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Chimeric Adaptor Proteins (CAPs) Containing a Linker for Activation of T Cells (LAT) and a Kinase Domain for Use in T Cell-Based Immunotherapy

Abstract: T cell immunotherapy is used in the treatment of various pathologies – including cancers and infections. Current therapies employ chimeric antigen receptors (CARs) consisting of the intracellular fragment of CD3-zeta as the signaling domain with varied combinations of co-stimulatory, transmembrane, spacer/hinge, and extracellular targeting...

Published: 4/8/2024 | Inventor(s): Chang Yi, Lakeshmi Balagopalan, Katherine McIntire, Lawrence Samelson

Keywords(s): CAP, CAR, Chimeric Adaptor Protein, chimeric antigen receptor, Immunotherapy, LAT, Linker for Activation of T cells, Samelson, T cell

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

Fluorescent Nanodiamonds as Fiducial Markers for Microscopy

The invention relates to fluorescent nanodiamonds (FNDs) and their uses as fiducial markers for microscopy. FNDs are bright fluorescent probes that do not blink or bleach and have broad fluorescence excitation and emission peaks. The fluorescence intensity can be readily controlled by the size of the FND, the number of fluorescent centers produced...

Published: 4/8/2024 | Inventor(s): Han Wen, Jennifer Hong, Chang Yi, Ambika Bumb, Susanta Sarkar, Lawrence Samelson, Asit Manna, Keir Neuman

Keywords(s): AC2XXX, AC3XXX, AC4XXX, FIDUCIAL, Fluorescence, fluorescent, IMAGING, MICROSCOPY, Nanodiamonds, nanotechnology, PXXXXX, WIXXXX, XFXXXX, XGXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products, Application > Software / Apps, ResearchProducts > Research Equipment, Application > Medical Devices, Application > Research Materials, Application > Diagnostics