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SIRT2 Inhibitors as Novel Therapeutics for Myocardial Infarction and Ischemic Stroke and to Prevent Necrosis
Case ID:
TAB-2515
Web Published:
12/6/2022
Description:
Sirtuin 2 (SIRT2) inhibitors to reduce necrosis and, thereby, as novel therapeutics to treat ischemic stroke and myocardial infarction. Accumulating evidence indicates that programmed necrosis plays a critical role in cell death during ischemia-reperfusion. NIH investigators have shown that the NAD-dependent deacetylase SIRT2 binds constitutively to receptor-interacting protein 3 (RIP3) and that deletion or knockdown of SIRT2 prevents formation of the RIP1-RIP3 complex in mice. These investigators also found that genetic or pharmacological inhibition of SIRT2 blocks cellular necrosis induced by TNF-alpha and RIP1 is a critical target of SIRT2-dependent deacetylation. Further studies also showed that the hearts of
Sirt2
–/–
mice, or wild-type mice treated with a specific pharmacological inhibitor of SIRT2, show marked protection from ischemic injury. These results implicate SIRT2 as an important regulator of programmed necrosis and indicate that SIRT2 inhibitors may constitute a novel approach to protect against necrotic injuries, including ischemic stroke and myocardial infarction.
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Direct Link:
https://nih.technologypublisher.com/tech/SIRT2_Inhibitors_as_Novel_Therapeuti cs_for_Myocardial_Infarction_and_Ischemic_Stroke_and_to_Prevent_Necrosis
Category(s):
Collaboration
Diagnostics
Research Materials
Therapeutics
Cardiology
Neurology
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For Information, Contact:
Inteum Admin
NIH Technology Transfer
Inventors:
Toren Finkel
Nisha Narayan
Keywords:
Against
AGK2
deacetylase
IB1FXX
IB1XXX
IBXXXX
inhibitor
IXXXXX
NAD-dependent
NB1HXX
NB1XXX
NBXXXX
NECROSIS
NXXXXX
PROTECTS
Sirt2
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