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Stapled Peptides for Treatment of Cardiovascular Diseases and Inflammation
The invention is directed to small molecule mimetics of apolipoproteins that have an inter-helical hydrocarbon bond, which stabilizes helix formation. Apolipoproteins facilitate the transport of lipids and cholesterol in the body. Mimetics of apolipoproteins have been used to treat cholesterol-related disorders. However, these mimetics are susceptible...
Published: 4/8/2024
|
Inventor(s):
Marcelo Amar
,
Imoh Ikpot
,
Denis Sviridov
,
David Osei-Hwedieh
,
Alan Remaley
Keywords(s):
Acylation
,
ALKYLATION
,
AMPHIPATHIC
,
Biological
,
IB1CXX
,
IB1DXX
,
IB1EXX
,
IB1FXX
,
IB1XXX
,
IBXXXX
,
IXXXXX
,
Peptides
,
PROPERTIES
,
Their
,
therapeutic
Category(s):
Collaboration Sought > Collaboration
,
Application > Therapeutics
,
Application > Diagnostics
,
TherapeuticArea > Cardiology
,
Application > Research Materials
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