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Antimalarial Inhibitors that Target the Plasmodial Surface Anion Channel (PSAC) Protein and Development of the PSAC Protein as Vaccine Targets

There are two related technologies, the first being small molecule inhibitors of the malarial plasmodial surface anion channel (PSAC) and the second being the PSAC protein itself as a vaccine candidate. The PSAC protein is produced by the malaria parasite within host erythrocytes and is crucial for mediating nutrient uptake. In vitro data show that...

Published: 7/25/2024 | Inventor(s): Sanjay Desai

Keywords(s): Anion, ANTIMALARIAL, CHANNEL, DC2XXX, DCXXXX, DXXXXX, Plasmodial, Surface, TARGET, THERAPY

Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease

TRPC Knockout (KO) Mice and Mice with a Floxed Allele of TRPC Ion Channel Genes

TRPCs (Canonical Transient Receptor Potential Channels) are a group of non-selective cation channels that allow sodium and calcium into cells. There are seven different genes in mice that code TRPCs. The in vivo roles played by TRPCs as a whole are poorly understood and very little is known about the in vivo roles played by individual TRPCs nor the...

Published: 7/25/2024 | Inventor(s): Joel Abramowitz, Lutz Birnbaumer

Keywords(s): ALLELE, CHANNEL, Floxed, Gene, ION, Knockout, Listed LPM Tong as of 4/15/2015, Mice, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, TRPC3, TRPC5, TRPC7, WBXXXX, WIXXXX, WJXXXX, WKXXXX, XEXXXX, YAXXXX

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Single Channel MRI Guidewire

The invention offered for licensing and commercial development is in the field of Interventional Magnetic Resonance Imaging (“iMRI”). More specifically the invention discloses a guidewire for magnetic resonance imaging with a single channel design to reduce complexity and to provide conspicuous tip visibility under MRI. In the design of the present...

Published: 7/25/2024 | Inventor(s): Ozgur Kocaturk, Christina Saikus, Merdim Sonmez

Keywords(s): AA3BXX, AA3XXX, AAXXXX, Active, AXXXXX, CHANNEL, Conspicuous, Design, Guidewire, MRI, SHAFT, Single, Tip, Visibility

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

A Novel Treatment for Malarial Infections

The inventions described herein are antimalarial small molecule inhibitors of the plasmodial surface anion channel (PSAC), an essential nutrient acquisition ion channel expressed on human erythrocytes infected with malaria parasites. These inhibitors were discovered by high-throughput screening of chemical libraries and analysis of their ability to...

Published: 7/25/2024 | Inventor(s): Sanjay Desai

Keywords(s): Anion, ANTAGONISTS, ANTIMALARIAL, BBXXXX, BCXXXX, CHANNEL, DB2XXX, DBXXXX, Development, DRUG, DXXXXX, LEAD, Malaria, Malaria (Plasmodium sp.), MOLECULES, Plasmodial, Surface

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease