Search Results - samuel+wilson

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Pyrophosphate Analog HIV-1 Reverse Transcriptase Inhibitors

The invention relates to compounds that inhibit HIV-1 DNA synthesis mediated by reverse transcriptase (RT). HIV-1 DNA synthesis by RT utilizes deoxynucleoside 5’-triphosphate (dNTP) as substrate and like many other enzymes, the reaction is reversible. Pyrophosphate analogs like imidodiphosphate strongly promote reverse reaction dNTP products containing...

Published: 7/25/2024 | Inventor(s): William (Bill) Beard, David Shock, Samuel Wilson

Keywords(s): DB4AXX, HIV-1, INHIBITING, PYROPHOSPHATE, TRANSCRIPTASE, VLXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease

Monoclonal Antibodies Targeting Human DNA Polymerase beta, a DNA Repair Enzyme

Available for licensing are monoclonal antibodies targeting human DNA polymerase beta (Pol B). Pol B is a constitutively expressed "housekeeping" enzyme that plays a role in base excision repair (BER), a cellular defense mechanism that repairs DNA base damage and loss. Aberrant Pol B expression is associated with genomic instability indicating that...

Published: 7/25/2024 | Inventor(s): Rajendra Prasad, Samuel Wilson

Keywords(s): AC5XXX, ACXXXX, ANTIBODY, AXXXXX, CC2XXX, CCXXXX, CDXXXX, CXXXXX, DNA, DNA polymerase, DNA polymerase beta, monoclonal, Monoclonal Antibody, monoclonal antibody based assays, polymerase

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology

High Level Expression and Purification of Untagged and Histidine-tagged Human Immunodeficiency Virus Type-1 Reverse Transcriptase

Human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT) gene encodes 560 amino acids. In the virus, however, HIV-1 RT occurs as a dimer of two related polypeptides, p66 and p51 subunits at a molar ratio of 1:1. The p51 subunit is derived from a C-terminal proteolytic cleavage of the p66 subunit. This invention describes a simplified protocol...

Published: 7/25/2024 | Inventor(s): Rajendra Prasad, Ester Hou, Samuel Wilson

Keywords(s): BBXXXX, DDXXXX, DEXXXX, DXXXXX, Expression, High, Histidine-tagged, Human, Hyper IgM syndrome, Immunodeficiency, Immunodeficiency 2, Immunodeficiency 4, Immunodeficiency-3, Level, purification, Reverse, Severe combined immunodeficiency, x-linked, TRANSCRIPTASE, TYPE-1, Untagged, virus, Wiskott Aldrich syndrome

Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Infectious Disease