect Photoreceptors In Inherited Retinal Degenerations And Age-Related Macular Degeneration
Summary: The
N
ational Eye Institute seeks research co-development partners and/or licensees for a therapy using an FDA-approved small molecule drug reserpine (and related compounds especially halofantrine) that prevents photoreceptor cell death in retinal degenerations. Description of Technology: Inherited Retinal Degenerations (IRD), such as Leber...
Published: 9/18/2024
|
Inventor(s):
A
n
and Swaroop
,
Yu Holly Che
n
,
Sama
n
tha Papal
,
A
n
upam Mondal
,
Ma
n
ju Swaroop
,
Wei Zhe
n
g
,
Gregory Tawa
,
We
n
wei Huang
,
Zhiji Luo
Keywords(s):
Category(s):
Applicatio
n
> Therapeutics
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > Eye / Ear /
N
ose / Throat
Methods of Detecti
n
g Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies
Summary: The
N
ational Cancer Institute (NCI) seeks co-development partners and/or licensees for a liquid biopsy diagnostic assay capable of detecting loss of heterozygosity (LOH) and somatic mutations in genes important for antigen processing and presentation and interferon-γ response pathways. Description of Technology: Immunotherapy is...
Published: 7/26/2024
|
Inventor(s):
Scott
N
orberg
,
A
n
drew Sinkoe
,
Xiaoli
n
Wu
,
James Gulley
Keywords(s):
Category(s):
Applicatio
n
> Diagnostics
,
Collaboratio
n
Sought > Collaboration
,
TherapeuticArea > O
n
cology
,
TherapeuticArea > Immu
n
ology
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10
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