Search Results - antimalarial

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A Simple Colorimetric Assay for Anti-malarial Drugs Quality Assurance and Rapid, On-site Counterfeit Detection

This CDC assay aims to lessen the anti-malarial drug counterfeiting epidemic by testing for the artemisinin-type drugs (the active compound), through the use of a simple, inexpensive colorimetric test. Poor quality and counterfeit drugs pose an immediate threat to public health and undermine malaria control efforts, resulting in resistant-parasites...

Published: 7/25/2024 | Inventor(s): Michael Green

Keywords(s): AA2XXX, AA5XXX, AA6XXX, AAXXXX, AB2XXX, AB4XXX, AC5XXX, AE2BXX, AE2CXX, AE2XXX, AE3XXX, AEXXXX, AG2XXX, AG3XXX, AGXXXX, ANTIMALARIAL, Artemesin, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, COLORIMETRIC, Derivatives, test, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WDXXXX, WFXXXX, WHXXXX, WMXXXX, XCXXXX, XDXXXX, XFXXXX, XIXXXX, YBXXXX, YEXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Endocrinology, Application > Occupational Safety and Health, Application > Diagnostics, TherapeuticArea > Dental, TherapeuticArea > Oncology, Application > Consumer Products, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, Application > Medical Devices, Application > Software / Apps

Antimalarial Inhibitors that Target the Plasmodial Surface Anion Channel (PSAC) Protein and Development of the PSAC Protein as Vaccine Targets

There are two related technologies, the first being small molecule inhibitors of the malarial plasmodial surface anion channel (PSAC) and the second being the PSAC protein itself as a vaccine candidate. The PSAC protein is produced by the malaria parasite within host erythrocytes and is crucial for mediating nutrient uptake. In vitro data show that...

Published: 7/25/2024 | Inventor(s): Sanjay Desai

Keywords(s): Anion, ANTIMALARIAL, CHANNEL, DC2XXX, DCXXXX, DXXXXX, Plasmodial, Surface, TARGET, THERAPY

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease

Compounds That Treat Malaria and Prevent Malaria Transmission

Malaria is the single leading cause of death, especially among children, in the developing world. Malaria is caused by infection with parasites of the genus Plasmodium, transmitted by mosquitos. In addition to transmission, vital steps in the parasite lifecycle occur in the mosquito host. The invention offered for licensing relates to therapeutic compounds...

Published: 7/25/2024 | Inventor(s): Jing Yuan, Sittiporn Pattaradilokrat, Ruili Huang, Ronald Johnson, Dipak Raj, Xin-zhuan Su

Keywords(s): ANTIMALARIAL, DB2XXX, DBXXXX, Discovery, DRUGS, DXXXXX, Malaria (Plasmodium sp.), Potential, UBXXXX, UXXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases

A Novel Treatment for Malarial Infections

The inventions described herein are antimalarial small molecule inhibitors of the plasmodial surface anion channel (PSAC), an essential nutrient acquisition ion channel expressed on human erythrocytes infected with malaria parasites. These inhibitors were discovered by high-throughput screening of chemical libraries and analysis of their ability to...

Published: 7/25/2024 | Inventor(s): Sanjay Desai

Keywords(s): Anion, ANTAGONISTS, ANTIMALARIAL, BBXXXX, BCXXXX, CHANNEL, DB2XXX, DBXXXX, Development, DRUG, DXXXXX, LEAD, Malaria, Malaria (Plasmodium sp.), MOLECULES, Plasmodial, Surface

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease