Search Results - david+margulies

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Characterization of novel pan anti-HLA antibodies that block LILR inhibitory receptors and activate anti-tumor immunity

Cancer immunotherapy has transformed treatment for some patients, but many tumors still do not respond well to current options, including checkpoint inhibitors. Researchers at NIAID’s Laboratory of Immune System Biology (LISB) have developed new antibodies designed to help the immune system fight tumors. These lab-made antibodies, called pan-anti-HLA...

Published: 7/14/2026 | Updated: 7/14/2026 | Inventor(s): David Margulies, Abir Panda, Ethan Shevach, Kannan Natarajan, Patricia Korty

Keywords(s):

Category(s): Application, Application > Therapeutics, Collaboration Sought, TherapeuticArea, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease

Transgenic Mouse Models for Studying HLA-B57:01 and HLA-B15:02 Linked Immune Responses and Hypersensitivity Reactions

Transgenic mouse models expressing human HLA-B57:01 and HLA-B15:02 molecules have emerged as invaluable tools for unraveling the intricacies of immune responses and hypersensitivity reactions. The major histocompatibility complex (MHC) encoded proteins play a pivotal role in the immune system by presenting peptide fragments to T lymphocytes, and HLA-B57:01...

Published: 12/10/2024 | Updated: 12/10/2024 | Inventor(s): David Margulies, Kannan Natarajan, Mulualem Tilahun, Michael Norcross, Lisa Boyd

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Collaboration, ResearchProducts > Animal Models, ResearchProducts > Research Equipment, TherapeuticArea > Immunology