Search Results - shashankkumar+patel

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Methods of Producing T-cell Populations Using P38 MAPK Inhibitors

Abstract: Adoptive cell therapy (ACT) uses cancer reactive T-cells to effectively treat patients. However, several obstacles inhibit the successful use of ACT for cancer treatment. Current approaches for the expansion of T-cells may produce T-cells with a terminally differentiated phenotype that is associated with diminished anti-tumor activity and...

Published: 4/8/2024 | Inventor(s): Nicholas Restifo, Shashankkumar Patel

Keywords(s): Immunotherapy. Restifo, inhibitor, Mapk, P38, T-CELLS

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Gene-based Diagnostic Predicts Patient Response to Cancer Immunotherapy

Abstract: Immunotherapy is a promising method of treating cancer that leverages the immune system to promote tumor rejection. However, certain somatic mutations in cancer cells confer resistance to T cell-mediated cytolysis. To improve the effectiveness of immunotherapies for cancer, there exists a need to prospectively identify patients who are most...

Published: 9/13/2024 | Inventor(s): Shashankkumar Patel, Nicholas Restifo

Keywords(s): CRISPR, diagnostic, Gene, Immunotherapy, T-cell, tumor

Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing