Search Results - ctl

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Agonist Epitopes for the Development of a Human Papillomavirus (HPV) Therapeutic Vaccine

Abstract: Human papillomavirus (HPV) has been associated with the cause of several cancer types, including cervical, anal, and head and neck cancers. There has been great success in preventing HPV infections with the development of prophylactic HPV vaccines, Gardasil and Cervarix. However, these vaccines have only been shown to prevent HPV infection...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, Kwong-Yok Tsang

Keywords(s): Agonist Epitope, CTL, Cytotoxic T Lymphocytes, HPV, Human Papillomavirus, Schlom, Therapeutic Vaccine

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Combination Cancer Therapy with HDAC Inhibitors

Abstract: The clinical promise of cancer immunotherapy relies on the premise that the immune system can recognize and eliminate tumor cells identified as non-self. The success of cancer immunotherapy is limited by tumor immune evasion, preventing long-lasting tumor control. Recent evidence suggests that certain anticancer therapies can alter the biology...

Published: 4/8/2024 | Inventor(s): James Hodge, Sofia Gameiro

Keywords(s): Combination Therapy, CTL, HDAC inhibition, Immunotherapy

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Enhanced Immunogenicity Against HIV-1 Using a DNA-prime Poxvirus Vaccination

Abstract: Researchers at the National Cancer Institute (NCI) have developed a method of stimulating an immune response in humans at risk for infection by, or already infected with, an Human Immunodeficiency Virus (HIV)-1 retrovirus. This method utilizes deoxyribonucleic acid (DNA) vaccines to stimulate CD8+ T cell immune responses. The DNA vaccine encodes...

Published: 8/5/2024 | Inventor(s): Genoveffa Franchini, Zdenek Hel, George Pavlakis, James Tartaglia

Keywords(s): Combination Therapy, CTL, cytotoxic T lymphocyte, Deoxyribonucleic Acid, DNA vaccine, Franchini, HIV, Human Immunodeficiency Virus, POX VIRUS

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Vaccines