Search Results - george+pavlakis

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Vaccines for HIV

Abstract: The development of an effective HIV vaccine has been an ongoing area of research. The high variability in HIV-1 virus strains has represented a major challenge in successful development. Ideally, an effective candidate vaccine would provide protection against the majority of clades of HIV. Two major hurdles to overcome are immunodominance...

Published: 5/22/2024 | Inventor(s): Barbara Felber, George Pavlakis, Antonio Valentin, James Mullins

Keywords(s): ENV, GAG, HIV Vaccine, immunogenic conserved elements

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease

Combined RNA and DNA Vaccination Strategy for Improving the Vaccine Immune Response

The development of an effective HIV vaccine has been ongoing. HIV sequence diversity and immunodominance are major obstacles in the design of an effective vaccine. Researchers at the National Cancer Institute (NCI) developed a novel vaccine strategy combining both DNA and mRNA vaccination to induce an effective immune response. This combination strategy...

Published: 5/22/2024 | Inventor(s): Barbara Felber, George Pavlakis

Keywords(s): CANCER VACCINE, DNA vaccine, ENV, Felber, GAG, HIV, Infectious Disease, Nci, Pavlakis, RNA Vaccine, SARS-CoV-2, Vaccine

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Vaccines, TherapeuticArea > Infectious Disease

Conserved Elements Vaccine for HIV

Abstract: The development of an effective HIV vaccine has been an ongoing area of research. High variability in HIV-1 virus strains, however, represents a major challenge. Ideally, an effective candidate vaccine would provide protection against the majority of clades of HIV. Two major hurdles to overcome are immunodominance and sequence diversity....

Published: 5/22/2024 | Inventor(s): George Pavlakis, Barbara Felber, James Mullins

Keywords(s): Conserved Elements, DNA vaccine, HIV, Pavlakis, Prime-boost Vaccination, Vaccine

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease

Use of Heterodimeric IL-15 in Adoptive Cell Transfer

Abstract: Adoptive cell transfer (ACT) is a promising immunotherapeutic approach for cancer treatment. During ACT, if a patient is subjected to lymphodepletion prior to cell transfer, there is an observed improvement in a patient’s response to treatment. However, lymphodepletion is associated with detrimental effects, including severe immune dysfunction...

Published: 5/22/2024 | Inventor(s): George Pavlakis, Barbara Felber, Christina Bergamaschi

Keywords(s): act, Adoptive Cell Transfer, HetIL-15, IL-15, Immunotherapy, Interleukin 15, Lymphodepletion, Receptor Alpha Complex

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Enhanced Immunogenicity Against HIV-1 Using a DNA-prime Poxvirus Vaccination

Abstract: Researchers at the National Cancer Institute (NCI) have developed a method of stimulating an immune response in humans at risk for infection by, or already infected with, an Human Immunodeficiency Virus (HIV)-1 retrovirus. This method utilizes deoxyribonucleic acid (DNA) vaccines to stimulate CD8+ T cell immune responses. The DNA vaccine encodes...

Published: 8/5/2024 | Inventor(s): Genoveffa Franchini, Zdenek Hel, George Pavlakis, James Tartaglia

Keywords(s): Combination Therapy, CTL, cytotoxic T lymphocyte, Deoxyribonucleic Acid, DNA vaccine, Franchini, HIV, Human Immunodeficiency Virus, POX VIRUS

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Vaccines