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TRPC Knockout (KO) Mice and Mice with a Floxed Allele of TRPC Ion Channel Genes
Case ID:
TAB-2990
Web Published:
12/6/2022
Description:
TRPCs (Canonical Transient Receptor Potential Channels) are a group of non-selective cation channels that allow sodium and calcium into cells. There are seven different genes in mice that code TRPCs. The in vivo roles played by TRPCs as a whole are poorly understood and very little is known about the in vivo roles played by individual TRPCs nor the role of these channels in specific tissues or cells.
In this invention, mice with a floxed allele of TRPC3, TRPC5, or TRPC7 were generated. Knockout mice of TRPC3, TRPC5, or TRPC7 can be used to study the function of the respective genes. The knockout mice can then be used to identify TRPC3/TRPC5/TRPC7-dependent processes. When mice with a floxed allele of one of the TRPCs are crossed with mice expressing Cre recombinase, mice can be generated in which TRPC3 has been deleted. This can be done in a tissue specific manner.
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Direct Link:
https://nih.technologypublisher.com/tech/TRPC_Knockout_(KO)_Mice_and_Mice_wit h_a_Floxed_Allele_of_TRPC_Ion_Channel_Genes
Category(s):
Licensing
Therapeutics
Research Materials
Diagnostics
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For Information, Contact:
Vidita Choudhry
Technology Development Specialist
NIH Technology Transfer
301-594-4095
vidita.choudhry@nih.gov
Inventors:
Joel Abramowitz
Lutz Birnbaumer
Keywords:
ALLELE
CHANNEL
Floxed
Gene
ION
Knockout
Listed LPM Tong as of 4/15/2015
Mice
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
TRPC3
TRPC5
TRPC7
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