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Longer-lived Mouse Models for Studying Gaucher Disease

The invention is a novel longer-lived mouse model for Gaucher disease. Gaucher disease is a genetic disorder that results from deficiencies in the enzyme glucocerebrosidase (GBA). The use of animal models to study how the disease progresses has been invaluable in research of this disorder. However, existing mouse models have been limited due to early...

Published: 7/25/2024 | Inventor(s): Mary Lamarca, Edward Ginns

Keywords(s): ANIMAL, DISORDERS, Gaucher, Gaucher Disease, Human, IDXXXX, Inherited, Models, RXXXXX, TRANSGENIC, VHXXXX, VPXXXX, WIXXXX, WJXXXX, WKXXXX, WMXXXX, XEXXXX

Category(s): Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology

Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function

CDC researchers have developed a novel acoustic whole body plethysmograph (AWBP) that allows measurement of tidal volume in lab animals, independent of gas compression in the lung. This system provides particular advantages over the traditional whole body plethysmograph (WBP) when measuring model animals with increased gas compression due to increased...

Published: 7/25/2024 | Inventor(s): David Frazer, Jeffrey Reynolds

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC2XXX, AC3XXX, AC6XXX, Acoustic, ACXXXX, ADXXXX, AE1BXX, AE1XXX, AE3XXX, AE4XXX, AEXXXX, ANIMAL, Animal Model, ANIMAL welfare, ASTHMA, Breath, BREATHING, CDC Docket Import, CDC Docket Import CDC Prosecuting, DDXXXX, DEVICE, DEXXXX, DXXXXX, FUNCTION, IA3XXX, IA5XXX, ICXXXX, IDXXXX, LUNG, lung cancer, Lung Disease, LUNGS, Lung-Targeted, Measuring, NIOSH, NIOSH-HELD, Plethysmograph, Pulmonary, Pulmonary edema, PULMONARY FIBROSIS, research, RESEARCH TOOL, RESPIRABLE, Respiration, respiratory, Respiratory Diseases, respiratory INFECTION, Tool, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, XIXXXX, XJXXXX, YCXXXX, YEXXXX, YFXXXX

Category(s): Collaboration Sought > Licensing, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, TherapeuticArea > Pulmonology, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Vaccines, Application > Therapeutics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, ResearchProducts > Computational models/software, TherapeuticArea > Oncology

Prevention and Treatment of Multiple Sclerosis (MS) by Administering E-Selectin

The invention is a method and composition for inhibiting or treating symptoms of inflammatory demyelination or inflammation associated with autoimmune disorders. This is accomplished by administering recombinant E-selectin protein intranasally and resulting in E selectin-specific regulatory T-cells. These regulatory T-cells suppress activation of blood...

Published: 4/8/2024 | Inventor(s): Jacqueline Shukaliak-Quandt

Keywords(s): ANIMAL, Autoimmune, BBXXXX, BCXXXX, brain, Damage, EAE, Encephalomylelitis, e-selectin, EXPERIMENTAL, IMMUNOLOGICAL, Model, Multiple sclerosis, NB1HXX, NB1JXX, NB1XXX, NBXXXX, NXXXXX, PREVENTS, Tolerization

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Neurology

CC Chemokine Receptor 5 DNA, New Animal Models and Therapeutic Agents for HIV Infection

Chemokine receptors are expressed by many cells, including lymphoid cells, and function to mediate cell trafficking and localization. CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor (GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes, macrophages, and immature dendritic cells....

Published: 7/25/2024 | Inventor(s): Christopher Broder, Philip Murphy, Ghalib Alkhatib, Edward Berger, Yu Feng, Paul Kennedy, Christophe Combadiere

Keywords(s): 5, Agents, AIDS, also designated as CKR5, ANIMAL, antiretroviral, ANTIVIRAL, cc, CC-CKR5 chemokine receptor, CCR5 and CMKBR5, Chemokine, DB4AXX, DB4XXX, DBXXXX, DDXXXX, DNA, DXXXXX, HIV, Hyper IgM syndrome, Immunodeficiency 2, Immunodeficiency 4, Immunodeficiency-3, Infection, MIP-1a & MIP-1b, Models, Patent Category - Biotechnology, Patent Category - Contested Proceedings, RECEPTOR, receptor for RANTES, Severe combined immunodeficiency, x-linked, therapeutic, Wiskott Aldrich syndrome

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics

Rabbit Antisera to Various Matrix, Matricellular, and Other Secreted Proteins

The extracellular matrix (ECM) is composed of a group of proteins that regulate many cellular functions, such as cell shape, adhesion, migration, proliferation, and differentiation. Deregulation of ECM protein production or function contributes to many pathological conditions, including asthma, chronic obstructive pulmonary disease, arthrosclerosis,...

Published: 7/25/2024 | Inventor(s): Larry Fisher

Keywords(s): ANIMAL, Antisera, Human, Listed LPM Maddox as of 4/15/2015, Matricellular, MATRIX, polyclonal, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, proteins, rabbit, RXXXXX, SECRETED, VARIOUS, VAXXXX, VCXXXX, VDXXXX, VGXXXX, VIXXXX, WIXXXX, XAXXXX, XCXXXX, YAXXXX

Category(s): TherapeuticArea > Endocrinology, TherapeuticArea > Cardiology, TherapeuticArea > Oncology, ResearchProducts > Antibodies, Application > Research Materials, TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, Application > Diagnostics