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Stapled Peptides for Treatment of Cardiovascular Diseases and Inflammation

The invention is directed to small molecule mimetics of apolipoproteins that have an inter-helical hydrocarbon bond, which stabilizes helix formation. Apolipoproteins facilitate the transport of lipids and cholesterol in the body. Mimetics of apolipoproteins have been used to treat cholesterol-related disorders. However, these mimetics are susceptible...

Published: 4/8/2024 | Inventor(s): Marcelo Amar, Imoh Ikpot, Denis Sviridov, David Osei-Hwedieh, Alan Remaley

Keywords(s): Acylation, ALKYLATION, AMPHIPATHIC, Biological, IB1CXX, IB1DXX, IB1EXX, IB1FXX, IB1XXX, IBXXXX, IXXXXX, Peptides, PROPERTIES, Their, therapeutic

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Research Materials