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Resolution Enhancement for Line-Scanning Excitation Microscopy

The invention describes a method for improving the spatial resolution of optical microscopes that use line-scanning excitation, such as line-scanning confocal microscopes, line-scanning STED microscopes, or line-scanning light-sheet microscopes. Common elements of the invention include: a) an apparatus for exciting and scanning a line-like excitation...

Published: 7/25/2024 | Inventor(s): Andrew York, John Giannini, Abhishek Kumar, Hari Shroff

Keywords(s): AC1XXX, AC2XXX, AC3XXX, fluorescent, MICROSCOPE, MICROSCOPY, RESOLUTION, XDXXXX, XFXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices, Application > Diagnostics

Miniature Serial Microtome for Block-Face Imaging

A microtome device is used in a variety of microcopy techniques to remove very thin (e.g., in the tens of nanometers range) portions from the top of a sample between successive images. This technology discloses a design for a microtome device that offers several unique features and advantages over commercially available microtomes. A prototype of the...

Published: 7/25/2024 | Inventor(s): Kevin Briggman

Keywords(s): AC1DXX, AC2XXX, AC3XXX, Block-face, Electron Microscopy, MICROSCOPY, MICROTOME, SCANNING, VEXXXX, VPXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Medical Devices, Application > Non-Medical Devices, TherapeuticArea > Cardiology, TherapeuticArea > Oncology, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Software / Apps, TherapeuticArea > Neurology

Hearing Safety Devices: System for Monitoring Exposure to Impulse Noise

This CDC-developed technology entails a system for monitoring and assessing the risk of auditory damage from exposure to impulse noise, such as noise created by construction machinery and firearms. Noise dosimeters have been used extensively over the past two decades to document personal exposure to noise and assure workplaces comply with permissible...

Published: 7/25/2024 | Inventor(s): Chucri Kardous

Keywords(s): AA5XXX, AAXXXX, AC1XXX, AC2XXX, ADXXXX, AE1BXX, AE1XXX, AE2BXX, AE2XXX, AE3XXX, AEXXXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Exposure, firearm, firearm safety, IMPULSE, MONITORING, NIOSH, NIOSH-DART, NOISE, Occupational health, SAFETY, Sampling, System, VPXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XIXXXX, XJXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, ResearchProducts > Computational models/software, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices

Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function

CDC researchers have developed a novel acoustic whole body plethysmograph (AWBP) that allows measurement of tidal volume in lab animals, independent of gas compression in the lung. This system provides particular advantages over the traditional whole body plethysmograph (WBP) when measuring model animals with increased gas compression due to increased...

Published: 7/25/2024 | Inventor(s): David Frazer, Jeffrey Reynolds

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC2XXX, AC3XXX, AC6XXX, Acoustic, ACXXXX, ADXXXX, AE1BXX, AE1XXX, AE3XXX, AE4XXX, AEXXXX, ANIMAL, Animal Model, ANIMAL welfare, ASTHMA, Breath, BREATHING, CDC Docket Import, CDC Docket Import CDC Prosecuting, DDXXXX, DEVICE, DEXXXX, DXXXXX, FUNCTION, IA3XXX, IA5XXX, ICXXXX, IDXXXX, LUNG, lung cancer, Lung Disease, LUNGS, Lung-Targeted, Measuring, NIOSH, NIOSH-HELD, Plethysmograph, Pulmonary, Pulmonary edema, PULMONARY FIBROSIS, research, RESEARCH TOOL, RESPIRABLE, Respiration, respiratory, Respiratory Diseases, respiratory INFECTION, Tool, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, XIXXXX, XJXXXX, YCXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, TherapeuticArea > Pulmonology, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Vaccines, Application > Therapeutics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, ResearchProducts > Computational models/software, TherapeuticArea > Oncology

Deconvolution Software for Modern Fluorescence Microscopy

This software invention pertains to Joint Richardson-Lucy (RL) deconvolution methods used to combine multiple images of an object into a single image for improving resolution in modern fluorescence microscopy. RL deconvolution merges images with very different point spread functions, such as in multi-view light-sheet microscopes, while preserving the...

Published: 7/25/2024 | Inventor(s): Maria Ingaramo, Andrew York, Hari Shroff, George Patterson

Keywords(s): AC2XXX, AC3XXX, ACXXXX, AD3XXX, ADXXXX, AXXXXX, Deconvolution, fluorescent, Image, IMAGES, IMAGING, Lucy, MICROSCOPY, Microsopy, Richardson, VPXXXX, WIXXXX, XJXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Application > Software / Apps, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology, Application > Research Materials, TherapeuticArea > Ophthalmology

Automated Microscopic Image Acquisition, Compositing and Display Software Developed for Applied Microscopy/Cytology Training and Analysis

Micro-Screen is a CDC developed software program designed to capture images and archive and display a compiled image(s) from a portion of a microscope slide in real time. This program allows for the re-creation of larger images that are constructed from individual microscopic fields captured in up to five focal planes and two magnifications. This program...

Published: 7/25/2024 | Inventor(s): Roger Taylor, James Lange, Tommy Lee, Carlyn Collins, MariBeth Gagnon

Keywords(s): AA3AXX, AA3B6X, AA3CXX, AA3XXX, AC2XXX, AC3XXX, Acquisition, ACXXXX, AD2XXX, AD3XXX, ADXXXX, Automated, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositing, DISPLAY, Image, MICROSCOPIC, OID-NCPDCID-DLS, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WBXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, XHXXXX, XJXXXX, YBXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Psychiatry/Mental Health, Application > Consumer Products, TherapeuticArea > Neurology, TherapeuticArea > Oncology, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology, TherapeuticArea > Dental, Application > Medical Devices, TherapeuticArea > Geriatrics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Non-Medical Devices, TherapeuticArea > Infectious Disease, Application > Software / Apps, Application > Research Materials, ResearchProducts > Research Equipment, Application > Diagnostics

Method for Finding Usable Portion of Sigmoid Curve (the Taylor Method), Improved Assay Readouts, and Enhanced Quality Control/Assurance

CDC researchers have developed algorithmic methods for determining sigmoid curve optimums and calculating component concentrations. Sigmoid curves are commonly generated in bioassays and used to calculate results. Various techniques have been used to define the curve, analyze the observations, and calculate a concentration. This technology is an...

Published: 7/25/2024 | Inventor(s): Thomas Taylor

Keywords(s): AA2XXX, AA5XXX, AA6XXX, AAXXXX, AB4XXX, AC2XXX, AC4XXX, AC6XXX, ACXXXX, AD3XXX, ADXXXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CURVE, Finding, OID-NCIRD-DBD, Portion, Sigmoid, USABLE, VBXXXX, VPXXXX, WAXXXX, WHXXXX, WIXXXX, WMXXXX, XHXXXX, XJXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, ResearchProducts > Computational models/software, Application > Software / Apps, Application > Diagnostics, ResearchProducts > Research Equipment, Application > Research Materials

Software to Improve the Quality of Microscopy Images

Available for licensing and commercial use is software based on an iterative deconvolution procedure that recovers images that have been blurred by a known point spread function. The software provides superior results when multiple independent observations of the same specimen are obtained. An example of such observations might be the multiple views...

Published: 4/8/2024 | Inventor(s): Andrew York, Yicong Wu, Hari Shroff

Keywords(s): AC2XXX, AC3XXX, ACXXXX, AD1XXX, ADXXXX, AXXXXX, Deconvolution, image quality, IMAGING, MICROSCOPY, RESOLUTION, Signal-to-Noise, software

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Java Applet for Modeling Human Metabolism and Energy Expenditure for Adaptive Dieting and Exercise Regimens

Known methods for predicting weight loss fail to account for slowing of metabolism as weight is lost and therefore overestimate the degree of weight loss. While this limitation of the 3500 Calorie per pound rule has been known for some time, it was not clear how to dynamically account for the metabolic slowing. The invention provides a Java applet for...

Published: 7/25/2024 | Inventor(s): Dhruva Chandramohan, Carson Chou, Kevin Hall

Keywords(s): AC2XXX, ACXXXX, AD1XXX, Adaptions, Adn, Adult, ADXXXX, AXXXXX, Body, CHANGES, Dieting, During, Energy, EXERCISE, Expenditure, Fat, Human, ID2XXX, IDXXXX, IXXXXX, Mathematical, Metabolism, Model, PREDICTS, Simulates, That, Weight

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

AFMAnalyze: Software Automation and Analysis of Atomic Force Microscopy (AFM) Data

AFMAnalyze is a software package that is designed to significantly enhance the analysis and application of Atomic Force Microscopy (AFM) data. This software automates AFM data collection and analysis, and is equipped with a Graphical User Interface (GUI)-intensive computational tool that is capable of replacing the manual or algorithmic methods for...

Published: 7/25/2024 | Inventor(s): Brett Shoelson

Keywords(s): AC2XXX, ACXXXX, AD3XXX, ADXXXX, AFM, AFMAnalyze:, analysis, ATOMIC, Automating, AXXXXX, DATA, FORCE, MICROSCOPY, PACKAGE, software

Category(s): Collaboration Sought > Licensing

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