Search Results - jeffrey+schlom

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Agonist Epitopes for the Development of a Human Papillomavirus (HPV) Therapeutic Vaccine

Abstract: Human papillomavirus (HPV) has been associated with the cause of several cancer types, including cervical, anal, and head and neck cancers. There has been great success in preventing HPV infections with the development of prophylactic HPV vaccines, Gardasil and Cervarix. However, these vaccines have only been shown to prevent HPV infection...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, Kwong-Yok Tsang

Keywords(s): Agonist Epitope, CTL, Cytotoxic T Lymphocytes, HPV, Human Papillomavirus, Schlom, Therapeutic Vaccine

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

AT-3 Mouse Breast Tumor Cell Line

Abstract: Tumor cell lines are important tools for the study of cancer. However, most tumor cell lines available today do not mimic physiological tumor development, progression, and host immune responses. Autochthonous tumors include spontaneously occurring tumors and chemical, viral, or physical carcinogen-induced tumors. They are considered to model...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, Scott Abrams

Keywords(s): AT-3, Autochthonous Tumor, Autologous Tumor Cell Line, BREAST CANCER, In Vitro Animal Model, Mouse, Murine, Schlom

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials

Brachyury-directed Vaccine for the Prevention or Treatment of Cancers

Abstract: Tumor invasion and metastasis are the primary drivers of cancer-related mortality. Therapies that have an ability to specifically target invasive and/or metastatic cells are anticipated to have a significant impact in the clinical management of advanced cancers. Researchers at the NCI have developed a vaccine technology that stimulates the...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, Claudia Palena

Keywords(s): Brachyury, CANCER VACCINE, Immunotherapy, T-CELLS, Transcription factor

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Vaccines, Collaboration Sought > Licensing

Bioluminescent Bladder Cancer Cell Line for Tracking Cancer Progression

Abstract: Bladder cancer is the fifth most common cancer in the United States and one of the costliest cancers to treat. Compared to other cancer types, bladder cancer has been understudied, and there is a need for informative mouse bladder cancer models that resemble the clinical situation and allow for evaluation of chemotherapeutic or immunotherapeutic...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, John Greiner

Keywords(s): Bioluminescence, Bladder cancer, LUCIFERASE, MB49, Schlom

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

MUC-1 Tumor Antigen Agonist Epitopes for Enhancing T-cell Responses to Human Tumors

Abstract: The MUC-1 tumor associated antigen has been shown to be overexpressed and/or underglycosylated in a wide range of human cancers. The C-terminus region of MUC-1 (MUC-1C) has been shown to be an oncogene and has been associated with a more aggressive phenotype in several different cancers. Scientists at NIH have identified 7 new agonist epitopes...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, Kwong-Yok Tsang

Keywords(s): AGONIST, ANTIGEN, Epitope, MUC-1

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics