Search Results - t-cells

6 Results

Sort By:

Chimeric Antigen Receptors that Recognize Mesothelin for Cancer Immunotherapy

Abstract: Chimeric antigen receptors (CARs) with high affinity for mesothelin that can be used as an immunotherapy to treat cancers that express mesothelin, such as pancreatic cancer, ovarian cancer, and mesothelioma. The technology includes CAR constructs with one of three different mesothelin-specific antibody portions, including either the mouse-derived...

Published: 4/8/2024 | Inventor(s): Steven Feldman, Steven Rosenberg, Ira Pastan

Keywords(s): CAR, Immunotherapy, MESOTHELIN, T-CELLS

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Methods of Producing T-cell Populations Using P38 MAPK Inhibitors

Abstract: Adoptive cell therapy (ACT) uses cancer reactive T-cells to effectively treat patients. However, several obstacles inhibit the successful use of ACT for cancer treatment. Current approaches for the expansion of T-cells may produce T-cells with a terminally differentiated phenotype that is associated with diminished anti-tumor activity and...

Published: 4/8/2024 | Inventor(s): Nicholas Restifo, Shashankkumar Patel

Keywords(s): Immunotherapy. Restifo, inhibitor, Mapk, P38, T-CELLS

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Use of a Modified Adaptor Molecule LAT to Improve Immunotherapy for Cancer and Other Diseases

Abstract: One problem with the development of immunotherapy for cancer or other diseases is the inability to stimulate a sufficient immune response in patients to tumor associated antigens. The Linker Adapted for T Cell Signaling molecule (LAT) has been shown to be an important molecule in T cell signaling. The inventions described and claimed in this...

Published: 4/8/2024 | Inventor(s): Lawrence Samelson, Lakeshmi Balagopalan

Keywords(s): Immunotherapy, LAT, T-CELLS, TCR

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Brachyury-directed Vaccine for the Prevention or Treatment of Cancers

Abstract: Tumor invasion and metastasis are the primary drivers of cancer-related mortality. Therapies that have an ability to specifically target invasive and/or metastatic cells are anticipated to have a significant impact in the clinical management of advanced cancers. Researchers at the NCI have developed a vaccine technology that stimulates the...

Published: 4/8/2024 | Inventor(s): Jeffrey Schlom, Claudia Palena

Keywords(s): Brachyury, CANCER VACCINE, Immunotherapy, T-CELLS, Transcription factor

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Vaccines, Collaboration Sought > Licensing

Methods of Producing Effective T-cell Populations Using Akt Inhibitors

Published: 4/8/2024 | Inventor(s): Joseph Crompton, Nicholas Restifo

Keywords(s): act, AKT, CANCER, Immunotherapy. Adoptive Cell Therapy, Protein kinase B, Restifo, T-CELLS

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials

Cancer-reactive T cells from Peripheral Blood

Abstract: Adoptive cell therapy (ACT) using genetically engineered T-cell receptors (TCRs) is a promising cancer treatment. These TCRs target genetic mutations unique to patients and play an important role in tumor regression. However, mutation-reactive T-cells and their TCRs can be difficult to identify and isolate from patients. Therefore, we need...

Published: 4/8/2024 | Inventor(s): Alena Gros, Steven Rosenberg

Keywords(s): CANCER, Gros, Immunotherapy, mutation-reactive T-cells, Rosenberg, T-Cell Receptor, T-CELLS, TCR

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology