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Chimeric Adaptor Proteins (CAPs) Containing a Linker for Activation of T Cells (LAT) and a Kinase Domain for Use in T Cell-Based Immunotherapy

Abstract: T cell immunotherapy is used in the treatment of various pathologies – including cancers and infections. Current therapies employ chimeric antigen receptors (CARs) consisting of the intracellular fragment of CD3-zeta as the signaling domain with varied combinations of co-stimulatory, transmembrane, spacer/hinge, and extracellular targeting...

Published: 4/8/2024 | Inventor(s): Chang Yi, Lakeshmi Balagopalan, Katherine McIntire, Lawrence Samelson

Keywords(s): CAP, CAR, Chimeric Adaptor Protein, chimeric antigen receptor, Immunotherapy, LAT, Linker for Activation of T cells, Samelson, T cell

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics