Search Results - edward+berger

2 Results

Sort By:

4G10, a Monoclonal Antibody Against the Chemokine Receptor CXCR4, Raised Against a Synthetic Peptide of 38 Residues in Length Derived from the N-terminal Sequence of CXCR4

This invention identifies a monoclonal antibody (4G10) against the chemokine receptor CXCR4 and is a mouse IgG1 antibody. CXCR4 has been identified as a co-receptor mediating entry of HIV-1 into T cells. Subsequently, CXCR4 has been implicated in normal physiological functions, including activation of B cells and B cell progenitors and guiding their...

Published: 7/25/2024 | Inventor(s): Edward Berger, Christopher Broder

Keywords(s): CC2XXX, CCXXXX, CXXXXX, DDXXXX, DXXXXX, IDXXXX, IXXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology

CC Chemokine Receptor 5 DNA, New Animal Models and Therapeutic Agents for HIV Infection

Chemokine receptors are expressed by many cells, including lymphoid cells, and function to mediate cell trafficking and localization. CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor (GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes, macrophages, and immature dendritic cells....

Published: 7/25/2024 | Inventor(s): Christopher Broder, Philip Murphy, Ghalib Alkhatib, Edward Berger, Yu Feng, Paul Kennedy, Christophe Combadiere

Keywords(s): 5, Agents, AIDS, also designated as CKR5, ANIMAL, antiretroviral, ANTIVIRAL, cc, CC-CKR5 chemokine receptor, CCR5 and CMKBR5, Chemokine, DB4AXX, DB4XXX, DBXXXX, DDXXXX, DNA, DXXXXX, HIV, Hyper IgM syndrome, Immunodeficiency 2, Immunodeficiency 4, Immunodeficiency-3, Infection, MIP-1a & MIP-1b, Models, Patent Category - Biotechnology, Patent Category - Contested Proceedings, RECEPTOR, receptor for RANTES, Severe combined immunodeficiency, x-linked, therapeutic, Wiskott Aldrich syndrome

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics