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N-Methanocarba Adenosine Derivatives and Their Dendrimer Conjugates as A3 Receptor Agonists

This technology relates to specific (N)-methanocarba adenine nucleosides that have been developed and dendrimers that connect these compounds to create molecules with multiple targets. Dendrimers are essentially repeated molecular branches presenting the core receptor-binding molecules. The compounds synthesized function as agonists and antagonists...

Published: 7/25/2024 | Inventor(s): Dilip Tosh, Kenneth Jacobson

Keywords(s): A3, ADENOSINE, AGONISTS, CONJUGATES, DENDRIMER, Derivatives, IAXXXX, IBXXXX, IXXXXX, N-Methanocarba, OBXXXX, OXXXXX, Patent Category - Chemistry, RECEPTOR, Their

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Species-Independent A3 Adenosine Receptor Agonists Which May Be Useful for Treating Ischemia, Controlling Inflammation, and Regulating Cell Proliferation

This invention claims species-independent agonists of A3AR, specifically (N)-methanocarba adenine nucleosides and pharmaceutical compositions comprising such nucleosides. The A3 adenosine receptor (A3AR) subtype has been linked with helping protect the heart from ischemia, controlling inflammation, and regulating cell proliferation. Agonists of the...

Published: 7/25/2024 | Inventor(s): Artem Melman, Kenneth Jacobson

Keywords(s): 5'Uronamides, A3, ADENOSINE, AGONISTS, Design, IA3XXX, IAXXXX, IB1XXX, IBXXXX, IXXXXX, N-Methanocarba, OB1XXX, OBXXXX, OXXXXX, Receptor-Selective, Species-Independent

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials