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Micropatterning of Extracellular Matrix Proteins Using Microphoto-ablation Of Poly vinyl Alcohol (PVA) Monolayers

Available for licensure and commercial development is a micro-photoablation (µPA) method used as a micro-patterning technique to attach ECM proteins or other biological molecules to specified locations. Advantages of this photolytic technique are that it: (a) is stampless, (b) allows for flexible pattern generation to the submicron level, (c) allows...

Published: 7/25/2024 | Inventor(s): Kenneth Yamada, Andrew Doyle

Keywords(s): AA2XXX, AA3AXX, AA3XXX, AAXXXX, AC3XXX, ACXXXX, AXXXXX, CELL-BINDING, Cellular Interactions, Extracellular, INTERACTION, INTERACTIONS, Micropatterning, Microphoto-ablation, Polyvinyl, PVA

Category(s): Application > Research Materials, ResearchProducts > Research Equipment

Resolution Enhancement for Light Sheet Microscopy Systems

The invention pertains to a technique for enhancing the resolution of images in light sheet microscopy by adding additional enhanced depth-of-focus optical arrangements and high numerical aperture objective lenses. The technique employs an arrangement of three objective lenses and a processor for combining captured images. The image composition utilizes...

Published: 7/25/2024 | Inventor(s): Yicong Wu, Sara Abrahamsson, Hari Shroff

Keywords(s): AA2XXX, AC1XXX, AC3XXX, ADXXXX, Light-emitting, Light-scattering, MICROSCOPY, VPXXXX, WIXXXX, XFXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Medical Devices, Application > Research Materials, Application > Software / Apps, TherapeuticArea > Cardiology, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices

Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function

CDC researchers have developed a novel acoustic whole body plethysmograph (AWBP) that allows measurement of tidal volume in lab animals, independent of gas compression in the lung. This system provides particular advantages over the traditional whole body plethysmograph (WBP) when measuring model animals with increased gas compression due to increased...

Published: 7/25/2024 | Inventor(s): David Frazer, Jeffrey Reynolds

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC2XXX, AC3XXX, AC6XXX, Acoustic, ACXXXX, ADXXXX, AE1BXX, AE1XXX, AE3XXX, AE4XXX, AEXXXX, ANIMAL, Animal Model, ANIMAL welfare, ASTHMA, Breath, BREATHING, CDC Docket Import, CDC Docket Import CDC Prosecuting, DDXXXX, DEVICE, DEXXXX, DXXXXX, FUNCTION, IA3XXX, IA5XXX, ICXXXX, IDXXXX, LUNG, lung cancer, Lung Disease, LUNGS, Lung-Targeted, Measuring, NIOSH, NIOSH-HELD, Plethysmograph, Pulmonary, Pulmonary edema, PULMONARY FIBROSIS, research, RESEARCH TOOL, RESPIRABLE, Respiration, respiratory, Respiratory Diseases, respiratory INFECTION, Tool, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, XIXXXX, XJXXXX, YCXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, TherapeuticArea > Pulmonology, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Vaccines, Application > Therapeutics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, ResearchProducts > Computational models/software, TherapeuticArea > Oncology

Focused Electrostatic Collection of Aerosol Particles for Chemical Analysis by Spectroscopic Techniques

This CDC-developed technology is an aerosol preconcentration unit (APU) designed for use with spectroscopic detection techniques, including emission, Raman, or infrared spectroscopies. Most existing pulsed microplasma techniques, such as laser-induced breakdown, for aerosols rely mainly on filter-based collection and suffer from poor accuracy, precision,...

Published: 7/25/2024 | Inventor(s): Prasson Diwakar, Pramod Kulkarni

Keywords(s): AA2XXX, AA3AXX, AA3B5X, AA3CXX, AA3XXX, AC1XXX, AC3XXX, AC4XXX, AC6XXX, ACXXXX, ADXXXX, AE2AXX, AE2XXX, AE3XXX, AE4XXX, AEROSOL, AEXXXX, AG1XXX, ANALYSER, ANALYSES, analysis, apparatus, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DAXXXX, DEVICE, DXXXXX, IA5XXX, IDXXXX, Method, NIOSH, NIOSH-DART, OID-NCIRD-DVD, optical, PLASMA, SPECTROSCOPY, TECHNIQUE, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WEXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, XGXXXX, XHXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Research Materials, Application > Occupational Safety and Health, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, TherapeuticArea > Ophthalmology, Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Pulmonology, Application > Non-Medical Devices, TherapeuticArea > Infectious Disease, Application > Software / Apps, TherapeuticArea > Cardiology

Cylindrical Handle Dynamometer for Improved Grip-Strength Measurement

CDC researchers have developed an improved dynamometer device and method for measuring maximum hand grip force or grip-strength. Human test subjects were used in conducting experiments to evaluate the handle and to assess the measurement method. In contrast to the currently used "Jamar handle" grip strength dynamometer devices, the cylindrical handle...

Published: 7/25/2024 | Inventor(s): Daniel Welcome, Christopher Warren, Thomas McDowell, Renguang Dong, Bryan Wimer

Keywords(s): AA1XXX, AA2XXX, AA4BXX, AA4XXX, AAXXXX, AB1XXX, AFXXXX, ASSESSMENT, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Configuration, Dynamometer, GRIP, HAND, Improved, NIOSH-HELD, Strength, VAXXXX, VEXXXX, VPXXXX, WBXXXX, WGXXXX, XDXXXX, XIXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices, TherapeuticArea > Cardiology, TherapeuticArea > Neurology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Geriatrics, Application > Medical Devices

Photoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification

CDC scientists have developed a rapid and cost-efficient method for generating fluorescently labeled primers for PCR and real-time PCR. At present, fluorescent primers are useful for detecting and identifying microbes and specific nucleic acid sequences, amplifying nucleic acids for pyro-sequencing, determining the levels of gene expression, and many...

Published: 7/25/2024 | Inventor(s): Vincent Hill, Brian Holloway, Jothikumar Narayanan

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC4XXX, AC5XXX, AC6XXX, Acid, ACXXXX, AE1BXX, AG1XXX, amplification, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, ELECTRON, Nucleic, OID-NCEZID-DFWED, PET, PHOTOINDUCED, PRIMER, TRANSFER, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WHXXXX, WIXXXX, WMXXXX, XBXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, Application > Diagnostics, Application > Occupational Safety and Health, Application > Research Materials, TherapeuticArea > Oncology, ResearchProducts > Computational models/software, TherapeuticArea > Neurology, TherapeuticArea > Cardiology, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Psychiatry/Mental Health, TherapeuticArea > Immunology, Application > Software / Apps, Application > Vaccines, TherapeuticArea > Infectious Disease, TherapeuticArea > Geriatrics

Device to Measure Muscle Contractile-Relaxant and Epithelial Bioelectric Responses of Perfused, Intact Tracheal Airways Tissue In Vitro

CDC and collaborative researchers have developed a device allowing for simultaneous measurement of smooth muscle contractile/relaxant activity and transepithelial potential difference (Vt) [or short circuit currents (Isc)] and resistance (Rt) within an intact airway in vitro. Investigation of the underlying mechanisms of lung diseases, such as asthma...

Published: 7/25/2024 | Inventor(s): Yi Jing, Michael Van Scott, Jeffrey Fedan

Keywords(s): AA2XXX, AAXXXX, AC4XXX, AC5XXX, ACXXXX, apparatus, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CHARACTERISTICS, ICXXXX, IDXXXX, INTACT, IXXXXX, Measuring, Method, PHYSIOLOGICAL, Trachea, Vitro, VPXXXX, WBXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, YAXXXX, YBXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Medical Devices, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, Application > Research Materials, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Dental, Application > Diagnostics, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, Application > Non-Medical Devices

A Simple Colorimetric Assay for Anti-malarial Drugs Quality Assurance and Rapid, On-site Counterfeit Detection

This CDC assay aims to lessen the anti-malarial drug counterfeiting epidemic by testing for the artemisinin-type drugs (the active compound), through the use of a simple, inexpensive colorimetric test. Poor quality and counterfeit drugs pose an immediate threat to public health and undermine malaria control efforts, resulting in resistant-parasites...

Published: 7/25/2024 | Inventor(s): Michael Green

Keywords(s): AA2XXX, AA5XXX, AA6XXX, AAXXXX, AB2XXX, AB4XXX, AC5XXX, AE2BXX, AE2CXX, AE2XXX, AE3XXX, AEXXXX, AG2XXX, AG3XXX, AGXXXX, ANTIMALARIAL, Artemesin, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, COLORIMETRIC, Derivatives, test, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WDXXXX, WFXXXX, WHXXXX, WMXXXX, XCXXXX, XDXXXX, XFXXXX, XIXXXX, YBXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Endocrinology, Application > Occupational Safety and Health, Application > Diagnostics, TherapeuticArea > Dental, TherapeuticArea > Oncology, Application > Consumer Products, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, Application > Medical Devices, Application > Software / Apps

Use of Detector Response Curves to Optimize Settings for Mass Spectrometry

This CDC developed optimization technology allows one to characterize the behavior of the coefficient of variation (CV) for a range of mass spectrometer machine settings. Surface-enhanced laser desorption/ionization (SELDI) and matrix-assisted laser desorption/ionization (MALDI) are used for the early detection of numerous diseases, for example cervical...

Published: 7/25/2024 | Inventor(s): Brian Gurbaxani, Vincent Emanuele

Keywords(s): AA2XXX, AC3XXX, ADXXXX, ASSISTED, CDC Docket Import, CDC Docket Import CDC Prosecuting, CURVES, DESORPTION/IONIZATION, DETECTOR, Laser, Mass, MATRIX, OID-NCEZID-DHCPP, Optimize, RESPONSE, SETTINGS, SPECTROSCOPY, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WHXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, XHXXXX, XJXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, ResearchProducts > Computational models/software, Application > Software / Apps, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Therapeutics, TherapeuticArea > Neurology, Application > Vaccines, Application > Medical Devices, TherapeuticArea > Geriatrics, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Consumer Products, Application > Diagnostics, ResearchProducts > Research Equipment, Application > Research Materials, Application > Occupational Safety and Health

Non-radioactive, Miniature Bipolar Aerosol Particle Charger for Personal, Portable Instrumentation

This CDC developed invention is a novel device for a miniature, nonradioactive bipolar charger to electrically charge aerosol particles for use in personal and portable aerosol instrumentation. Such devices are an integral component of aerosol instruments employing electrical mobility-based techniques. Current, commercial state-of-the-art mobility...

Published: 7/25/2024 | Inventor(s): Chaolong Qi, Pramod Kulkarni

Keywords(s): AA2XXX, AA4BXX, AAXXXX, AE1XXX, AE2BXX, AE2XXX, AE3XXX, AEROSOL, AEXXXX, AFXXXX, AGXXXX, AXXXXX, BIPOLAR, CDC Docket Import, CDC Docket Import CDC Prosecuting, Charger, NIOSH-DART, NON-RADIOACTIVE, PARTICLES, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XIXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Ophthalmology, Application > Diagnostics, Application > Vaccines, Application > Occupational Safety and Health, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology, Application > Medical Devices, Application > Non-Medical Devices, TherapeuticArea > Cardiology

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