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Monoclonal Antibodies Targeting Human DNA Polymerase beta, a DNA Repair Enzyme

Available for licensing are monoclonal antibodies targeting human DNA polymerase beta (Pol B). Pol B is a constitutively expressed "housekeeping" enzyme that plays a role in base excision repair (BER), a cellular defense mechanism that repairs DNA base damage and loss. Aberrant Pol B expression is associated with genomic instability indicating that...

Published: 7/25/2024 | Inventor(s): Rajendra Prasad, Samuel Wilson

Keywords(s): AC5XXX, ACXXXX, ANTIBODY, AXXXXX, CC2XXX, CCXXXX, CDXXXX, CXXXXX, DNA, DNA polymerase, DNA polymerase beta, monoclonal, Monoclonal Antibody, monoclonal antibody based assays, polymerase

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

Mouse Monoclonal Antibodies to MAD1, a Human Spindle Assembly Checkpoint Protein for Maintaining Chromosomal Segregation

Scientists at the National Institutes of Health have developed mouse monoclonal antibodies against the human spindle assembly checkpoint protein, MAD1. The spindle assembly checkpoint in mitotic cell division regulates the fidelity of chromosome segregation during cell division. MAD1 is an important component of this checkpoint control, which if compromised,...

Published: 7/25/2024 | Inventor(s): Kuan-teh Jeang (Estate)

Keywords(s): (4)r syndrome, Against, ANEUPLOIDY, antibodies, ASSEMBLY, C syndrome, CAXXXX, CC2XXX, CCXXXX, CHECKPOINT, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, CXXXXX, G syndrome, Human, Hypertelorism with esophageal abnormality and hypospadias, MAD1, monoclonal, Mouse, N syndrome, Protein, R(6) syndrome, R(7) syndrome, spindle, Syndrome X, W syndrome, W syndrome; Syndrome W

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials

A New Mouse Monoclonal Antibody Against Human Microphthalmia Transcription Factor (MITF)

Micropthalmia Transcription Factor (MITF) plays an important role in melanocyte development and melanoma growth. MITF is important for embryonic development, regulating the generation of pigment cells and formation of melanomas and other tumors. MITF is made in various isoforms that may play unique roles for different organs during different developmental...

Published: 4/8/2024 | Inventor(s): Wen Fang Liu, Hideki Murakami, Heinz Arnheitter

Keywords(s): ANTIBODY, CANCER, CC2XXX, CCXXXX, CXXXXX, factor, Human, Microphthalmia, MITF, monoclonal, Mouse, RELATED, transcription

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Oncology, Application > Research Materials

Monoclonal Antibody to the Protein NCOA6 (also called ASC-2, AIB-3)

The invention relates to monoclonal antibodies that bind to the transcription factor NCOA6 (ASC-2, AIB-3, TRB, TRAP250, NRC). The antibodies have proven successful reagents for Western blotting and for purifying complexes containing NCOA6. The Western blot experiments revealed that NCOA6 is over-expressed in several breast cancer cell lines, and the...

Published: 7/25/2024 | Inventor(s): Paul Meltzer

Keywords(s): CC2XXX, CCXXXX, CXXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Research Materials

4G10, a Monoclonal Antibody Against the Chemokine Receptor CXCR4, Raised Against a Synthetic Peptide of 38 Residues in Length Derived from the N-terminal Sequence of CXCR4

This invention identifies a monoclonal antibody (4G10) against the chemokine receptor CXCR4 and is a mouse IgG1 antibody. CXCR4 has been identified as a co-receptor mediating entry of HIV-1 into T cells. Subsequently, CXCR4 has been implicated in normal physiological functions, including activation of B cells and B cell progenitors and guiding their...

Published: 7/25/2024 | Inventor(s): Edward Berger, Christopher Broder

Keywords(s): CC2XXX, CCXXXX, CXXXXX, DDXXXX, DXXXXX, IDXXXX, IXXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology

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