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Use of a Modified Adaptor Molecule LAT to Improve Immunotherapy for Cancer and Other Diseases

Abstract: One problem with the development of immunotherapy for cancer or other diseases is the inability to stimulate a sufficient immune response in patients to tumor associated antigens. The Linker Adapted for T Cell Signaling molecule (LAT) has been shown to be an important molecule in T cell signaling. The inventions described and claimed in this...

Published: 4/8/2024 | Inventor(s): Lawrence Samelson, Lakeshmi Balagopalan

Keywords(s): Immunotherapy, LAT, T-CELLS, TCR

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Chimeric Adaptor Proteins (CAPs) Containing a Linker for Activation of T Cells (LAT) and a Kinase Domain for Use in T Cell-Based Immunotherapy

Abstract: T cell immunotherapy is used in the treatment of various pathologies – including cancers and infections. Current therapies employ chimeric antigen receptors (CARs) consisting of the intracellular fragment of CD3-zeta as the signaling domain with varied combinations of co-stimulatory, transmembrane, spacer/hinge, and extracellular targeting...

Published: 4/8/2024 | Inventor(s): Chang Yi, Lakeshmi Balagopalan, Katherine McIntire, Lawrence Samelson

Keywords(s): CAP, CAR, Chimeric Adaptor Protein, chimeric antigen receptor, Immunotherapy, LAT, Linker for Activation of T cells, Samelson, T cell

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics