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Stapled Peptides for Treatment of Cardiovascular Diseases and Inflammation

The invention is directed to small molecule mimetics of apolipoproteins that have an inter-helical hydrocarbon bond, which stabilizes helix formation. Apolipoproteins facilitate the transport of lipids and cholesterol in the body. Mimetics of apolipoproteins have been used to treat cholesterol-related disorders. However, these mimetics are susceptible...

Published: 4/8/2024 | Inventor(s): Marcelo Amar, Imoh Ikpot, Denis Sviridov, David Osei-Hwedieh, Alan Remaley

Keywords(s): Acylation, ALKYLATION, AMPHIPATHIC, Biological, IB1CXX, IB1DXX, IB1EXX, IB1FXX, IB1XXX, IBXXXX, IXXXXX, Peptides, PROPERTIES, Their, therapeutic

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Research Materials

SIRT2 Inhibitors as Novel Therapeutics for Myocardial Infarction and Ischemic Stroke and to Prevent Necrosis

Sirtuin 2 (SIRT2) inhibitors to reduce necrosis and, thereby, as novel therapeutics to treat ischemic stroke and myocardial infarction. Accumulating evidence indicates that programmed necrosis plays a critical role in cell death during ischemia-reperfusion. NIH investigators have shown that the NAD-dependent deacetylase SIRT2 binds constitutively...

Published: 4/8/2024 | Inventor(s): Toren Finkel, Nisha Narayan

Keywords(s): Against, AGK2, deacetylase, IB1FXX, IB1XXX, IBXXXX, inhibitor, IXXXXX, NAD-dependent, NB1HXX, NB1XXX, NBXXXX, NECROSIS, NXXXXX, PROTECTS, Sirt2

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Neurology

Small Molecule MRS5474 with Anticonvulsant Activity for Treatment of Epilepsy

Adenosine modulates many physiological processes by activating specific adenosine receptors. These adenosine receptors play a critical role in the regulation of cellular signaling and are broadly distributed throughout the body. Thus, the ability to modulate adenosine receptor-mediated signaling is an attractive therapeutic strategy for a broad range...

Published: 7/25/2024 | Inventor(s): Dilip Tosh, Kenneth Jacobson

Keywords(s): A3, Activity, ADENOSINE, AGONISTS, Agonists:, Al, ANTAGONISTS, Anticonvulsant, Derivatives, Docking, IB1FXX, IB1XXX, IBXXXX, IXXXXX, NB1EXX, NB1HXX, NB1XXX, NBXXXX, N-Methanocarba, Nucleosides, NXXXXX, PARTIAL, Patent Category - Chemistry, POTENT, RECEPTOR, TRUNCATED

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Neurology, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics

Novel Small Molecule Agonists of the Relaxin Receptor as Potential Therapy for Heart Failure and Fibrosis

The present invention is directed to novel small molecule agonists of the mammalian relaxin family receptor 1 (RXFP1), including human RXFP1. Activation of RXFP1 induces: 1) vasodilation due to up-regulation of the endothelin system; 2) extracellular matrix remodeling; 3) moderation of inflammation by reducing levels of inflammatory cytokines; and...

Published: 7/25/2024 | Inventor(s): Wei Zheng, Marc Ferrer-Alegre, Catherine Chen, Alexander Agoulnik, Noel Southall, Jingbo Xiao, Juan Marugan

Keywords(s): 1, IB1XXX, IB3XXX, IB5XXX, IB6XXX, IBXXXX, IXXXXX, MODULATORS, POTENT, RECEPTOR, Relaxin, RXFP1, SELECTIVE

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Cardiology, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics

Therapeutic Peptide Treatment for Dyslipidemic and Vascular Disorders

This invention is directed to use of certain peptide analogs comprising multiple amphipathic helical domains that are able to promote cellular lipid efflux and stimulate lipoprotein lipase activity. As a result, administration of invention peptides lead to reduced incidences of hypertriglyceridemia without inducing toxicity. Existing peptides that stimulate...

Published: 7/25/2024 | Inventor(s): Marcelo Amar, Alan Remaley

Keywords(s): 3-@hydroxyacyl-coa dehydrogenase deficiency, ApoA-I, HAD deficiency, HIS deficiency, Histidinemia, Hypertriglyceridemia, IB1XXX, IBXXXX, IXXXXX, Mimetic, Patent Category - Biotechnology, Peptides, VDXXXX, VHXXXX, WBXXXX, WJXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, Application > Diagnostics, Application > Research Materials

Species-Independent A3 Adenosine Receptor Agonists Which May Be Useful for Treating Ischemia, Controlling Inflammation, and Regulating Cell Proliferation

This invention claims species-independent agonists of A3AR, specifically (N)-methanocarba adenine nucleosides and pharmaceutical compositions comprising such nucleosides. The A3 adenosine receptor (A3AR) subtype has been linked with helping protect the heart from ischemia, controlling inflammation, and regulating cell proliferation. Agonists of the...

Published: 7/25/2024 | Inventor(s): Artem Melman, Kenneth Jacobson

Keywords(s): 5'Uronamides, A3, ADENOSINE, AGONISTS, Design, IA3XXX, IAXXXX, IB1XXX, IBXXXX, IXXXXX, N-Methanocarba, OB1XXX, OBXXXX, OXXXXX, Receptor-Selective, Species-Independent

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials

Novel Roles of a DNA Repair Protein, DNA-PKcs, in Obesity, Neurological Function, and Aging

The catalytic subunit of the DNA-dependent protein kinase complex (DNA-PKcs) has been shown to be important in DNA repair and VDJ recombination in lymphocytes. The inventors have discovered that DNA-PKcs also plays novel, important roles in energy regulation and neurological function. The inventors observed that mature DNA-PKcs-deficient mice (also...

Published: 7/25/2024 | Inventor(s): Jay Chung

Keywords(s): Aging, ANXIETY, Cardiovascular, depression, DIABETES, DNA-Dependent, DNA-PKcs, Endurance, Energy, HEART, IB1XXX, IB3XXX, IB6XXX, IBXXXX, Inflammation, insulin, INSULIN-DEPENDENT, IXXXXX, LEARNING, MEMORY, METABOLIC, Metabolism, Mitochondria, Neurological, OBESITY, REGULATION, TYPE-2, Weight

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology

Collagen-Induced Platelet Aggregation Inhibitor from Mosquito Salivary Glands

Exposed collagen in injured blood vessels provides a substrate for platelets to adhere and aggregate initiating the first step in thrombosis, the formation of blood clots inside a blood vessel. Despite the essential role of platelets in vascular injury, excessive platelet aggregation may also result in thrombotic diseases such as stroke and heart attack. Available...

Published: 7/25/2024 | Inventor(s): Eric Calvo

Keywords(s): AGGREGATION, Collagen-platelet, GLANDS, IB1EXX, IB1XXX, IB3XXX, IBXXXX, inhibitor, IXXXXX, Malaria, Mosquito, Salivary

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Therapeutics

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