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Multiplexing Homocysteine in Primary Newborn Screening Assays Using Maleimides as Select Derivatization Agents
Homocystinuria (HCU), a group of inherited disorders, causes symptoms ranging from failure to thrive and developmental delays in infants or young children to abnormal blood clots with onset in adults.1 Approximately 1 in 200,000 to 335,000 people have HCU globally.2 Various clinical settings use the dried blood spot (DBS) for sample collection methods...
Published: 7/25/2024   |   Inventor(s): Charles Pickens, Konstantinos Petritis
Keywords(s): 4AXXXX, Agents, ASSAYS, Derivatization, Hcy, HOMOCYSTEINE, Maleimides, Multiplexing, Newborn, Primary, screening, SELECTIVE, VDXXXX, VPXXXX, WFXXXX, WHXXXX, WIXXXX, XCXXXX, XHXXXX, YAXXXX, YDXXXX, YFXXXX
Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Dental, Application > Research Materials, ResearchProducts > Research Equipment, Application > Occupational Safety and Health, Application > Diagnostics
High-Throughput COVID-19 Diagnostic Test that Detects Both Viral and Host Nucleic Acid
The rapid worldwide spread and impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a need for accurate, reliable, and readily accessible testing on a massive scale. NIEHS researchers developed a massively paralleled multiplexed screening method using next generation sequencing (NGS). This method uses...
Published: 7/25/2024   |   Inventor(s): Brian Papa, Oswaldo Lozoya
Keywords(s): Acid, assay, DA4BXX, Diagnosis, HOST, Infection, Massively, Multi-patient, Nucleic, Paralleled, PATHOGENIC, PHYSIOLOGY, sequencing, Surveillance, VLXXXX, WBXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Diagnostics
A Novel Reagent for Labeling PET Tracers at Trifluoromethyl Groups
The molecular imaging technique of positron emission tomography (PET) is an increasingly important tool in biomedical research and in drug discovery and development. Many small molecule drugs and potential PET radiotracers carry trifluoromethyl (CF3) groups. Because CF3 groups are generally considered to be metabolically stable, there is a strong interest...
Published: 7/25/2024   |   Inventor(s): Mohammad Haskali, Victor Pike
Keywords(s): :, [11C]Fluoroalkanes, Added, AGENT, LABELING, Method, No-Carrier, PET, Producing, Radiotracers, VAXXXX, VCXXXX, VDXXXX, VEXXXX, VNXXXX, WBXXXX, WIXXXX, XDXXXX, XFXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Geriatrics, Application > Software / Apps, TherapeuticArea > Psychiatry/Mental Health, TherapeuticArea > Neurology, Application > Medical Devices, TherapeuticArea > Immunology
Near Real-time, Low-cost, Hand-held Sensors for Measuring Elemental Concentration of Airborne Particles for Indoor or Outdoor Air Quality Monitoring
Airborne particles can have great impact on air quality, weather, and human health. In particular, long-term inhalation of toxic particulate matter in workplaces could pose a significant health risk. NIOSH scientists have developed a new, low-cost approach based on application of atmospheric radio frequency glow discharge (rf-GD) optical emission spectroscopy...
Published: 7/25/2024   |   Inventor(s): Lina Zheng, Pramod Kulkarni
Keywords(s): AEROSOLS, analysis, Atmospheric, DART, Discharge, Elemental, Emission, Glow, NIOSH-DART, SPECTROSCOPY, VBXXXX, VPXXXX, WAXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, XGXXXX, XIXXXX, YAXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Cardiology, Application > Occupational Safety and Health, Application > Vaccines, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Consumer Products
Heartland Virus Humanized Monoclonal Antibodies for Diagnostic and Therapeutic Development
Heartland virus (HRTV) is a novel tick-borne virus first discovered in 2009 that causes flu-like symptoms such as fever, headaches, fatigue, muscle aches, and diarrhea. Patients with HRTV often have low white blood cell counts, low platelet counts, and abnormal liver function tests which can become severe. Cases of Heartland virus disease have been...
Published: 7/25/2024   |   Inventor(s): Aaron Brault, Amanda Calvert
Keywords(s): antibodies, Diagnostics, heartland, Listed LPM Houze as of 4/15/2015, monoclonal, NCEZID, NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Specific, therapeutics, virus, WBXXXX, WFXXXX, WJXXXX, XAXXXX, YAXXXX, YBXXXX, YCXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, ResearchProducts > Antibodies, Application > Occupational Safety and Health, Application > Therapeutics, Application > Consumer Products, Application > Diagnostics
Rapid Colorimetric Detection of Zika Virus from Serum and Urine Specimens by RT-LAMP (Reverse Transcription Loop-Mediated Isothermal Amplification).
The Zika virus (ZIKV) can be passed from a pregnant woman to her fetus. Resulting infection by this virus can cause early miscarriage and a pattern of severe birth defects in fetuses and infants. Therefore, a rapid diagnostic assay that can be performed throughout pregnancy in a clinical setting is vital for prenatal care of women living in areas where...
Published: 7/25/2024   |   Inventor(s): Amanda Calvert
Keywords(s): amplification, COLORIMETRIC, Detection, Isothermal, Loop-, Mediated, NCEZID-DVBD, RAPID, Reverse, RT-LAMP, RT-LAMP., SERUM, SPECIMENS, transcription, Urine, virus, VLXXXX, WBXXXX, WFXXXX, WHXXXX, WIXXXX, XEXXXX, YBXXXX, YDXXXX, YFXXXX, Zika
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Diagnostics, Application > Therapeutics, Application > Research Materials, Application > Occupational Safety and Health
Swing-Away Winch Cathead Guard
Shrimp boat operators use two trawl retrieval mechanisms mounted on the same winch frame. The main spools are used in the first operation; the shrimpers stand within inches of rotating cathead drums and guide incoming wire rope onto the main spools. Second, lazy lines are wrapped multiple times around each of the two spinning catheads (horizontal beams...
Published: 7/25/2024   |   Inventor(s): Chelsea Woodward
Keywords(s): Cathead, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, Guard, Listed LPM Surabian as of 4/15/2015, Maritime, NIOSH, Occupational health, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Swing-Away, VPXXXX, WGXXXX, WINCH, WIXXXX, WORKER, WORKER safety, XDXXXX, XIXXXX, YAXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Medical Devices, Application > Occupational Safety and Health, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Oncology, TherapeuticArea > Ophthalmology
Emergency Maritime Battery Charger
Boats and other watercrafts have emergency lifesaving equipment like strobe lamps to help rescuers locate individuals overboard in the event of a disaster. The battery life of the equipment is limited, so the amount of time rescuers have to find the victims is also limited. An emergency battery charger that can power emergency equipment is needed to...
Published: 7/25/2024   |   Inventor(s): Chelsea Woodward
Keywords(s): Battery, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, Charger/maintainer, EMERGENCY, FISH, Listed LPM Surabian as of 4/15/2015, Maritime, NIOSH, Occupational health, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SAFE, SAFETY, VPXXXX, WGXXXX, WIXXXX, WORK, WORKER safety, XDXXXX, XIXXXX, YAXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, Application > Occupational Safety and Health, TherapeuticArea > Ophthalmology, Application > Non-Medical Devices, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, Application > Medical Devices
Monoclonal Antibodies to the HIV-1 Core Protein p24
The core proteins of HIV-1 are secreted into the environment during replication in the human body. The detection of the core protein p24 (molecular mass of 24 kilodaltons) serves as an indicator of early HIV-1 infection, and assays detecting it have been available since the late 1980s. However, the development of a rapid assay for the detection of HIV-1...
Published: 7/25/2024   |   Inventor(s): Chou-Pong Pau, Shon Nguyen, Susan Wells, Sherry Owen, Jason Goldstein, Dennis Bagarozzi, Timothy Granade
Keywords(s): antibodies, Core, DA4XXX, DDXXXX, HIV-1, Listed LPM Houze as of 4/15/2015, monoclonal, NCHHSTP-DHAP, P24, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, VLXXXX, WBXXXX, WIXXXX, XAXXXX, XHXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Antibodies, Application > Diagnostics, Application > Research Materials, ResearchProducts > Research Equipment
Adaptor for Suspending a Cryovial Over a Centrifuge Tube
The invention pertains to a device and system for expediting the thawing of frozen specimens (e.g., cryopreserved cells) contained in cryo-vials. An adaptor support suspends cryo-vials over a centrifuge tube containing culture medium in an inverted position. The adaptor has an elongated tubular body. While relatively basic, the adaptor dramatically...
Published: 4/8/2024   |   Inventor(s): Margaret Beddall, Pratip Chattopadhyay, Mario Roederer
Keywords(s): AC3XXX, AC4XXX, AC6XXX, ADAPTER, AFXXXX, Cells, Cryopreservation, Cryopreserved, Cryo-sample, FROZEN, Listed LPM Shmilovich as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Thawing, WIXXXX, WMXXXX, XDXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Consumer Products, Application > Non-Medical Devices, Application > Medical Devices, Application > Research Materials
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