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Monoclonal Antibody for Specific Detection of the Transcription Factor Eos (Ikzf4) in Regulatory T Cells

Regulatory T cells (Tregs) are immune cells that keep the immune system balanced and prevent autoimmunity. Tregs depend on a protein called Eos (Ikzf4) that helps turn genes on and off for their development and function, but until now, antibodies used to detect and study Eos were unreliable. Researchers at the National Institute of Allergy and Infectious...

Published: 6/3/2026 | Updated: 6/3/2026 | Inventor(s): Ethan Shevach, Angela DeVico, Patricia Korty

Keywords(s):

Category(s): ResearchProducts, Application, Application > Diagnostics, Application > Therapeutics

Human antibodies with anti-lymphocyte specificities and lytic activity

Antibody therapies that target human B cells are a promising way to treat diseases like B-cell cancers and autoimmune conditions like lupus and multiple sclerosis. Traditionally, these antibodies are made in animals and modified to resemble human antibodies to reduce immune rejection. Researchers in the Laboratory of Immunoregulation (LIR) at the National...

Published: 5/21/2026 | Updated: 5/21/2026 | Inventor(s): Ainhoa Perez-Diez, Irini Sereti

Keywords(s):

Category(s): Application, ResearchProducts > Antibodies, TherapeuticArea

A Novel Strategy to Produce 6-cys Proteins Based on Pfs230D1 Domain Fusions

The Plasmodium parasite has a complex lifecycle during human infection and in the mosquito vector. Most advanced malaria vaccine candidates can confer only partial, short-term protection in malaria-endemic areas. A means of breaking the transmission of malaria to subsequent individuals could prevent a significant amount of human disease. The primary...

Published: 5/14/2026 | Updated: 5/14/2026 | Inventor(s): Patrick Duffy, Jonathan Renn

Keywords(s):

Category(s): Application, Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Sequences, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease

Neutralizing Monoclonal Antibodies Against West Nile Virus

West Nile virus (WNV) is a mosquito-borne flavivirus that can cause fever and, in some cases, severe neurologic disease. There is no approved human vaccine or specific antiviral treatment for WNV. Researchers at NIAID's Vaccine Research Center (VRC), working with collaborators at Sheba Medical Center under the PREMISE program, identified...

Published: 4/24/2026 | Updated: 4/24/2026 | Inventor(s): Daniel Douek, Chaim Schramm, Ananda Chowdhury, Parker Dabbs, Lu Wang, Leonid Serebryannyy, Theodore Pierson, Kimberly Dowd, Laura Vanblargan, Katherine Burgomaster, David Gordon, Yuxiang Wang, Yaniv Lustig, Yael Ottolenghi, Dror Harats, Sarah Smith (Kerscher)

Keywords(s):

Category(s): Application, ResearchProducts > Virus/Bacteria, ResearchProducts, ResearchProducts > Antibodies, TherapeuticArea, Application > Diagnostics

Neutralizing Antibodies Against West Nile Virus

West Nile virus (WNV) is a mosquito-borne virus that can cause severe disease affecting the brain and nervous system, especially in older adults and people with weakened immune systems. There is no approved human vaccine or specific antiviral treatment for WNV. Researchers at NIAID’s Vaccine Research Center (VRC), together with collaborators...

Published: 4/23/2026 | Updated: 4/22/2026 | Inventor(s): Theodore Pierson, Kimberly Dowd, Daniel Douek, Dror Harats, Yael Ottolenghi, Gili Regev-Yochay, Yaniv Lustig

Keywords(s):

Category(s): TherapeuticArea, Application > Vaccines, Application, Application > Diagnostics, ResearchProducts, ResearchProducts > Virus/Bacteria

Gene Editing for ALPK1 p.Thr237Met

ROSAH syndrome is a rare genetic disease caused by a mutation in the human alpha kinase 1 (ALPK1) gene (p.Thr237Met), leading to vision loss, swollen optic nerves, dry mouth, enlarged spleen, and frequent headaches. Researchers in the Laboratory of Clinical Immunology and Microbiology (LCIM) at the National Institute of Allergy and Infectious Diseases...

Published: 3/26/2026 | Updated: 3/23/2026 | Inventor(s): Christina Kozycki, Colin Sweeney, Uimook Choi

Keywords(s):

Category(s): Application, Collaboration Sought, ResearchProducts, TherapeuticArea, TherapeuticArea > Rare/Neglected Diseases

Innovative Antibody Conjugation Technology for Therapeutic and Diagnostic Applications

This pioneering technology introduces a novel method for conjugating antibodies, designed to dramatically enhance their therapeutic and diagnostic performance. By improving both binding efficiency and target specificity, this approach overcomes critical limitations of existing antibody-based therapies and imaging tools. The result is a versatile platform...

Published: 4/14/2026 | Updated: 9/22/2025 | Inventor(s): Parinaz Fathi, Frank Borris, Kaitlyn Sadtler

Keywords(s):

Category(s): Application, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease

Anti-Nucleoprotein Crimean-Congo Hemorrhagic Fever Virus Monoclonal Antibodies for Assay Creation

Crimean-Congo hemorrhagic fever (CCHF) is the most widespread form of viral hemorrhagic fever, found in Eastern and Southern Europe, the Mediterranean, northwestern China, central Asia, Africa, the Middle East, and the Indian subcontinent. Typically beginning with non-specific fever, myalgia, nausea, diarrhea, and general malaise, symptoms of infection...

Published: 7/3/2025 | Updated: 7/3/2025 | Inventor(s): Daniel Douek, David Hawman, Leonid Serebryannyy, Noemia Santana Lima, Chaim Schramm, Sarah Smith (Kerscher), Amy Henry, Alicen Spaulding

Keywords(s):

Category(s): Application, Application > Diagnostics, Collaboration Sought, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Antibodies, TherapeuticArea, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, TherapeuticArea > Rare/Neglected Diseases

EV-D68 Monoclonal Antibodies Isolated from Immunized Rhesus Macaques

Enterovirus D68 (EV-D68) has been linked to the widespread outbreaks of respiratory illness and acute flaccid myelitis (AFM) in the United States and Europe in 2014, 2016, and 2018. Although EV-D68 is now the most frequently encountered enterovirus (41.1% of cases), with an estimated global prevalence of 4%, there are no specific, FDA-approved therapeutic...

Published: 7/2/2025 | Updated: 7/2/2025 | Inventor(s): Tracy Ruckwardt, Daniel Moss, Peter Krug, Masaru Kanekiyo

Keywords(s):

Category(s): Application, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, Collaboration Sought, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts, ResearchProducts > Antibodies, TherapeuticArea, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease

Fluorinated MU-Opioid Receptor Agonists

Summary: Investigators at the National Institute on Drug Abuse seek co-development partners and/or licensees for collection of mu opioid receptor (MOR) agonists as alternatives for existing compounds. Description of Technology: Although existing opioids are excellent analgesics and useful as positron emission tomography (PET) radiotracers, they...

Published: 4/16/2026 | Updated: 12/20/2024 | Inventor(s): Michael ("Mike") Michaelides, Juan Gomez, Kenner Rice, Agnieszka Sulima, Michael Baumann

Keywords(s):

Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, TherapeuticArea > Neurology, TherapeuticArea > Radiology, Collaboration Sought > Licensing

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