Search Results - structure-based

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Recombinant Stabilized Prefusion Protein of Respiratory Syncytial Virus for Use as a Subunit Vaccine

The invention, a stabilized recombinant prefusion F protein (pre F), is a candidate subunit vaccine for Respiratory Syncytial Virus (RSV). Pre-F is stabilized in the prefusion conformation and displays epitopes not present in postfusion F protein. Several potent RSV neutralizing antibodies bind pre F, but not postfusion F. Therefore, immunization...

Published: 7/25/2024 | Inventor(s): Jason Gorman, Gilad Ofek, Marie Pancera, Mallika Sastry, Sanjay Srivatsan, Yongping Yang, Lei Chen, Cinque Soto, Tongqing Zhou, Barney Graham, Peter Kwong, Masaru Kanekiyo, Michael Joyce, Baoshan Zhang, Guillaume Stewart-Jones, Jeffrey Boyington, Man Chen, Gwo-Yu Chuang, Ivelin Georgiev, Jason McLellan

Keywords(s): CONFORMATION, DC5BXX, DC5XXX, DCXXXX, DXXXXX, F, GLYCOPROTEIN, Listed LPM Thalhammer-Reyero as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Prefusion, PrefusionConformation, RSV, Stabilization, Structure-based, Vaccine, VLXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease

A3 Adenosine Receptor Agonists to Treat Chemotherapy-induced Peripheral Neuropathy

This invention claims species-independent agonists of A3AR, specifically (N)-methanocarba adenine nucleosides and related pharmaceutical compositions. The A3 adenosine receptor (A3AR) subtype has been linked with helping protect the heart from ischemia, controlling inflammation, and regulating cell proliferation. Agonists of the human A3AR subtype...

Published: 4/8/2024 | Inventor(s): Dilip Tosh, Kenneth Jacobson

Keywords(s): 2-Arylethynyl, A3, ADENOSINE, CB3CXX, CB3XXX, CBXXXX, CXXXXX, Design, N-Methanocarba, Nucleosides, Receptor-Selective, Structure-based

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics

Triazole Derivatives of 4,7-disubstituted 2 naphthoic acid (PPTN) as P2Y14 Receptor Antagonists

The Molecular Recognition Section of NIDDK announces the availability of a novel triazole-based probes, structures which act as antagonists at human P2Y14 receptors. Although the physiologic functions of this receptor remain undefined, recently it has been strongly implicated in immune and inflammatory responses. Prior work with a 4,7-disubstituted...

Published: 7/25/2024 | Inventor(s): Evgeny Kiselev, Elisa Uliassi, Anna Junker, Kenneth Jacobson

Keywords(s): Alkyne, ANTAGONISTS, IB3XXX, IB4XXX, ID1XXX, P2Y14, Patent Category - Chemistry, Probe, RECEPTOR, small molecule, Structure-based, Triazole, VFXXXX, WIXXXX, WKXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Endocrinology, ResearchProducts > Research Equipment, TherapeuticArea > Immunology, TherapeuticArea > Pulmonology, Application > Research Materials