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Floxed Targeted Mouse Strain for Use in Conditional Deletion of the Irf8 Gene

IRF8, a member of interferon regulatory factor (IRF) family of transcription factors is a novel intrinsic transcriptional inhibitor of TH17-cell differentiation. TH17-cells are believed to be involved in the pathogenesis of various autoimmune/inflammatory diseases. These materials could be used to help define patterns of gene expression important for...

Published: 7/25/2024 | Inventor(s): Herbert Morse

Keywords(s): Approved, Conditional, Deletion, Design, Development, Gene, Generate, IRF8, Knockout, Listed LPM Vepa as of 4/15/2015, Mouse, Need, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECOGNIZED, RXXXXX, Strain, Used

Category(s): Collaboration Sought > Collaboration, Application > Research Materials

A3 Adenosine Receptor Agonists to Treat Chemotherapy-induced Peripheral Neuropathy

This invention claims species-independent agonists of A3AR, specifically (N)-methanocarba adenine nucleosides and related pharmaceutical compositions. The A3 adenosine receptor (A3AR) subtype has been linked with helping protect the heart from ischemia, controlling inflammation, and regulating cell proliferation. Agonists of the human A3AR subtype...

Published: 4/8/2024 | Inventor(s): Dilip Tosh, Kenneth Jacobson

Keywords(s): 2-Arylethynyl, A3, ADENOSINE, CB3CXX, CB3XXX, CBXXXX, CXXXXX, Design, N-Methanocarba, Nucleosides, Receptor-Selective, Structure-based

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics

Single Channel MRI Guidewire

The invention offered for licensing and commercial development is in the field of Interventional Magnetic Resonance Imaging (“iMRI”). More specifically the invention discloses a guidewire for magnetic resonance imaging with a single channel design to reduce complexity and to provide conspicuous tip visibility under MRI. In the design of the present...

Published: 7/25/2024 | Inventor(s): Ozgur Kocaturk, Christina Saikus, Merdim Sonmez

Keywords(s): AA3BXX, AA3XXX, AAXXXX, Active, AXXXXX, CHANNEL, Conspicuous, Design, Guidewire, MRI, SHAFT, Single, Tip, Visibility

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Species-Independent A3 Adenosine Receptor Agonists Which May Be Useful for Treating Ischemia, Controlling Inflammation, and Regulating Cell Proliferation

This invention claims species-independent agonists of A3AR, specifically (N)-methanocarba adenine nucleosides and pharmaceutical compositions comprising such nucleosides. The A3 adenosine receptor (A3AR) subtype has been linked with helping protect the heart from ischemia, controlling inflammation, and regulating cell proliferation. Agonists of the...

Published: 7/25/2024 | Inventor(s): Artem Melman, Kenneth Jacobson

Keywords(s): 5'Uronamides, A3, ADENOSINE, AGONISTS, Design, IA3XXX, IAXXXX, IB1XXX, IBXXXX, IXXXXX, N-Methanocarba, OB1XXX, OBXXXX, OXXXXX, Receptor-Selective, Species-Independent

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials